Characterization of fetal arrhythmias by means of fetal magnetocardiography in three cases of difficult ultrasonographic imaging
Open accessAbstract
Characterization of ultrasound detected fetal arrhythmias is generally performed by means of M‐mode and pulsed Doppler echocardiography (fECHO), sonographic techniques that allow only indirect and approximate reconstruction of the true electrophysiological events that occur in the fetal heart. Several studies demonstrated the ability of fetal magnetocardiography (fMCG) to identify fetal arrhythmias. We report on three women, studied after the 32 nd gestational week, who were referred for fMCG because of unsatisfying fetal cardiac visualization with fECHO due to maternal obesity, fetus in constant dorsal position hiding the fetal heart, intrauterine growth retardation, and oligohydramnios. Minor pericardial effusion was present in the third patient and digoxin therapy was given. FMCG were recorded with a 77‐channel MCG system working in a shielded room. Independent Component Analysis (FastICA algorithm) was used to reconstruct fetal signals. The good quality of the retrieved fetal signals allowed real‐time detection of arrhythmias and their classification as supraventricular extrasystoles (SVE), with/without aberrant ventricular conduction and/or atrioventricular block. The time course of the fetal cardiac rhythm was reconstructed for the entire recording duration; hence, fetal heart rate variability could be studied in time and frequency. Since isolated extrasystoles may progress to more hazardous supraventricular tachycardias, the noninvasive antenatal characterization of, even transient, fetal arrhythmias and their monitoring during pregnancy can be of great clinical impact.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Parallel research efforts with shielded and unshielded MCG over the last three decades have provided evidence of well-defined fields of clinical application, such as emergency triage of chest pain, diagnosis of ischemic and non-ischemic cardiomyopathies, heart transplant rejection, non-invasive 3D EAI of arrhythmogenic substrates and mechanisms, fetal MCG, and prenatal diagnosis of arrhythmogenicリ
“provided evidence of well-defined fields of clinical application, such as the emergency triage of patients with chest pain, the diagnosis of different kinds of ischemic and non-ischemic cardiomyopathies, the heart transplant rejection (80, 81), the non-invasive 3D EAI of arrhythmogenic substrates and mechanisms (82), fetal MCG, and in particular the prenatal diagnosis of arrhythmogenic risk and”
From Clinical magnetocardiography: the unshielded bet—past, present, and future (2023) · cites this paper as [54]
Split into 2 atoms — 1 confirmed, 1 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289 · see citing works
An Information-Maximization Approach to Blind Separation and Blind Deconvolution
Bell, A. J., & Sejnowski, T. J. (1995) · Neural Computation · doi:10.1162/neco.1995.7.6.1129 · Cited by 8,986 · see citing works
Independent component analysis, A new concept?
