Cited by 90Atrial Fibrillation Management and OutcomesCardiac Arrhythmias and TreatmentsCardiac pacing and defibrillation studies

Preliminary results of a limited thoracotomy: new approach to treat atrial fibrillation

MCCLELLAND, JAMES H., DUKE, DAVID, REDDY, RAMAKOTA·2007·Journal of Cardiovascular Electrophysiology

Abstract

Objective: To determine efficacy of a new procedure combining epicardial bipolar radiofrequency (RF) pulmonary vein (PV) antrum isolation and ganglionated plexus (GP) ablation for treatment of atrial fibrillation (AF). Background: PV antrum electrical isolation and GP ablation have each been associated with elimination of AF. Both of these can be performed epicardially in a single combined surgical procedure, which may have advantages over endocardial ablation. Methods and Results: Twenty‐one subjects entered a prospective evaluation of limited thoracotomy epicardial bipolar PV antrum isolation, verified by PV recordings, with GP ablation, guided by GP mapping. Procedural success was defined as freedom from AF and antiarrhythmic agents during 1 year of follow‐up, including evaluation by prolonged continuous monitoring capable of detecting asymptomatic arrhythmias. All subjects had recordable PV potentials and GP activity prior to ablation. Circumferential epicardial bipolar RF eliminated PV potentials in 18 of 20 right and 14 of 20 left PV antra. This concurrently eliminated 79% of GP activity (125 of 159 active sites); nearly all remaining GP activity could then be eliminated using epicardial bipolar RF forceps. Fifteen of 20 (75%) subjects overall, and 14 of 16 (87.5%) subjects with paroxysmal or persistent AF had a successful procedure. Conclusion: Limited thoracotomy epicardial bipolar RF antrum isolation, verified by PV recordings, with GP ablation, guided by GP mapping, is effective treatment for AF and should be considered in patients with paroxysmal or persistent AF.

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Crossref · 10.1111/j.1540-8167.2007.00977.x

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Authors
MCCLELLAND, J. H., DUKE, D., & REDDY, R.
Corresponding author
MCCLELLAND, JAMES H.
Venue
Journal of Cardiovascular Electrophysiology
Publisher
Wiley
Published
2007-10-25
Volume
18
Issue
12
Pages
1289-1295
ISSN
  • 1045-3873 (ISSN-L)
  • 1540-8167
OpenAlex
W2050776096
Cited by
90
References
28
Citations by year
2024: 1 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 5 · 2016: 10 · 2015: 7 · 2014: 6 · 2013: 6 · 2012: 10
FWCI
7.28
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Cardiovascular Electrophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac pacing and defibrillation studies
Keywords
atrial fibrillation, limited thoracotomy, pulmonary vein antrum isolation, ganglionated plexus ablation, paroxysmal atrial fibrillation, persistent atrial fibrillation
MeSH terms
Adult, Aged, Aged, 80 and over, Atrial Fibrillation, Female, Ganglia, Heart Atria, Humans, Male, Middle Aged, Pilot Projects, Pulmonary Veins, Thoracotomy, Treatment Outcome, Catheter Ablation

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