Laboratory criteria for antiphospholipid syndrome: communication from the SSC of the ISTH
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Restricting the choice of assays reduces interlaboratory and interassay variability and the number of false positives.
“a restriction in the choice of assays reduces the interlaboratory and interassay variability, as well as the number of false positives.2”
From Guidance from the Scientific and Standardization Committee for lupus anticoagulant/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis (2020) · cites this paper as [2]
The ‘Anticardiolipin and beta2-glycoprotein I antibodies’ section (page unavailable) says harmonized protocols on automated platforms may reduce interlaboratory variation. The ‘Antibody profiles’ section (page unavailable) also notes interassay variability, but the paper does not say that restricting assay choice reduces either form of variability or the number of false positives. (LLM, conf=0.84)
Experimental — accuracy not yet measuredCut-off values in our study were calculated by the 99th percentile on 120 healthy donors.
“Cut-off values in our study were calculated by the 99th percentile on 120 healthy donors 5”
From Clinical Relevance of Isolated Lupus Anticoagulant Positivity in Patients with Thrombotic Antiphospholipid Syndrome (2021) · cites this paper as [5]
The paper’s recommended laboratory testing table specifies a threshold above the 99th percentile of normal controls, and its section on anticardiolipin and β2-glycoprotein I antibodies discusses a cut-off calculated from the 99th percentile. It does not specify 120 healthy donors or verify the citing authors’ study-specific calculation. (LLM, conf=0.87)
Experimental — accuracy not yet measuredLupus anticoagulant is one of three laboratory criteria used to identify antiphospholipid syndrome.
“Lupus anticoagulant (LA) is one of the three laboratory criteria for the identification of the antiphospholipid syndrome (APS).1,2”
Retesting positive after 12 weeks strengthens the initial result and adds confidence, particularly amid poor standardization and interfering factors.
“A confirmatory positive test after 12 weeks renders the initial test result more reliable and increases assurance of a test result in the context of poor standardization and interferences affecting the test result.2,3”
Variability between LA and solid-phase assay reagents from different manufacturers can contribute to different aPL profiles depending on the locally employed battery of aPL assays.
“Similarly, variability between LA and solid-phase assay reagents from different manufacturers can contribute to different aPL profiles depending on the locally employed battery of aPL assays [2].”
From Triple-positive antiphospholipid syndrome does not guarantee positivity in each lupus anticoagulant assay (2023) · cites this paper as [2]
LAC-positive patients were tested positive on two separate occasions according to ISTH guidelines.
“The LAC-positive patients were tested positive on two separate occasions according to the ISTH guidelines. 5”
From Clinical Relevance of Isolated Lupus Anticoagulant Positivity in Patients with Thrombotic Antiphospholipid Syndrome (2021) · cites this paper as [5]
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Research works printed but not linked: 1
- Devreese K, Kelchtermans H, de Laat B. Differences in sensitiv- ity of two automated panels for anticardiolipin and anti- beta2glycoprotein I antibodies in the laboratory diagnosis of antiphospholipid syndrome due to the exposure of the domain I epitope of beta2glycoprotein I on the solid phase. J Thromb Hae- most 2014; 12: 55.
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“LA is one of the three laboratory criteria (Sydney criteria) defining antiphospholipid syndrome (APS) [5], a systemic autoimmune disease defined by thrombotic or obstet-rical events that occur in patients with persistent antiphospholipid antibodies [6].”
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Self-citation
- Authors
- Devreese, K. M. J., Ortel, T. L., Pengo, V., & de Laat, B.
- Affiliations
- Ghent University Hospital (BE)
- Duke Medical Center (US)
- University of Padua (IT)
- Corresponding author
- Devreese, K.M.J.
- Venue
- Journal of Thrombosis and Haemostasis
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 16
- Issue
- 4
- Pages
- 809-813
- ISSN
- 1538-7836 (ISSN-L)
- OpenAlex
- W2791992225
- Cited by
- 269
- References
- 48
- Citations by year
- 2026: 20 · 2025: 25 · 2024: 27 · 2023: 42 · 2022: 41 · 2021: 43 · 2020: 37 · 2019: 26 · 2018: 8
- FWCI
- 24.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Thrombosis and Haemostasis (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- antiphospholipid syndrome, classification criteria, lupus anticoagulant, anticardiolipin antibodies, anti-beta2-glycoprotein I antibodies, thrombosis, pregnancy morbidity, laboratory confirmation
- MeSH terms
- Hematologic Tests, Humans, Predictive Value of Tests, Reproducibility of Results, Biomarkers, Lupus Coagulation Inhibitor, Antiphospholipid Syndrome, Antibodies, Antiphospholipid, Antibodies, Anticardiolipin, Consensus, beta 2-Glycoprotein I
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