The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
Candida biofilms on implanted biomaterials: a clinically significant problem
Abstract
In recent years there has been an increasing appreciation that microbial biofilms are ubiquitous, which has resulted in a number of studies on infectious diseases from a biofilm perspective. Biofilms are defined as structured microbial communities that are attached to a surface and encased in a matrix of exopolymeric material. A wide range of biomaterials used in clinical practice have been shown to support colonization and biofilm formation by Candida spp., and the increase in Candida infections in the last decades has almost paralleled the increase and widespread use of a broad range of medical implant devices, mainly in populations with impaired host defenses. Formation of Candida biofilms has important clinical repercussions because of their increased resistance to antifungal therapy and the ability of cells within biofilms to withstand host immune defenses. Further recognition and understanding of the role of Candida biofilms in human infection should help in the clinical management of these recalcitrant infections.
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In the citing paper
“In addition, Candida biofilms afford fungal cells a safe haven, constitute reservoirs for persistent sources of candidiasis, and can also negatively affect the function of implanted devices [29].”
From Antifungal therapy of Candida biofilms: Past, present and future (2023) · cites this paper as [29]
In the citing paper
“These biofilms exhibit greatly increased resistance to antifungal agents and an enhanced ability to withstand host immune defenses21.”
From Chiloscyphenol A derived from Chinese liverworts exerts fungicidal action by eliciting both mitochondrial dysfunction and plasma membrane destruction (2018) · cites this paper as [21]
In the citing paper
“A well-documented virulence factor of Candida species is the notable ability to form adherent structures, known as biofilms, on surfaces of medical devices [49–51].”
From Aprepitant, an antiemetic agent, interferes with metal ion homeostasis of Candida auris and displays potent synergistic interactions with azole drugs (2020) · cites this paper as [51]
In the citing paper
“The closely related species Candida dubliniensis, Candida parapsilosis, Candida tropicalis, and Candida krusei have all been implicated in biofilm-associated infections (73, 157, 187).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [157]
In the citing paper
“Candida glabrata (which, despite the name, lies well outside the CTG clade phylogenetically) forms thin biofilms in vitro (without hyphal cells) on biotic and abiotic surfaces associated with the human host (157).”
From Candida albicans Biofilms and Human Disease (2015) · cites this paper as [157]
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Metadata
- Authors
- Ramage, G., MartÃnez, J. P., & López-Ribot, J. L.
- Affiliations
- Glasgow Caledonian University (GB)
- Universitat de València (ES)
- ORCID
- Ramage, Gordon
- Venue
- FEMS Yeast Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-11
- Volume
- 6
- Issue
- 7
- Pages
- 979-986
- ISSN
- 1567-1356 (ISSN-L)
- 1567-1364
- OpenAlex
- W2126155024
- Cited by
- 575
- References
- 82
- Citations by year
- 2026: 16 · 2025: 23 · 2024: 16 · 2023: 24 · 2022: 19 · 2021: 34 · 2020: 37 · 2019: 28 · 2018: 36 · 2017: 37 · 2016: 35 · 2015: 43 · 2014: 38 · 2013: 42 · 2012: 34
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEMS Yeast Research (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- ResearchOnline (submittedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida biofilms, medical device-related infections, implant materials, antifungal resistance, exopolysaccharide matrix, host immune evasion
- MeSH terms
- Candida, Catheterization, Central Venous, Catheters, Indwelling, Dentures, Equipment and Supplies, Renal Dialysis, Humans, Biofilms, Prostheses and Implants
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