Intestinal permeability and the prediction of relapse in Crohn's disease
Abstract
To see whether intestinal permeability (IP) predicted relapse in Crohn's disease, we measured IP in 72 patients with quiescent Crohn's disease using the lactulose-mannitol test. The permeability index (lactulose/mannitol) was significantly higher in patients than in controls (0.046 [SEM 0.005] vs 0.018 [SEM 0.002], respectively). Patients were followed for 1 year after the test. 26 of the 37 patients with raised permeability, but only 6 of the 35 with normal permeability relapsed within 1 year after the test (p < 0.001). The sensitivity of the permeability test as a predictor for relapse was 81%. A significant correlation was found between the value of the permeability index and the probability of relapse (p < 0.01). These results show that increases in intestinal permeability precede clinical relapses in Crohn's disease and so are an indicator of subclinical disease. The measurement of intestinal permeability may lead to a better understanding of the pathogenesis of Crohn's disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Other objective measures associated with disease activity for IBD, such as fecal calprotectin, gut permeability, or gut lavage fluid protein, have high sensitivity for the presence or absence of active disease.
“Other objective measures associated with disease activity for IBD such as fecal calprotectin 31 , gut permeability 32 or gut lavage fluid protein have high sensitivity for presence or absence of active disease 33 .”
From The Manitoba IBD Index: Evidence for a New and Simple Indicator of IBD Activity (2009) · cites this paper as [32]
Cites
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1992) · Springer series in statistics · doi:10.1007/978-1-4612-4380-9_25 · Cited by 45,232 · see citing works
Nonparametric Estimation from Incomplete Observations
Kaplan, E. L., & Meier, P. (1958) · Journal of the American Statistical Association · doi:10.1080/01621459.1958.10501452 · Cited by 39,158 · see citing works
(1990) · Choice Reviews Online · doi:10.5860/choice.27-3338 · Cited by 35,305 · see citing works
Evaluation of survival data and two new rank order statistics arising in its consideration.
Mantel, N. (1966) · PubMed · Cited by 7,516 · see citing works
Development of a Crohn's Disease Activity Index
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · Gastroenterology · doi:10.1016/s0016-5085(76)80163-1 · Cited by 3,152 · see citing works
Development of a Crohn's disease activity index. National Cooperative Crohn's Disease Study.
Best, W. R., Becktel, J. M., Singleton, J. W., & Kern, F. (1976) · PubMed · Cited by 3,147 · see citing works
Plackett, R. L., & Cox, D. R. (1971) · Journal of the Royal Statistical Society Series A (General) · doi:10.2307/2344247 · Cited by 2,273 · see citing works
European Cooperative Crohn's Disease Study (ECCDS): Results of drug treatment
Malchow, H. A., Ewe, K., Brandes, J. W., Goebell, H., Ehms, H., Sommer, H., & Jesdinsky, H. J. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90409-8 · Cited by 931 · see citing works
Evidence for continuous stimulation of interleukin-6 production in Crohn's disease
Groß, V., Andus, T., Caesar, I., Roth, M., & Schölmerich, J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90098-j · Cited by 293 · see citing works
A laboratory index for predicting relapse in asymptomatic patients with Crohn's disease
Brignola, C., Campieri, M., Bazzocchi, G., Farruggia, P., Tragnone, A., & Lanfranchi, G. A. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90206-4 · Cited by 159 · see citing works
Multivariate Interpretation of Clinical Laboratory Data.
Sampson, A. R., Albert, A., & Harris, E. K. (1988) · Journal of the American Statistical Association · doi:10.2307/2288902 · Cited by 136 · see citing works
Intestinal permeability in Crohn's disease.
Murphy, M., EASTHAM, E. J., NELSON, R. L., Pearson, A., & Laker, M. F. (1989) · Archives of Disease in Childhood · doi:10.1136/adc.64.3.321 · Cited by 76 · see citing works
Assessment of the lactulose-mannitol test in Crohn's disease.
