Clinical relevance of serum interleukin-6 in Crohn’s disease: single point measurements, therapy monitoring, and prediction of clinical relapse
Abstract
Objective To investigate the clinical relevance of interleukin-6 (IL-6) serum levels in patients with Crohn's disease (CD), single point IL-6 measurements in sera from consecutive CD patients and healthy donors (HD), as well as longitudinal measurements during the course of steroid therapy for active CD were performed. Patients with steroid-induced remission were followed until clinical relapse. Methods One hundred thirty-six CD patients without steroid or other immunosuppressive treatment within 2 months and surgical procedures within 3 months before study entry were investigated; 63 patients with active CD were enrolled into the follow-up program. Clinical activity was evaluated by the Crohn's disease activity index (CDAI) and serum IL-6 levels measured by enzyme-linked immunosorbent assay. Results IL-6 serum levels were significantly elevated in CD patients compared to HD (p Conclusions Serum IL-6 is a clinically relevant parameter for CD that correlates with inflammatory activity and implies a prognostic value after steroid-induced remission.
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There is a correlation between IL-6 and the severity of RA and other inflammatory and autoimmune diseases.
“In line with this notion, there is a correlation between IL-6 and the severity of RA and other inflammatory and autoimmune diseases (3, 260, 261).”
From IL-6 in inflammation, autoimmunity and cancer (2021) · cites this paper as [261]
Cites
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Intestinal permeability and the prediction of relapse in Crohn's disease
Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., & Lochs, H. (1993) · The Lancet · doi:10.1016/0140-6736(93)90882-h · Cited by 626 · see citing works
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Terzić, J., Grivennikov, S., Karin, E., & Karin, M. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.058 · Cited by 1,974 · see citing works
IL-6 in inflammation, autoimmunity and cancer
Hirano, T. (2021) · International Immunology · doi:10.1093/intimm/dxaa078 · Cited by 1,453 · see citing works
“In line with this notion, there is a correlation between IL-6 and the severity of RA and other inflammatory and auto-immune diseases (3, 260, 261).”
BackgroundRole of cytokines in inflammatory bowel disease
Sanchez-Muñoz, F., Dominguez-Lopez, A., & Yamamoto-Furusho, J. K. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.4280 · Cited by 699 · see citing works
Involvement of IL–6 in the pathogenesis of inflammatory bowel disease and colon cancer
Atreya, R., & Neurath, M. F. (2005) · Clinical Reviews in Allergy & Immunology · doi:10.1385/criai:28:3:187 · Cited by 324 · see citing works
IL-6 Induces NF-κB Activation in the Intestinal Epithelia
Wang, L., Walia, B., Evans, J., Gewirtz, A. T., Merlin, D., & Sitaraman, S. V. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.6.3194 · Cited by 243 · see citing works
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Phan, A., Joshi, P., Kadelka, C., & Friedberg, I. (2025) · Database · doi:10.1093/database/baaf036 · Cited by 2 · see citing works
- Authors
- Reinisch, W., Gasché, C., Tillinger, W., Wyatt, J., Lichtenberger, C., Willheim, M., Dejaco, C., Waldhör, T., Bakos, S., Vogelsang, H., Gangl, A., & Lochs, H.
- Affiliations
- University of Vienna (AT)
- Vienna General Hospital (AT)
- Charité – Universitätsmedizin Berlin (DE)
- Corresponding author
- Reinisch, Walter
- Venue
- American Journal of Gastroenterology
- Published
- 1999-08
- Volume
- 94
- Issue
- 8
- Pages
- 2156-2164
- ISSN
- 0002-9270 (ISSN-L)
- OpenAlex
- W2155785741
- Cited by
- 150
- References
- 2
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 11 · 2021: 11 · 2020: 7 · 2019: 3 · 2018: 8 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 7 · 2013: 3 · 2012: 5
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- Crohn's disease, interleukin-6, serum biomarkers, disease activity, CDAI, corticosteroid therapy, clinical relapse prediction, intestinal stenosis, bowel resection, prognostic factors
- MeSH terms
- Adult, Anti-Inflammatory Agents, Crohn Disease, Dose-Response Relationship, Drug, Drug Administration Schedule, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prednisolone, Recurrence, Interleukin-6, Treatment Outcome
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