Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophaegeal varices, and hyperdynamic circulation.

Lin, Ren-Shin; Lee, Fa-Yauh; Lee, Shou-Dong; Tsai, Yang-Te; Lin, Han Chieh; Rei-Hwa, Lu; Wan-Ching, Hsu; Cheng-Chun, Huang; Sun-Sang, Wang; Kwang-Juei, Lo

doi:10.1016/0168-8278(95)80424-2

Cited by 355Liver Disease and TransplantationSepsis Diagnosis and TreatmentAlcohol Consumption and Health Effects

Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophaegeal varices, and hyperdynamic circulation.

Lin, Ren-Shin, Lee, Fa-Yauh, Lee, Shou-Dong, Tsai, Yang-Te, Lin, Han Chieh, Rei-Hwa, Lu, Wan-Ching, Hsu, Cheng-Chun, Huang +2 more·1995·Journal of Hepatology

DOI 10.1016/0168-8278(95)80424-2

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Abstract

Plasma endotoxin levels were investigated using a quantitative Limulus assay in patients with chronic liver diseases and correlated with the severity of liver diseases, the presence of esophageal varices, and hemodynamic parameters. The plasma endotoxin levels were significantly higher in chronic hepatitis patients with acute exacerbation (10.1 +/- 1.3 pg/ml, n = 13, p < 0.05) and patients with cirrhosis (7.0 +/- 0.7 pg/ml, n = 126, p < 0.05) than in healthy subjects (2.9 +/- 0.2 pg/ml, n = 45). Chronic hepatitis patients (n = 30) had plasma endotoxin levels which were similar to those in healthy subjects (4.6 +/- 0.5 vs. 2.9 +/- 0.2 pg/ml, p > 0.05) but lower than those in chronic hepatitis patients with acute exacerbation (4.6 +/- 0.5 vs. 10.1 +/- 1.3 pg/ml, p < 0.05). Endotoxemia (plasma endotoxin level > 5.7 pg/ml) was found in 27%, 85% and 41% of patients with chronic hepatitis, chronic hepatitis with acute exacerbation, and cirrhosis, respectively. In patients with cirrhosis, the plasma endotoxin levels progressively increased in relation to the severity of liver dysfunction (Pugh's class A/B/C = 4.9 +/- 0.5/7.9 +/- 1.4/10.2 +/- 2.0 pg/ml, p < 0.05). In contrast, plasma endotoxin levels were comparable between patients with cirrhosis with and without esophageal varices (p > 0.05). Chronic hepatitis patients with acute exacerbation (no collaterization) had much higher plasma endotoxin levels than those in patients with cirrhosis and large varices (p < 0.05), whereas compensated patients with cirrhosis and large esophageal varices had plasma endotoxin levels similar to those seen in chronic hepatitis patients (no collaterization) (p > 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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Mean portal vein lipopolysaccharide levels rise with cirrhosis severity, from below 3 pg/ml in healthy volunteers to 4.9, 7.9 and 10.2 pg/ml in Child-Turcotte-Pugh stages A, B and C.
“Mean portal vein LPS levels increase in chronic liver injury from <3 pg/ml in healthy volunteers to 4.9 pg/ml, 7.9 pg/ml and 10.2 pg/ml in patients with Child–Turcotte-Pugh cirrhosis stage A, B and C, respectively24.”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [24]
High circulating lipopolysaccharide levels in mice and patients with chronic liver disease and hepatocellular carcinoma demonstrate a leaky gut during multiple stages of chronic liver disease and hepatocarcinogenesis.
“High circulating LPS levels in mice and patients with CLD as well as in HCC14,24,77,78 demonstrate the presence of a leaky gut during multiple stages of CLD and hepatocarcinogenesis (FIG. 1).”
From The gut microbiome and liver cancer: mechanisms and clinical translation (2017) · cites this paper as [24]