Andre, F., Andre, C., Emery, Y., Forichon, J., Descos, L., & Minaire, Y. (1988) · Gut · doi:10.1136/gut.29.4.511 · Cited by 67 · see citing works
Delahunty, T., & Hollander, D. (1986) · Clinical Chemistry · doi:10.1093/clinchem/32.8.1542 · Cited by 38 · see citing works
Acute Phase Proteins in Chronic Inflammatory Bowel Disease in Childhood
Campbell, C., Walker-Smith, J. A., Hindocha, P., & Adinolfí, M. (1982) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-198201020-00007 · Cited by 32 · see citing works
Liquid-chromatographic measurement of urinary monosaccharides.
D'Amboise, M., Hanai, T., & Noël, D. (1980) · Clinical Chemistry · doi:10.1093/clinchem/26.9.1348 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Intestinal mucosal barrier function in health and disease
Turner, J. R. (2009) · Nature reviews. Immunology · doi:10.1038/nri2653 · Cited by 3,952 · see citing works
Microbial translocation is a cause of systemic immune activation in chronic HIV infection
Brenchley, J. M., Price, D. A., Schacker, T. W., Asher, T. E., Silvestri, G., Rao, S., Kazzaz, Z., Bornstein, E., Lambotte, O., Altmann, D., et al. (2006) · Nature Medicine · doi:10.1038/nm1511 · Cited by 3,559 · see citing works
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
Peterson, L. W., & Artis, D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3608 · Cited by 3,191 · see citing works
Inflammatory bowel disease: Etiology and pathogenesis
Fiocchi, C. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70381-6 · Cited by 2,059 · see citing works
Intestinal barrier function: molecular regulation and disease pathogenesis
Groschwitz, K. R., & Hogan, S. P. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.038 · Cited by 1,775 · see citing works
Immunopathogenesis of IBD: current state of the art
de Souza, H. S. P., & Fiocchi, C. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.186 · Cited by 1,551 · see citing works
Assche, G. V., Dignass, A. U., Panés, J., Beaugerie, L., Karagiannis, J. A., Allez, M., Ochsenkühn, T., Orchard, T., Rogler, G., Louis, E. J., et al. (2010) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2009.12.003 · Cited by 1,444 · see citing works
The intestinal epithelial barrier: a therapeutic target?
Odenwald, M. A., & Turner, J. R. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.169 · Cited by 1,288 · see citing works
Zeißig, S., Bürgel, N., Günzel, D., Richter, J. F., Mankertz, J., Wahnschaffe, U., Kroesen, A. J., Zeitz, M., Fromm, M., & Schulzke, J. (2006) · Gut · doi:10.1136/gut.2006.094375 · Cited by 1,218 · see citing works
Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity
Clarke, T. B., Davis, K. M., Lysenko, E. S., Zhou, A. Y., Yu, Y., & Weiser, J. N. (2010) · Nature Medicine · doi:10.1038/nm.2087 · Cited by 1,154 · see citing works
Intestinal permeability: an overview
Bjarnason, I., Macpherson, A., & Hollander, D. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90708-4 · Cited by 927 · see citing works
Tight Junction Pore and Leak Pathways: A Dynamic Duo
Shen, L., Weber, C. R., Raleigh, D. R., Yu, D., & Turner, J. R. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142150 · Cited by 867 · see citing works
Probiotic bacteria and intestinal epithelial barrier function
Ohland, C., & MacNaughton, W. K. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00243.2009 · Cited by 808 · see citing works
Tibble, J. A., Sigthorsson, G., Bridger, S., Fagerhol, M. K., & Bjarnason, I. (2000) · Gastroenterology · doi:10.1053/gast.2000.8523 · Cited by 759 · see citing works
Paracellular permeability and tight junction regulation in gut health and disease
Horowitz, A., Chánez-Paredes, S. D., Haest, X., & Turner, J. R. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00766-3 · Cited by 725 · see citing works
Guo, S., Al–Sadi, R., Said, H. M., & Ma, T. Y. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.10.014 · Cited by 722 · see citing works
Michielan, A., & D’Incà, R. (2015) · Mediators of Inflammation · doi:10.1155/2015/628157 · Cited by 709 · see citing works
