The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Drug‐Eluting Bioabsorbable Magnesium Stent
Abstract
Current stent technology is based on the use of permanent implants that remain life long in the vessel wall, far beyond the time required for the prosthesis to accomplish its main goals of sealing dissection and preventing wall recoil. With the possibility to implant long vessel segments using antiproliferative drugs to prevent restenosis, the practice of transforming the coronary vessels into stiff tubes with a full metal jacket covering all side branches and being unable to adjust to the long‐term wall changes, including wall remodeling with lumen ectasia becomes a serious concern. In this article, we describe the first biodegradable stent based on a magnesium alloy that allows controlled corrosion with release to the vessel wall and the blood stream of a natural body component such as magnesium with beneficial antithrombotic, antiarrhythmic, and antiproliferative properties. We also discuss the animal experiments and the initial clinical applications in 20 patients with implants below the knee, with final results soon to be released, and the plans for the first coronary study. The results of these last two studies will indicate whether the absence of a permanent implant and the antiproliferative properties shown in animals are sufficient to prevent the restenotic process in humans or whether the prosthesis must be modified by adding the biodegradable coating with conventional antiproliferative drugs.
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Biocorrosion of magnesium alloys: a new principle in cardiovascular implant technology?
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Self-citationInitial and 6-Month Results of Biodegradable Poly- l -Lactic Acid Coronary Stents in Humans
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Long-term assessment of a novel biodegradable paclitaxel-eluting coronary polylactide stent
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Cited by
On the mechanisms of biocompatibility
Williams, D. F. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2008.04.023 · Cited by 2,772
Recent advances on the development of magnesium alloys for biodegradable implants
Chen, Y., Xu, Z., Smith, C., & Sankar, J. (2014) · Acta Biomaterialia · doi:10.1016/j.actbio.2014.07.005 · Cited by 1,236
Erbel, R., Di Mario, C., Bartunek, J., Bonnier, J., de Bruyne, B., Eberli, F. R., Erne, P., Haude, M., Heublein, B., Horrigan, M., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60853-8 · Cited by 907
Self-citationCoronary stents: A materials perspective
Mani, G., Feldman, M. D., Patel, D., & Agrawal, C. M. (2007) · Biomaterials · doi:10.1016/j.biomaterials.2006.11.042 · Cited by 866
Novel Magnesium Alloys Developed for Biomedical Application: A Review
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Metadata
- Authors
- DI MARIO, C., GRIFFITHS, H., GOKTEKIN, O., PEETERS, N., VERBIST, J., BOSIERS, M., DELOOSE, K., HEUBLEIN, B., ROHDE, R., KASESE, V., ILSLEY, C., & ERBEL, R.
- Venue
- Journal of Interventional Cardiology
- Publisher
- Wiley
- Published
- 2004-11-11
- Volume
- 17
- Issue
- 6
- Pages
- 391-395
- ISSN
- 0896-4327 (ISSN-L)
- 1540-8183
- OpenAlex
- W2086490706
- Cited by
- 428
- References
- 12
- FWCI
- 13.63
- Type
- journal article
- Language
- en
- Open access
- closed
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- DI MARIO, C., GRIFFITHS, H., GOKTEKIN, O., PEETERS, N., VERBIST, J., BOSIERS, M., DELOOSE, K., HEUBLEIN, B., ROHDE, R., KASESE, V., ILSLEY, C., & ERBEL, R. (2004). Drug‐Eluting Bioabsorbable Magnesium Stent. Journal of Interventional Cardiology. https://doi.org/10.1111/j.1540-8183.2004.04081.x
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