Ethnic Differences in ST Height in the Multiethnic Study of Atherosclerosis
Open accessAbstract
Background: ST elevation in precordial leads has been associated with genetic syndromes of arrhythmias and sudden death. ST height data in different ethnic groups are limited. Methods: ST height was determined in 4612 African‐American, Chinese, Hispanic, and non‐Hispanic white men and women aged 45–84 years in the Multiethnic Study of Atherosclerosis (MESA). For leads I, II, and V 1 to V 6, ST height, measured at the J point and 60 ms after the J point, adjusted for covariates were compared between non‐Hispanic white and other ethnic groups using analysis of covariance (ANCOVA). Results: Among men, ST height was significantly different across all ethnic groups at both time points for all leads (P < 0.01), except at the J point for limb lead II (P = 0.2). Among women, differences were also significant at the J point and 60 ms past the J point (P < 0.01). ST height was lowest for non‐Hispanic whites in all leads and at both time points. At the J point, Chinese had the highest ST height for leads V 1 and V 2, whereas African Americans had the greatest ST height for leads I and V 3 to V 6. At 60 ms past the J point, Chinese men had the greatest ST height for lead I and V 1 to V 6; and Chinese women had greatest ST height for leads V 1 to V 3. Conclusions: There were significant differences in ST height among ethnic groups in all ECG leads. The physiological mechanisms and clinical significance of these differences and the possible association with arrhythmias require further study.
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- Authors
- Reddy, V. K., Gapstur, S. M., Prineas, R., Colangelo, L. A., Ouyang, P., & Kadish, A. H.
- Affiliations
- Northwestern University (US)
- Wake Forest University Health Sciences (US)
- Johns Hopkins University (US)
- ORCID
- Venue
- Annals of Noninvasive Electrocardiology
- Publisher
- Wiley
- Published
- 2008-10
- Volume
- 13
- Issue
- 4
- Pages
- 341-351
- ISSN
- 1082-720X (ISSN-L)
- 1542-474X
- PMC
- PMC2637518
- OpenAlex
- W1562997437
- Cited by
- 20
- References
- 26
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2014: 1 · 2013: 3 · 2012: 1
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Noninvasive Electrocardiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Touro Scholar (Touro College) (submittedVersion)
- Funders
- National Institutes of Health (n01hc95165-34-0-1, n01hc095169-003, n01hc95159-40-0-1)
- National Heart, Lung, and Blood Institute (N01 HC-95159, N01 HC95165, 1R01 HL075382 01, R01HL075382, N01 HC95169)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › ECG Monitoring and Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- ethnic differences, electrocardiogram, J point, precordial leads, sudden cardiac death, cardiac arrhythmias, African Americans, Chinese, Hispanic Americans, Multi-Ethnic Study of Atherosclerosis, sex differences
- MeSH terms
- Aged, Aged, 80 and over, Asian, Black or African American, Blood Pressure, Electrocardiography, Female, Heart Rate, Hispanic or Latino, Humans, Male, Middle Aged, Ventricular Function, Left, Electrophysiologic Techniques, Cardiac, Atherosclerosis
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