Comon, P. (1994) · Signal Processing · doi:10.1016/0165-1684(94)90029-9 · Cited by 8,150 · see citing works
Fast and robust fixed-point algorithms for independent component analysis
Hyvärinen, A. (1999) · IEEE Transactions on Neural Networks · doi:10.1109/72.761722 · Cited by 6,239 · see citing works
A Fast Fixed-Point Algorithm for Independent Component Analysis
Hyvärinen, A., & Erkki Oja, A. (1997) · Neural Computation · doi:10.1162/neco.1997.9.7.1483 · Cited by 3,373 · see citing works
Handbook for Digital Signal Processing
Sengupta, S. K. (1994) · Technometrics · doi:10.1080/00401706.1994.10485863 · Cited by 414 · see citing works
Kleinman, C. S., Donnerstein, R. L., Jaffe, C. C., DeVore, G. R., Weinstein, E. M., Lynch, D. C., Talner, N. S., Berkowitz, R. L., & Hobbins, J. C. (1983) · The American Journal of Cardiology · doi:10.1016/s0002-9149(83)80042-3 · Cited by 200 · see citing works
Monitoring the fetal heart non-invasively: a review of methods
Peters, M. J., Crowe, J. A., Piéri, J.-F., Quartero, H. W. P., Hayes‐Gill, B., James, D. K., Stinstra, J. G., & Shakespeare, S. A. (2001) · Journal of Perinatal Medicine · doi:10.1515/jpm.2001.057 · Cited by 190 · see citing works
Fetal heart rate variability and complexity in the course of pregnancy
Leeuwen, P. V., Lange, S., Bettermann, H., Grönemeyer, D. H. W., & Hatzmann, W. (1999) · Early Human Development · doi:10.1016/s0378-3782(98)00102-9 · Cited by 153 · see citing works
Non-invasive fetal electrocardiography in singleton and multiple pregnancies
Taylor, M. J. O., Smith, M. J., Thomas, M., Green, A. R., Cheng, F., Oseku‐Afful, S., Wee, L., Fisk, N. M., & Gardiner, H. M. (2003) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1046/j.1471-0528.2003.02005.x · Cited by 146 · see citing works
Wakai, R. T., Strasburger, J. F., Li, Z., Deal, B. J., & Gotteiner, N. L. (2003) · Circulation · doi:10.1161/01.cir.0000043801.92580.79 · Cited by 131 · see citing works
Cardiac Arrhythmias in the Human Fetus
Kleinman, C. S., & Nehgme, R. (2004) · Pediatric Cardiology · doi:10.1007/s00246-003-0589-x · Cited by 128 · see citing works
Changes in the frequency power spectrum of fetal heart rate in the course of pregnancy
Leeuwen, P. V., Geue, D., Lange, S., Hatzmann, W., & Grönemeyer, D. H. W. (2003) · Prenatal Diagnosis · doi:10.1002/pd.723 · Cited by 118 · see citing works
An Estimate of Fetal Autonomic State by Spectral Analysis of Fetal Heart Rate Fluctuations
Karin, J., Hirsch, M., & Akselrod, S. (1993) · Pediatric Research · doi:10.1203/00006450-199308000-00005 · Cited by 116 · see citing works
Magnetocardiography in the diagnosis of fetal arrhythmia
Leeuwen, P. V., Halier, B., Bader, W., Geissler, J., Trowitzsch, E., & Grönemeyer, D. H. W. (1999) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.1999.tb08149.x · Cited by 104 · see citing works
Hendler, I., Blackwell, S. C., Treadwell, M. C., et al. (2004) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2004.03.064 · Cited by 79 · see citing works
Handbook for digital signal processing
(1993) · Choice Reviews Online · doi:10.5860/choice.31-2131 · Cited by 77 · see citing works
Biomagnetic systems for clinical use
Penna, S. D., DELGRATTA, C., Granata, C., Pasquarelli, A., Pizzella, V., Rossi, R., Russo, M., Torquatiand, K., & Erne, S. N. (2000) · Philosophical Magazine B · doi:10.1080/01418630008221960 · Cited by 73 · see citing works
Robust algorithms for principal component analysis
Yang, T.-N., & Wang, S. (1999) · Pattern Recognition Letters · doi:10.1016/s0167-8655(99)00060-4 · Cited by 66 · see citing works