Wang, F., Graham, W. V., Wang, Y., Witkowski, E. D., Schwarz, B. T., & Turner, J. R. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62264-x · Cited by 692 · see citing works
Martini, E., Krug, S. M., Siegmund, B., Neurath, M. F., & Becker, C. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2017.03.007 · Cited by 668 · see citing works
Ait-Belgnaoui, A., Durand, H., Cartier, C., Chaumaz, G., Eutamene, H., Ferrier, L., Houdeau, E., Fioramonti, J., Bueno, L., & Theodorou, V. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.03.024 · Cited by 612 · see citing works
Epithelial Barriers in Homeostasis and Disease
Marchiando, A. M., Graham, W. V., & Turner, J. R. (2010) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.4.110807.092135 · Cited by 612 · see citing works
Importance of disrupted intestinal barrier in inflammatory bowel diseases
Salim, S. Y., & Söderholm, J. D. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21403 · Cited by 602 · see citing works
Mechanisms of action of probiotics: Recent advances
Ng, S. C., Hart, A. L., Kamm, M. A., Stagg, A. J., & Knight, S. C. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20602 · Cited by 596 · see citing works
Molecular Basis of Epithelial Barrier Regulation
Turner, J. R. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060681 · Cited by 542 · see citing works
Kuo, W., Zuo, L., Odenwald, M. A., Madha, S., Singh, G., Gurniak, C. B., Abraham, C., & Turner, J. R. (2021) · Gastroenterology · doi:10.1053/j.gastro.2021.08.047 · Cited by 537 · see citing works
Landy, J., Ronde, E., English, N., Clark, S. K., Hart, A. L., Knight, S. C., Ciclitira, P. J., & Al-Hassi, H. O. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i11.3117 · Cited by 507 · see citing works
Stange, E. F., Travis, S. P. L., Vermeire, S., Beglinger, C., Kupcinkas, L., Geboes, K., Barakauskiene, A., Villanacci, V., Herbay, A. V., Warren, B. F., et al. (2006) · Gut · doi:10.1136/gut.2005.081950a · Cited by 506 · see citing works
Sturgeon, C., & Fasano, A. (2016) · Tissue Barriers · doi:10.1080/21688370.2016.1251384 · Cited by 497 · see citing works
A porous defense: the leaky epithelial barrier in intestinal disease
Clayburgh, D. R., Shen, L., & Turner, J. R. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700050 · Cited by 496 · see citing works
Fasano, A. (2020) · F1000Research · doi:10.12688/f1000research.20510.1 · Cited by 496 · see citing works
Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells
Prasad, S. B., Mingrino, R., Kaukinen, K., Hayes, K. L., Powell, R. M., MacDonald, T. T., & Collins, J. E. (2005) · Laboratory Investigation · doi:10.1038/labinvest.3700316 · Cited by 493 · see citing works
Probiotic Escherichia coli Nissle 1917 inhibits leaky gut by enhancing mucosal integrity
Ukena, S. N., Singh, A., Dringenberg, U., Engelhardt, R., Seidler, U., Hansen, W., Bleich, A., Bruder, D., Franzke, A., Rogler, G., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001308 · Cited by 482 · see citing works
Fasano, A., & Shea-Donohue, T. (2005) · Nature Clinical Practice Gastroenterology & Hepatology · doi:10.1038/ncpgasthep0259 · Cited by 399 · see citing works
Borrelli, O., Cordischi, L., Cirulli, M., Paganelli, M., Labalestra, V., Uccini, S., Russo, P. M., & Cucchiara, S. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.03.010 · Cited by 469 · see citing works
Su, L., Shen, L., Clayburgh, D. R., Nalle, S. C., Sullivan, E. A., Meddings, J. B., Abraham, C., & Turner, J. R. (2009) · Gastroenterology · doi:10.1053/j.gastro.2008.10.081 · Cited by 455 · see citing works
Ma, T. Y., Boivin, M. A., Ye, D., Pedram, A., & Said, H. M. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00412.2004 · Cited by 452 · see citing works
IL-1β and the Intestinal Epithelial Tight Junction Barrier
Kaminsky, L. W., Al–Sadi, R., & Ma, T. Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.767456 · Cited by 441 · see citing works
Sözener, Z. Ç., Öztürk, B. Ö., Çerçi, P., Türk, M., Akın, B. G., Akdiş, M., Altıner, S., Yücel, Ü. Ö., Öğülür, İ., Mitamura, Y., et al. (2022) · Allergy · doi:10.1111/all.15240 · Cited by 442 · see citing works
Mucosal antibodies in inflammatory bowel disease are directed against intestinal bacteria.
