The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Small intestinal bacterial overgrowth in human cirrhosis is associated with systemic endotoxemia
Abstract
OBJECTIVES: Systemic endotoxemia has been implicated in various pathophysiological sequelae of chronic liver disease. One of its potential causes is increased intestinal absorption of endotoxin. We therefore examined the association of small intestinal bacterial overgrowth with systemic endotoxemia in patients with cirrhosis. METHODS: Fifty-three consecutive patients with cirrhosis (Child-Pugh group A, 23; group B, 18; group C, 12) were included. Jejunal secretions were cultivated quantitatively and systemic endotoxemia determined by the chromogenic Limulus amoebocyte assay. Patients were followed up for 1 yr. RESULTS: Small intestinal bacterial overgrowth, defined as > or = 10(5) total colony forming units per milliliter of jejunal secretions, was present in 59% of patients and strongly associated with acid suppressive therapy. The mean plasma endotoxin level was 0.86 +/- 0.48 endotoxin units/ml (range = 0.03-1.44) and was significantly associated with small intestinal bacterial overgrowth (0.99 vs 0.60 endotoxin units/ml, p = 0.03). During the 1-yr follow-up, seven patients were lost to follow up or underwent liver transplantation and 12 patients died. Multivariate Cox regression showed Child-Pugh group to be the only predictor for survival. CONCLUSIONS: Small intestinal bacterial overgrowth in cirrhotic patients is common and associated with systemic endotoxemia. The clinical relevance of this association remains to be defined.
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“In addition to alterations in bacterial composition, there is evidence for bacterial overgrowth in the upper gastrointestinal tract, which in turn is associated with increased circulating LPS levels 87.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [87]
In the citing paper
“as a consequence of small intestinal bacterial overgrowth (SIBO),30,31”
From The Gut Microbiome and the Brain (2014) · cites this paper as [30]
Citations
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Metadata
- Authors
- Bauer, T. M., Schwacha, H., Steinbruckner, B., Brinkmann, F. E., Ditzen, A. K., Aponte, J. J., Pelz, K., Berger, D., Kist, M., & Blum, H. E.
- Affiliations
- University of Freiburg (DE)
- University Medical Center Freiburg (DE)
- Hospital Clínic de Barcelona (ES)
- University Hospital Ulm (DE)
- Venue
- The American Journal of Gastroenterology
- Published
- 2002-09
- Volume
- 97
- Issue
- 9
- Pages
- 2364-2370
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W1987665619
- Cited by
- 211
- References
- 43
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 7 · 2023: 13 · 2022: 6 · 2021: 18 · 2020: 12 · 2019: 9 · 2018: 14 · 2017: 13 · 2016: 16 · 2015: 14 · 2014: 12 · 2013: 5 · 2012: 8
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- small intestinal bacterial overgrowth, liver cirrhosis, endotoxin, acid-suppressive therapy, Child-Pugh score, survival, chronic liver disease
- MeSH terms
- Adult, Aged, Female, Follow-Up Studies, Humans, Jejunum, Liver Cirrhosis, Male, Middle Aged, Predictive Value of Tests, Severity of Illness Index, Time Factors, Colony Count, Microbial, Survival Rate, Endotoxemia
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