The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
MULLER'S RATCHET AND MUTATIONAL MELTDOWNS
Open accessAbstract
We extend our earlier work on the role of deleterious mutations in the extinction of obligately asexual populations. First, we develop analytical models for mutation accumulation that obviate the need for time-consuming computer simulations in certain ranges of the parameter space. When the number of mutations entering the population each generation is fairly high, the number of mutations per individual and the mean time to extinction can be predicted using classical approaches in quantitative genetics. However, when the mutation rate is very low, a fixation-probability approach is quite effective. Second, we show that an intermediate selection coefficient (s) minimizes the time to extinction. The critical value of s can be quite low, and we discuss the evolutionary implications of this, showing that increased sensitivity to mutation and loss of capacity for DNA repair can be selectively advantageous in asexual organisms. Finally, we consider the consequences of the mutational meltdown for the extinction of mitochondrial lineages in sexual species.
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Cites
The Genetics and Biology of Drosophila
(1978) · Food and Cosmetics Toxicology · doi:10.1016/s0015-6264(78)80200-4 · Cited by 3,755
Rapid evolution of animal mitochondrial DNA
Brown, W. M., George, M., & Wilson, A. C. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.4.1967 · Cited by 3,439
The relation of recombination to mutational advance
Muller, H. J. (1964) · Mutation Research · doi:10.1016/0027-5107(64)90047-8 · Cited by 2,512
Mitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy
Wallace, D. C., Singh, G., Lott, M. T., Hodge, J. A., Schurr, T. G., Lezza, A. M. S., Elsas, L. J., & Nikoskelainen, E. K. (1988) · Science · doi:10.1126/science.3201231 · Cited by 2,440
The double-strand-break repair model for recombination
Szostak, J. W., Orr-Weaver, T. L., Rothstein, R. J., & Stahl, F. W. (1983) · Cell · doi:10.1016/0092-8674(83)90331-8 · Cited by 2,437
Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies
Holt, I. J., Harding, A. E., & Morgan-Hughes, J. A. (1988) · Nature · doi:10.1038/331717a0 · Cited by 1,846
THE EVOLUTIONARY ADVANTAGE OF RECOMBINATION
Felsenstein, J. (1974) · Genetics · doi:10.1093/genetics/78.2.737 · Cited by 1,711
Mathematical Population Genetics
Baake, E., Ewens, W. J., & Wakolbinger, A. (2006) · Oberwolfach Reports · doi:10.4171/owr/2005/40 · Cited by 1,624
Mitochondrial Genetics: A Paradigm for Aging and Degenerative Diseases?
Wallace, D. C. (1992) · Science · doi:10.1126/science.1533953 · Cited by 1,262
ON THE PROBABILITY OF FIXATION OF MUTANT GENES IN A POPULATION
Kimura, M. (1962) · Genetics · doi:10.1093/genetics/47.6.713 · Cited by 1,208
Cited by
Why intraspecific trait variation matters in community ecology
Bolnick, D. I., Amarasekare, P., Araújo, M. S., Bürger, R., Levine, J. M., Novak, M., Rudolf, V. H. W., Schreiber, S. J., Urban, M. C., & Vasseur, D. A. (2011) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2011.01.009 · Cited by 2,372
Self-citationDomingo, E., Sheldon, J., & Perales, C. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05023-11 · Cited by 1,009
Judson, O. P., & Normark, B. B. (1996) · Trends in Ecology & Evolution · doi:10.1016/0169-5347(96)81040-8 · Cited by 549
MUTATIONAL MELTDOWNS IN SEXUAL POPULATIONS
Lynch, M., Conery, J., & Bürger, R. (1995) · Evolution · doi:10.1111/j.1558-5646.1995.tb04434.x · Cited by 481
Self-citationInheritance and recombination of mitochondrial genomes in plants, fungi and animals
Barr, C. M., Neiman, M., & Taylor, D. R. (2005) · New Phytologist · doi:10.1111/j.1469-8137.2005.01492.x · Cited by 382
Metadata
- Authors
- Gabriel, W., Lynch, M., & Bürger, R.
- Venue
- Evolution
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-12
- Volume
- 47
- Issue
- 6
- Pages
- 1744-1757
- ISSN
- 0014-3820 (ISSN-L)
- 1558-5646
- OpenAlex
- W2066227234
- Cited by
- 381
- References
- 38
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- green
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- Gabriel, W., Lynch, M., & Bürger, R. (1993). MULLER'S RATCHET AND MUTATIONAL MELTDOWNS. Evolution. https://doi.org/10.1111/j.1558-5646.1993.tb01266.x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