Wakai, R. T., Lengle, J. M., & Leuthold, A. (2000) · Physics in Medicine and Biology · doi:10.1088/0031-9155/45/7/320 · Cited by 65 · see citing works
Prenatal Diagnosis of QT Prolongation by Magnetocardiography
Menéndez, T., Achenbach, S. S., Beinder, E., Hofbeck, M., SCHMID, O., Singer, H., Moshage, W. E. L., & Daniel, W. G. (2000) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2000.tb00950.x · Cited by 65 · see citing works
Recommended Standards for Fetal Magnetocardiography
Grimm, B., Haueisen, J., Huotilainen, M., Lange, S., Leeuwen, P. V., Menéndez, T., Peters, M. J., Schleußner, E., & Schneider, U. (2003) · Pacing and Clinical Electrophysiology · doi:10.1046/j.1460-9592.2003.00330.x · Cited by 63 · see citing works
Usefulness of magnetocardiography for the investigation of fetal arrhythmias
Menéndez, T., Achenbach, S. S., Beinder, E., Hofbeck, M., Klinghammer, L., Singer, H., Moshage, W. E. L., & Daniel, W. G. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01658-7 · Cited by 63 · see citing works
Independent component analysis: fetal signal reconstruction from magnetocardiographic recordings
Comani, S., Mantini, D., Pennesi, P., Lagatta, A., & Cancellieri, G. (2004) · Computer Methods and Programs in Biomedicine · doi:10.1016/j.cmpb.2003.12.005 · Cited by 46 · see citing works
Self-citationComani, S., Mantini, D., Lagatta, A., Esposito, F., Luzio, S. D., & Romani, G. L. (2004) · Physiological Measurement · doi:10.1088/0967-3334/25/5/019 · Cited by 44 · see citing works
Self-citationAssessment of Fetal Rhythm in Complete Congenital Heart Block by Magnetocardiography
Wakai, R. T., Leuthold, A. C., Cripe, L. H., & Martin, C. B. (2000) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2000.tb00896.x · Cited by 41 · see citing works
Grimm, B., Kähler, C., Schleußner, E., Schneider, U., Haueisen, J., & Seewald, H. J. (2003) · Early Human Development · doi:10.1016/s0378-3782(03)00079-3 · Cited by 29 · see citing works
Hosono, T., Chiba, Y., Shinto, M., Miyashita, S., Muramaki, K., Kandori, A., & Tsukada, K. (2000) · Fetal Diagnosis and Therapy · doi:10.1159/000053878 · Cited by 25 · see citing works
Sonographic assessment of fetal cardiac arrhythmias
Fyfe, D. A., Meyer, K. B., & Case, C. L. (1993) · Seminars in Ultrasound CT and MRI · doi:10.1016/s0887-2171(05)80103-9 · Cited by 18 · see citing works
Biomagnetic systems for clinical use
Penna, S. D. (2000) · Philosophical Magazine B · doi:10.1080/014186300254899 · Cited by 18 · see citing works
Hosono, T., Kanagawa, T., Chiba, Y., et al. (2002) · Fetal Diagnosis and Therapy · doi:10.1159/000065379 · Cited by 14 · see citing works
COMPARISON OF WAVELET TRANSFORM AND MATCHING PURSUIT IN THE ANALYSIS OF EEG AND MEG SIGNALS
Grątkowski, M., Haueisen, J., Schack, B., et al. (2003) · Biomedizinische Technik/Biomedical Engineering · doi:10.1515/bmte.2003.48.s1.186 · Cited by 14 · see citing works
PHASE SYNCHRONISATION - A MECHANISM FOR NEURAL INTEGRATION FOR EVENT-RELATED POTENTIALS
Schack, B., & Weiss, S. (2003) · Biomedizinische Technik/Biomedical Engineering · doi:10.1515/bmte.2003.48.s1.150 · Cited by 12 · see citing works
Spectral Analysis of Fetal Heart Rate Variability in Fetuses with Supraventricular Extrasystoles
Troeger, C., Schaub, A. F., BERNASCONI, P. P., et al. (2003) · Fetal Diagnosis and Therapy · doi:10.1159/000070811 · Cited by 8 · see citing works
Fetal magnetocardiogram recordings and power spectra analysis in biomagnetic arrhythmic signals
A. Kotini, P. A. A. (2001) · Journal of Obstetrics and Gynaecology · doi:10.1080/01443610120059905 · Cited by 6 · see citing works
[Fetal echocardiography: Part III. Fetal arrhythmia].