Macpherson, A. J., Khoo, U. Y., Forgács, I., Philpott‐Howard, J., & Bjarnason, I. (1996) · Gut · doi:10.1136/gut.38.3.365 · Cited by 435 · see citing works
Clayburgh, D. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24970 · Cited by 419 · see citing works
Inflammatory and Microbiota-Related Regulation of the Intestinal Epithelial Barrier
Barbara, G., Barbaro, M. R., Fuschi, D., Palombo, M., Falangone, F., Cremon, C., Marasco, G., & Stanghellini, V. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.718356 · Cited by 420 · see citing works
Intestinal barrier in inflammatory bowel disease
Antoni, L. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i5.1165 · Cited by 416 · see citing works
Loss of the Tight Junction Protein ZO-1 in Dextran Sulfate Sodium Induced Colitis
Poritz, L. S., Garver, K. I., Green, C., Fitzpatrick, L. R., Ruggiero, F. M., & Koltun, W. A. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2006.07.050 · Cited by 414 · see citing works
Pandolfino, J. E., Ghosh, S. K., Rice, J. P., Clarke, J. O., Kwiatek, M. A., & Kahrilas, P. J. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2007.01532.x · Cited by 412 · see citing works
Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease
Suenaert, P., Bulteel, V., Lemmens, L., Noman, M., Geypens, B. J., Assche, G. V., Geboes, K. J., Ceuppens, J. L., & Rutgeerts, P. J. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05914.x · Cited by 402 · see citing works
Kießlich, R., Duckworth, C. A., Moussata, D., Gloeckner, A., Lim, L. G., Goetz, M., Pritchard, D. M., Galle, P. R., Neurath, M. F., & Watson, A. J. M. (2011) · Gut · doi:10.1136/gutjnl-2011-300695 · Cited by 394 · see citing works
Su, L., Nalle, S. C., Shen, L., Turner, E. S., Singh, G., Breskin, L. A., Khramtsova, E. A., Khramtsova, G. F., Tsai, P., Fu, Y., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.011 · Cited by 393 · see citing works
Zolotarevsky, Y., Hecht, G. A., Koutsouris, A., Gonzalez, D. E., Quan, C., Tom, J., Mrsny, R. J., & Turner, J. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.34235 · Cited by 385 · see citing works
Intestinal Permeability Defects: Is It Time to Treat?
