The DOI matches its Crossref record; 140 of the 140 references it cites were found in a registry or an index.
Brugada Syndrome
Open accessAbstract
First introduced as a new clinical entity in 1992, the Brugada syndrome is associated with a relatively high risk of sudden death in young adults, and occasionally in children and infants. Recent years have witnessed a striking proliferation of papers dealing with the clinical and basic aspects of the disease. Characterized by a coved‐type ST‐segment elevation in the right precordial leads of the electrocardiogram (ECG), the Brugada syndrome has a genetic basis that thus far has been linked only to mutations in SCN5A, the gene that encodes the α‐subunit of the sodium channel. The Brugada ECG is often concealed, but can be unmasked or modulated by a number of drugs and pathophysiological states including sodium channel blockers, a febrile state, vagotonic agents, tricyclic antidepressants, as well as cocaine and propranolol intoxication. Average age at the time of initial diagnosis or sudden death is 40 ± 22, with the youngest patient diagnosed at 2 days of age and the oldest at 84 years. This review provides an overview of the clinical, genetic, molecular, and cellular aspects of the Brugada syndrome, incorporating the results of two recent consensus conferences. Controversies with regard to risk stratification and newly proposed pharmacologic strategies are discussed.
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Cites
Brugada, P., & Brugada, J. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90253-j · Cited by 3,331
Handbook of Experimental Pharmacology.
Meakin, J. W. (1971) · Archives of Internal Medicine · doi:10.1001/archinte.1971.00310230151026 · Cited by 1,959
Genetic basis and molecular mechanism for idiopathic ventricular fibrillation
Chen, Q., Kirsch, G. E., Zhang, D., Brugada, R., Brugada, J., Brugada, P., Potenza, D., Moya, A., Borggrefe, M., Breithardt, G., et al. (1998) · Nature · doi:10.1038/32675 · Cited by 1,831
Self-citationAntzelevitch, C., Brugada, P., Borggrefe, M., Brugada, J., Brugada, R., Corrado, D., Gussak, I., LeMarec, H., Nademanee, K., Perez Riera, A. R., et al. (2005) · Circulation · doi:10.1161/01.cir.0000152479.54298.51 · Cited by 1,807
Self-citationCardiac Malformation in Neonatal Mice Lacking Connexin43
Reaume, A. G., de Sousa, P. A., Kulkarni, S., Langille, B. L., Zhu, D., Davies, T. C., Juneja, S. C., Kidder, G. M., & Rossant, J. (1995) · Science · doi:10.1126/science.7892609 · Cited by 1,244
Yan, G.-X., & Antzelevitch, C. (1999) · Circulation · doi:10.1161/01.cir.100.15.1660 · Cited by 1,126
Self-citationNeural Crest Cells Contribute to Normal Aorticopulmonary Septation
Kirby, M. L., Gale, T. F., & Stewart, D. E. (1983) · Science · doi:10.1126/science.6844926 · Cited by 1,113
Natural History of Brugada Syndrome: Insights for Risk Stratification and Management
Priori, S. G., Napolitano, C., Gasparini, M., Pappone, C., Bella, P. D., Giordano, U., Bloise, R., Giustetto, C., De Nardis, R., Grillo, M., et al. (2002) · Circulation · doi:10.1161/hc1102.105288 · Cited by 1,034
Yan, G.-X., & Antzelevitch, C. (1998) · Circulation · doi:10.1161/01.cir.98.18.1928 · Cited by 988
Self-citationProposed Diagnostic Criteria for the Brugada Syndrome: Consensus Report
Wilde, A. A. M., Antzelevitch, C., Borggrefe, M., Brugada, J., Brugada, R., Brugada, P., Corrado, D., Hauer, R. N. W., Kass, R. S., Nademanee, K., et al. (2002) · Circulation · doi:10.1161/01.cir.0000034169.45752.4a · Cited by 827
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Cited by
J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge
Antzelevitch, C., Yan, G.-X., Ackerman, M. J., Borggrefe, M., Corrado, D., Guo, J., Gussak, I., Hasdemir, C., Horie, M., Huikuri, H., et al. (2016) · Heart Rhythm · doi:10.1016/j.hrthm.2016.05.024 · Cited by 621
Self-citationTp-e/QT ratio as an index of arrhythmogenesis
Gupta, P., Patel, C., Patel, H., Narayanaswamy, S., Malhotra, B., Green, J. T., & Yan, G.-X. (2008) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2008.07.016 · Cited by 616
The pathophysiological mechanism underlying Brugada syndrome
Wilde, A. A. M., Postema, P. G., Di Diego, J. M., Viskin, S., Morita, H., Fish, J. M., & Antzelevitch, C. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.07.012 · Cited by 345
Self-citationNam, G.-B., Ko, K.-H., Kim, J., Park, K.-M., Rhee, K.-S., Choi, K.-J., Kim, Y.-H., & Antzelevitch, C. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehp423 · Cited by 198
Self-citationKaufman, E. S. (2009) · Heart Rhythm · doi:10.1016/j.hrthm.2009.02.009 · Cited by 104
Metadata
- Authors
- ANTZELEVITCH, C.
- Venue
- Pacing and Clinical Electrophysiology
- Publisher
- Wiley
- Published
- 2006-10
- Volume
- 29
- Issue
- 10
- Pages
- 1130-1159
- ISSN
- 0147-8389 (ISSN-L)
- 1540-8159
- OpenAlex
- W4210965788
- Cited by
- 303
- References
- 140
- FWCI
- 14.22
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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