Efficacy and safety of ibutilide for the conversion of monomorphic atrial tachycardia
Abstract
BACKGROUND: Ibutilide is a class III antiarrhythmic drug, frequently used for conversion of atrial fibrillation and flutter. We studied the efficacy of ibutilide for acute conversion of monomorphic atrial tachycardia (monoAT) in a prospective, open label study in the intensive care unit of a cardiological clinic. METHODS: We examined 49 episodes of monoAT in 38 patients (19 men/19 women). Thirty-three patients (87%) suffered from structural heart disease. Twenty-three episodes occurred while on antiarrhythmic therapy with class I or III drugs. Patients with prolonged QT interval (except for patients with pretreatment with class III drugs), hypokalemia, left ventricular failure, and recent myocardial infarction were excluded. All patients received one or two doses of 1 mg ibutilide fumarate under continuous rhythm monitoring. RESULTS: Conversion to sinus rhythm occurred in 19 episodes (38.8%), in 6 episodes (12.2%) after the first dose. Conversion rate was significantly higher in patients with a short history of symptoms (66.6% vs 28.6%; P < 0.05), of documented arrhythmia (0.13 (0/5.7) vs 2.6 (0.38/23.5) months, median (interquartile range); P < 0.03), higher atrial rate (272 +/- 49 vs 207 +/- 36 beats/min (means +/- SD); P < 0.004), or without preexisting antiarrhythmic therapy (53.8% vs 21.7%; P < 0.02). No differences in conversion rates were found regarding gender, age, body mass index, left ventricular function, left atrial diameter, or underlying disease. In three episodes torsade de pointes occurred after ibutilide (6.1%), requiring defibrillation in two cases (4.1%). CONCLUSIONS: Ibutilide can be used for conversion of monoAT with a similar efficacy as for atrial fibrillation, but with a considerably lower efficacy compared to typical atrial flutter.
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Class Ia, Ic, and III drugs may work by prolonging the action potential or suppressing automaticity.
“Class Ia, Ic, and III drugs may work as well, by prolonging the action potential or suppressing automaticity.107,108,110”
From European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, endorsed by Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS), and Sociedad Latinoamericana de Estimulacion Cardiaca y Electrofisiologia (SOLAECE) (2017) · cites this paper as [110]
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2015 ACC/AHA/HRS Guideline for the Management of Adult Patients With Supraventricular Tachycardia
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- Authors
- EIDHER, U., FREIHOFF, F., KALTENBRUNNER, W., & STEINBACH, K.
- Affiliations
- Wilhelminen Hospital (AT)
- Corresponding author
- EIDHER, ULRIKE
- Venue
- Pacing and Clinical Electrophysiology
- Publisher
- Wiley
- Published
- 2006-04
- Volume
- 29
- Issue
- 4
- Pages
- 358-362
- ISSN
- 0147-8389 (ISSN-L)
- 1540-8159
- OpenAlex
- W2041209919
- Cited by
- 21
- References
- 14
- Citations by year
- 2025: 2 · 2024: 1 · 2022: 2 · 2020: 2 · 2019: 1 · 2016: 3 · 2015: 6
- FWCI
- 0.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pacing and Clinical Electrophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- ibutilide, conversion to sinus rhythm, class III antiarrhythmic agents, torsades de pointes, atrial flutter, atrial fibrillation, structural heart disease, antiarrhythmic therapy, atrial rate
- MeSH terms
- Anti-Arrhythmia Agents, Female, Humans, Male, Middle Aged, Risk Factors, Sulfonamides, Tachycardia, Ectopic Atrial, Treatment Outcome, Risk Assessment
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