Odenwald, M. A., & Turner, J. R. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.07.001 · Cited by 366 · see citing works
Cytoskeletal Regulation of Epithelial Barrier Function During Inflammation
Ivanov, A. I., Parkos, C. A., & Nusrat, A. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100168 · Cited by 366 · see citing works
Bühner, S., Büning, C., Genschel, J., Kling, K., Herrmann, D., Dignass, A., Kuechler, I., Krueger, S., Schmidt, H. H.-J., & Lochs, H. (2005) · Gut · doi:10.1136/gut.2005.065557 · Cited by 366 · see citing works
Self-citationInflammatory bowel disease is associated with changes of enterocytic junctions
Gaßler, N., Rohr, C. M., Schneider, A., Kartenbeck, J., Bach, A., Obermüller, N., Otto, H. F., & Autschbach, F. (2001) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2001.281.1.g216 · Cited by 363 · see citing works
Myosin light chain kinase: pulling the strings of epithelial tight junction function
Cunningham, K. E., & Turner, J. R. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06526.x · Cited by 345 · see citing works
Giloteaux, L., Goodrich, J. K., Walters, W. A., Levine, S. M., Ley, R. E., & Hanson, M. R. (2016) · Microbiome · doi:10.1186/s40168-016-0171-4 · Cited by 339 · see citing works
Duchmann, R., Schmitt, E., Knolle, P. A., Büschenfelde, K. M. Z., & Neurath, M. F. (1996) · European Journal of Immunology · doi:10.1002/eji.1830260432 · Cited by 338 · see citing works
Voderholzer, W. A., Beinhoelzl, J., Rogalla, P., Murrer, S., Schachschal, G., Lochs, H., & Ortner, M.-A. (2005) · Gut · doi:10.1136/gut.2004.040055 · Cited by 330 · see citing works
Self-citationInvolvement of IL–6 in the pathogenesis of inflammatory bowel disease and colon cancer
Atreya, R., & Neurath, M. F. (2005) · Clinical Reviews in Allergy & Immunology · doi:10.1385/criai:28:3:187 · Cited by 324 · see citing works
The tight junction in inflammatory disease: communication breakdown
Edelblum, K. L., & Turner, J. R. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.06.022 · Cited by 313 · see citing works
Genetics of Crohn disease, an archetypal inflammatory barrier disease
Schreiber, S., Rosenstiel, P. C., Albrecht, M., Hampe, J., & Krawczak, M. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1607 · Cited by 306 · see citing works
Wang, F., Schwarz, B. T., Graham, W. V., Wang, Y., Su, L., Clayburgh, D. R., Abraham, C., & Turner, J. R. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.08.022 · Cited by 305 · see citing works
MicroRNA Regulation of Intestinal Epithelial Tight Junction Permeability
Ye, D., Guo, S., Al–Sadi, R., & Ma, T. Y. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.005 · Cited by 303 · see citing works
The intestinal barrier, an arbitrator turned provocateur in IBD
Mehandru, S., & Colombel, J. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-00399-w · Cited by 303 · see citing works
Blair, S. A., Kane, S. V., Clayburgh, D. R., & Turner, J. R. (2006) · Laboratory Investigation · doi:10.1038/labinvest.3700373 · Cited by 298 · see citing works
Chakaroun, R., Massier, L., & Kovacs, P. L. (2020) · Nutrients · doi:10.3390/nu12041082 · Cited by 297 · see citing works
Weber, C. R., Raleigh, D. R., Su, L., Shen, L., Sullivan, E. A., Wang, Y., & Turner, J. R. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.064808 · Cited by 296 · see citing works
Irvine, E. J., & Marshall, J. K. (2000) · Gastroenterology · doi:10.1053/gast.2000.20231 · Cited by 286 · see citing works
Zhang, H.-L., Yu, L.-X., Yang, W., Tang, L., Lin, Y., Wu, H., Zhai, B., Tan, Y.-X., Shan, L., Liu, Q., et al. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.06.011 · Cited by 281 · see citing works
Claudin-2 as a mediator of leaky gut barrier during intestinal inflammation
Luettig, J., Rosenthal, R., Barmeyer, C., & Jd, S. (2015) · Tissue Barriers · doi:10.4161/21688370.2014.977176 · Cited by 281 · see citing works
IBD immunopathogenesis: A comprehensive review of inflammatory molecules
