Heterogeneous Expression of Potassium Currents and Pacemaker Currents Potentially Regulates Arrhythmogenesis of Pulmonary Vein Cardiomyocytes
Abstract
Introduction: The relationship between the determining factors and beating rates of pulmonary vein (PV) pacemaker cardiomyocytes has not been fully elucidated. The purposes of this study were to compare the electrophysiological characteristics between PV fast and slow pacemaker cardiomyocytes. Methods: Whole‐cell patch clamp was used to investigate the action potentials, transient outward currents (Ito), sustained outward potassium currents (IKsus), rapid delayed rectifier potassium currents (IKr), inward rectifier potassium current (IK1), pacemaker currents (If), and transient inward currents in isolated rabbit PV single fast (≥2.5 Hz) and slow (<2.5 Hz) pacemaker cardiomyocytes. Results: The fast PV pacemaker cardiomyocytes (n = 66) had lesser negative maximum diastolic potential (−53 ± 1 mV vs −59 ± 1 mV, P < 0.001) and larger slope of diastolic depolarization (0.31 ± 0.02 V/sec vs 0.09 ± 0.01 V/sec, P < 0.001) than slow PV pacemaker cardiomyocytes (n = 65). Moreover, the PV beating rates correlated well with the slope of diastolic depolarization and maximum diastolic potential with a linear regression. As compared to those in slow PV pacemaker cardiomyocytes, the fast PV pacemaker cardiomyocytes had smaller Ito and IK1, and larger If but with similar IKsus,IKr, and transient inward currents. However, only few fast (2/34) and slow (1/23) PV pacemaker cardiomyocytes contained barium‐sensitive hyperpolarization‐activated time‐dependent current (IKH). Conclusions and Implications: The fast and slow PV pacemaker had different electrophysiological characteristics. Ito, IK1, and If may regulate the beating rates of PV pacemaker cardiomyocytes.
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Some studies have suggested differences in AF genetics between women and men.
“some studies have suggested differences in AF genetics between women and men7–9.”
From Atrial fibrillation in women: epidemiology, pathophysiology, presentation, and prognosis (2016) · cites this paper as [7]
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- Authors
- CHEN, Y., PAN, N., CHENG, C., HIGA, S., CHEN, Y., & CHEN, S.
- Affiliations
- National Defense Medical Center (TW)
- Wan Fang Hospital (TW)
- Chi Mei Medical Center (TW)
- Taipei Veterans General Hospital (TW)
- Corresponding author
- CHEN, YI‐JEN
- ORCID
- CHEN, YAO‐CHANG
- Venue
- Journal of Cardiovascular Electrophysiology
- Publisher
- Wiley
- Published
- 2009-08-26
- Volume
- 20
- Issue
- 9
- Pages
- 1039-1045
- ISSN
- 1045-3873 (ISSN-L)
- 1540-8167
- OpenAlex
- W1979707365
- Cited by
- 49
- References
- 34
- Citations by year
- 2025: 1 · 2022: 4 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 8 · 2015: 2 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cardiovascular Electrophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Arrhythmias and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Keywords
- arrhythmogenesis, pacemaker current, potassium currents, transient outward current, inward rectifier potassium current, hyperpolarization-activated current, beating frequency, diastolic depolarization, action potential, atrial fibrillation
- MeSH terms
- Action Potentials, Animals, Arrhythmias, Cardiac, Biological Clocks, Cells, Cultured, Heart Conduction System, Membrane Potentials, Potassium, Pulmonary Veins, Rabbits, Potassium Channels, Ion Channel Gating, Myocytes, Cardiac
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