Chaoui, R., Bollmann, R., Hoffmann, H., et al. (1991) · PubMed · Cited by 5 · see citing works
Comani, S., Tartaro, A., Romani, G. L., et al. (2003) · Physica Medica · doi:10.1400/19257 · Cited by 5 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 4
- Kleinman CS, Donnerstein RL, Jaffe CC, et al. Fetal echocardiog- raphy: A tool for evaluation of in utero cardiac arrhythmias and monitoring of in utero therapy: Analysis of 71 patients. Am J Car- diol 1983; 51:237-243.
- Mantini D, Comani S, Pennesi P, et al. Fetal tailoring of the inde- pendent component analysis to multi-channel fMCG recordings for an optimal reconstruction of the fetal cardiac signal. Biomed Tech 2004; 48:186-188.
- Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate vari- ability. Eur Heart J 1996; 17:354-381.
- Comani S, Liberati M, Gabriele E, et al. Fetal intra-cardiac intervals for different gestational epochs as evaluated from fetal magnetocar- diograms. Biomed Tech 2004; 48:150-152.
Cited by
Sorted by citations
Clinical application of magnetocardiography
Fenici, R., Brisinda, D., & Meloni, A. M. (2005) · Expert Review of Molecular Diagnostics · doi:10.1586/14737159.5.3.291 · Cited by 174 · see citing works
Clinical magnetocardiography: the unshielded bet—past, present, and future
Brisinda, D., Fenici, P., & Fenici, R. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1232882 · Cited by 71 · see citing works
“The parallel research efforts carried out with shielded and unshielded MCG over the last three decades have enlarged the knowledge about the pros and cons of these two approaches and provided evidence of well-defined fields of clinical application, such as the emergency triage of patients with chest pain, the diagnosi…”
BackgroundSelf-citationWacker-Gussmann, A., Plankl, C., Sewald, M., Schneider, K.-T. M., Oberhoffer, R., & Lobmaier, S. M. (2018) · Journal of Perinatal Medicine · doi:10.1515/jpm-2017-0003 · Cited by 25 · see citing works
Harnessing the Heart’s Magnetic Field for Advanced Diagnostic Techniques
Elfouly, T., & Alouani, A. (2024) · Sensors · doi:10.3390/s24186017 · Cited by 19 · see citing works
- Authors
- COMANI, S., LIBERATI, M., MANTINI, D., GABRIELE, E., BRISINDA, D., DI LUZIO, S., FENICI, R., & LUCA ROMANI, G.
- Affiliations
- University of Chieti-Pescara (IT)
- Marche Polytechnic University (IT)
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- COMANI, SILVIA
- Venue
- Pacing and Clinical Electrophysiology
- Publisher
- Wiley
- Published
- 2004-12
- Volume
- 27
- Issue
- 12
- Pages
- 1647-1655
- ISSN
- 0147-8389 (ISSN-L)
- 1540-8159
- OpenAlex
- W1979379061
- Cited by
- 38
- References
- 37
- Citations by year
- 2024: 3 · 2023: 1 · 2020: 1 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 3.91
- Type
- journal article
- Language
- en
- Open access
- green
- lirias.kuleuven.be
- Licence
- Locations
- Pacing and Clinical Electrophysiology (publishedVersion)
- PubMed (publishedVersion)
- Lirias (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › ECG Monitoring and Analysis
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Keywords
- fetal arrhythmia, fetal magnetocardiography, supraventricular extrasystoles, atrioventricular block, fetal heart rate variability, maternal obesity, fetal growth restriction, oligohydramnios, fetal cardiac rhythm
- MeSH terms
- Adult, Algorithms, Arrhythmias, Cardiac, Electrocardiography, Female, Humans, Magnetics, Obesity, Pregnancy, Pregnancy Trimester, Third, Prenatal Diagnosis, Signal Processing, Computer-Assisted, Tachycardia, Supraventricular, Cardiotocography, Ventricular Premature Complexes, Atrial Premature Complexes, Principal Component Analysis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