Park, J. H., Peyrin‐Biroulet, L., Eisenhut, M., & Shin, J. I. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.02.013 · Cited by 280 · see citing works
The digestive neuronal–glial–epithelial unit: a new actor in gut health and disease
Neunlist, M., Landeghem, L. V., Mahé, M. M., Derkinderen, P., Varannes, S. B. D., & Rolli‐Derkinderen, M. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.221 · Cited by 277 · see citing works
New Approaches for Bacteriotherapy: Prebiotics, New-Generation Probiotics, and Synbiotics
Patel, R., & DuPont, H. L. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ177 · Cited by 272 · see citing works
Meddings, J. B., & Swain, M. G. (2000) · Gastroenterology · doi:10.1053/gast.2000.18152 · Cited by 269 · see citing works
Intestinal Permeation and Gastrointestinal Disease
DeMeo, M. T., Mutlu, E., Keshavarzian, A., & Tobin, M. C. (2002) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200204000-00003 · Cited by 269 · see citing works
Rawat, M., Nighot, M., Al–Sadi, R., Gupta, Y. A., Viszwapriya, D., Yochum, G. S., Koltun, W. A., & Ma, T. Y. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.06.038 · Cited by 268 · see citing works
Riddington, D. W. (1996) · JAMA · doi:10.1001/jama.1996.03530370045029 · Cited by 265 · see citing works
Duchmann, R., May, E., Heike, M., Knolle, P. A., Neurath, M. F., & BÜSCHENFELDE, K.-H. M. Z. (1999) · Gut · doi:10.1136/gut.44.6.812 · Cited by 258 · see citing works
Intestinal permeability, leaky gut, and intestinal disorders
Hollander, D. (1999) · Current Gastroenterology Reports · doi:10.1007/s11894-999-0023-5 · Cited by 255 · see citing works
Tumour necrosis factor α and interleukin 1β in relapse of Crohn's disease
Schreiber, S., Nikolaus, S., Hampe, J., Hämling, J., Koop, I., Groessner, B., Lochs, H., & Raedler, A. (1999) · The Lancet · doi:10.1016/s0140-6736(98)03339-x · Cited by 252 · see citing works
Self-citationCorticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat
Santos, J., Saunders, P. R., Hanssen, N. P. M., Yang, P., Yates, D. A., Groot, J. A., & Perdue, M. H. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.277.2.g391 · Cited by 251 · see citing works
Caradonna, L., Amati, L., Magrone, T., Pellegrino, N. M., Jirillo, E., & Caccavo, D. (2000) · Journal of Endotoxin Research · doi:10.1177/09680519000060030101 · Cited by 247 · see citing works
Yonker, L. M., Gilboa, T., Ogata, A. F., Senussi, Y., Lazarovits, R., Boribong, B. P., Bartsch, Y. C., Loiselle, M., Rivas, M. N., Porritt, R. A., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci149633 · Cited by 246 · see citing works
Nighot, P. K., Hu, C.-A. A., & Ma, T. Y. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.597492 · Cited by 244 · see citing works
Gut permeability and mucosal inflammation: bad, good or context dependent
Ahmad, R., Sorrell, M. F., Batra, S. K., Dhawan, P., & Singh, A. B. (2017) · Mucosal Immunology · doi:10.1038/mi.2016.128 · Cited by 243 · see citing works
The Role of Intestinal Permeability in Gastrointestinal Disorders and Current Methods of Evaluation
Vanuytsel, T., Tack, J. F., & Farré, R. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.717925 · Cited by 225 · see citing works
Inflammatory Bowel Disease and the Apical Junctional Complex
Bruewer, M., Samarin, S., & Nusrat, A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1326.017 · Cited by 222 · see citing works
Intestinal Permeability Test As A Predictor of Clinical Course in Crohn's Disease
Renata D'Incà, Leo, V. D., Corrao, G., Martines, D., D’Odorico, A., Mestriner, C., Venturi, C., Longo, G., & Sturniolo, G. C. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01444.x · Cited by 218 · see citing works
Al–Sadi, R., Ye, D., Said, H. M., & Ma, T. Y. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100371 · Cited by 217 · see citing works
Tight junctions on the move: molecular mechanisms for epithelial barrier regulation
Shen, L. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06613.x · Cited by 213 · see citing works
Can Calprotectin Predict Relapse Risk in Inflammatory Bowel Disease?
Renata D'Incà, Pont, E. D., Leo, V. D., Benazzato, L., Martinato, M., Lamboglia, F., Oliva, L., & Sturniolo, G. C. (2008) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2008.01870.x · Cited by 210 · see citing works
Alhouayek, M., Lambert, D. M., Delzenne, N. M., Cani, P. D., & Muccioli, G. G. (2011) · The FASEB Journal · doi:10.1096/fj.10-176602 · Cited by 208 · see citing works
Schreiber, S., Rosenstiel, P. C., Hampe, J., Nikolaus, S., Groessner, B., Schottelius, A., Kühbacher, T., Hämling, J., Fölsch, U. R., & Seegert, D. (2002) · Gut · doi:10.1136/gut.51.3.379 · Cited by 207 · see citing works
Chronic stress impairs rat growth and jejunal epithelial barrier function: role of mast cells
Santos, J., Benjamin, M. A., Yang, P., Prior, T., & Perdue, M. H. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.278.6.g847 · Cited by 205 · see citing works
Saunders, P. R., Santos, J., Hanssen, N. P. M., Yates, D. A., Groot, J. A., & Perdue, M. H. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1013204612762 · Cited by 198 · see citing works
Groschwitz, K. R., Ahrens, R., Osterfeld, H., Gurish, M. F., Han, X., Åbrink, M., Finkelman, F. D., Pejler, G., & Hogan, S. P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906372106 · Cited by 196 · see citing works
Secondulfo, M., Iafusco, D., Carratu, R., deMagistris, L., Sapone, A., Generoso, M., Mezzogiorno, A., Sasso, F. C., Cartenı̀, M., Rosa, R. D., et al. (2003) · Digestive and Liver Disease · doi:10.1016/j.dld.2003.09.016 · Cited by 193 · see citing works
Zinc Supplementation Tightens “Leaky Gut” in Crohn’s Disease
Sturniolo, G. C., Leo, V. D., Ferronato, A., D’Odorico, A., & Renata D'Incà (2001) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200105000-00003 · Cited by 192 · see citing works
Vermeire, S., Peeters, M., VLIETINCK, R. F., Joossens, S. B. A., Hond, E. D., Bulteel, V., Bossuyt, X., Geypens, B. J., & Rutgeerts, P. J. (2001) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200102000-00002 · Cited by 184 · see citing works
Vilela, E. G., Ferrari, M. D. L. A., Tôrres, H. O. D. G., Pinto, A. G., Aguirre, A. C. C., Martins, F. P., Goulart, E. M. A., & da Cunha, A. S. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520801943354 · Cited by 183 · see citing works
Schwarz, B. T., Wang, F., Shen, L., Clayburgh, D. R., Su, L., Wang, Y., Fu, Y., & Turner, J. R. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.02.052 · Cited by 178 · see citing works
Intracellular MLCK1 diversion reverses barrier loss to restore mucosal homeostasis
Graham, W. V., He, W., Marchiando, A. M., Zha, J., Singh, G., Li, H.-S., Biswas, A., Ong, M. L. D. M., Jiang, Z.-H., Choi, W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0393-7 · Cited by 176 · see citing works
- Authors
- Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., & Lochs, H.
- Corresponding author
- Lochs, H.
- ORCID
- Waldhoer, T.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1993-06
- Volume
- 341
- Issue
- 8858
- Pages
- 1437-1439
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2080195364
- Cited by
- 626
- References
- 16
- Citations by year
- 2026: 6 · 2025: 19 · 2024: 12 · 2023: 15 · 2022: 25 · 2021: 25 · 2020: 21 · 2019: 17 · 2018: 19 · 2017: 22 · 2016: 23 · 2015: 23 · 2014: 24 · 2013: 17 · 2012: 26
- FWCI
- 4.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Keywords
- Crohn's disease, intestinal permeability, recurrence prediction, lactulose/mannitol test, permeability index, subclinical disease, pathogenesis, inflammatory bowel disease
- MeSH terms
- Adult, Crohn Disease, Female, Humans, Intestinal Mucosa, Lactulose, Male, Mannitol, Permeability, Predictive Value of Tests, Recurrence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