Transection of the oesophagus for bleeding oesophageal varices
Pugh, R. N. H., Murray-Lyon, I. M., Dawson, J. L., Pietroni, M. C., & Williams, R. (1973) · Journal of British Surgery · doi:10.1002/bjs.1800600817 · Cited by 7,941 · see citing works
Peripheral arterial vasodilation hypothesis: A proposal for the initiation of renal sodium and water retention in cirrhosis
Schrier, R. W., Arroyo, V., Bernardi, M., Epstein, M., Henriksen, J. H., & Rodés, J. (1988) · Hepatology · doi:10.1002/hep.1840080532 · Cited by 1,616 · see citing works
Biosynthesis of nitric oxide from l-arginine
Moncada, S., Palmer, R. M. J., & Higgs, E. A. (1989) · Biochemical Pharmacology · doi:10.1016/0006-2952(89)90403-6 · Cited by 1,211 · see citing works
The cardiovascular response of normal humans to the administration of endotoxin.
Suffredini, A., Fromm, R., Parker, M., Brenner, M., Kovacs, J., Wesley, R., & Parrillo, J. (1989) · New England Journal of Medicine · doi:10.1056/nejm198908033210503 · Cited by 1,133 · see citing works
Prediction of variceal hemorrhage by esophageal endoscopy
Beppu, K., Inokuchi, K., Koyanagi, N., Nakayama, S., Sakata, H., Kitano, S., & Kobayashi, M. (1981) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(81)73224-3 · Cited by 758 · see citing works
Hyperdynamic circulation in cirrhosis: A role for nitric oxide?
Vallance, P., & Moncada, S. (1991) · The Lancet · doi:10.1016/0140-6736(91)91384-7 · Cited by 615 · see citing works
Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock
Rees, D. D., Cellek, S., Palmer, R. M. J., & Moncada, S. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)80068-3 · Cited by 590 · see citing works
Thermodilution cardiac output determination with a single flow-directed catheter
Forrester, J. S., Ganz, W., Diamond, G. A., McHugh, T., Chonette, D., & Swan, H. J. C. (1972) · American Heart Journal · doi:10.1016/0002-8703(72)90429-2 · Cited by 500 · see citing works
Increased serum nitrite and nitrate levels in patients with cirrhosis: relationship to endotoxemia
Guarner, C., Soriano, G., Tomas, A., Bulbena, O., Novella, M. T., Balanzo, J., Vilardell, F., Mourelle, M., & Moncada, S. (1993) · Hepatology · doi:10.1002/hep.1840180520 · Cited by 489 · see citing works
Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay
Fukui, H., Brauner, B., Bode, J. C., & Bode, C. (1991) · Journal of Hepatology · doi:10.1016/0168-8278(91)90933-3 · Cited by 461 · see citing works
Loss of vascular responsiveness induced by endotoxin involves L-arginine pathway
Julou‐Schaeffer, G., Gray, G. A., Fleming, I., Schott, C., Parratt, J. R., & Stoclet, J. C. (1990) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1990.259.4.h1038 · Cited by 461 · see citing works
Hyperdynamic circulation in portal-hypertensive rat model: a primary factor for maintenance of chronic portal hypertension
Vorobioff, J., Bredfeldt, J. E., & Groszmann, R. J. (1983) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1983.244.1.g52 · Cited by 437 · see citing works
Endotoxin levels measured by a chromogenic assay in portal, hepatic and peripheral venous blood in patients with cirrhosis
Lumsden, A. B., Henderson, M. J., & Kutner, M. H. (1988) · Hepatology · doi:10.1002/hep.1840080207 · Cited by 427 · see citing works
New function for high density lipoproteins. Their participation in intravascular reactions of bacterial lipopolysaccharides.
Ulevitch, R. J., Johnston, A. R., & Weinstein, D. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109610 · Cited by 298 · see citing works
The Kidney in liver disease
Epstein, M. (1996) · Hanley & Belfus eBooks · Cited by 297 · see citing works
Wedged and free hepatic venous pressure measured with a balloon catheter
Groszmann, R. J., Glickman, M. G., Blei, A. T., Storer, E. H., & Conn, H. O. (1979) · Gastroenterology · doi:10.1016/0016-5085(79)90330-5 · Cited by 249 · see citing works
Septic shock. Hemodynamics and pathogenesis.
Parker, M. M., & Parrillo, J. E. (1984) · PubMed · Cited by 225 · see citing works
Chromogenic Substrates for Horseshoe Crab Clotting Enzyme
Iwanaga, S., Morita, T., Harada, T., Nakamura, S., Niwa, M., Takada, K., Kimura, T., & Sakakibara, S. (2009) · Haemostasis · doi:10.1159/000214260 · Cited by 204 · see citing works
Uptake by liver cells of endotoxin following its intravenous injection.
Dj, R., van der Meulen, J., Brouwer, A., Mj, H., Mauw, B. J., Jc, V. D. P., & Wisse, E. (1981) · PubMed · Cited by 188 · see citing works
Portal Venous and Systemic Endotoxaemia in Patients without Liver Disease and Systemic Endotoxaemia in Patients with Cirrhosis
Prytz, H., Holst-Christensen, J., KORNER, B., & Liehr, H. (1976) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1976.12097199 · Cited by 179 · see citing works
Administration of Nω-nitro-l-arginine ameliorates portal-systemic shunting in portal-hypertensive rats
Lee, F., Colombato, L., Albillos, A., & Groszmann, R. J. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90152-3 · Cited by 161 · see citing works
Self-citation
Acute exacerbation in chronic type B hepatitis: Comparison between HBeAg and antibody-positive patients
Liaw, Y., Tai, D., Chu, C., Pao, C. C., & Chen, T. (1987) · Hepatology · doi:10.1002/hep.1840070106 · Cited by 156 · see citing works
Temporal relationship of peripheral vasodilatation, plasma volume expansion and the hyperdynamic circulatory state in portal-hypertensive rats
Colombato, L., Albillos, A., & Groszmann, R. J. (1992) · Hepatology · doi:10.1002/hep.1840150224 · Cited by 147 · see citing works
Interaction of lipopolysaccharides with plasma high-density lipoprotein in rats
Freudenberg, M. A., Bøg-Hansen, T. C., Back, U., & Galanos, C. (1980) · Infection and Immunity · doi:10.1128/iai.28.2.373-380.1980 · Cited by 146 · see citing works
Endotoxemia, encephalopathy, and mortality in cirrhotic patients.
Bigatello, L. M., Broitman, S. A., Fattori, L., Di Paoli, M., Pontello, M. M., Bevilacqua, G., & Nespoli, A. (1987) · PubMed · Cited by 143 · see citing works
Vasodilatation and sodium retention in prehepatic portal hypertension
Albillos, A., Colombato, L., & Groszmann, R. J. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)90179-3 · Cited by 137 · see citing works
Nω-Nitro-L-arginine Administration Corrects Peripheral Vasodilation and Systemic Capillary Hypotension and Ameliorates Plasma Volume Expansion and Sodium Retention in Portal Hypertensive Rats
Lee, F., Colombato, L., Albillos, A., & Groszmann, R. J. (1993) · Hepatology · doi:10.1002/hep.1840170116 · Cited by 113 · see citing works
Self-citation
Reticuloendothelial system and hepatocytic function in fulminant hepatic failure.
Canalese, J., Gove, C. D., Gimson, A. E., Wilkinson, S. P., WARDLE, E. N., & Williams, R. L. (1982) · Gut · doi:10.1136/gut.23.4.265 · Cited by 102 · see citing works
Uptake and deacylation of bacterial lipopolysaccharides by macrophages from normal and endotoxin-hyporesponsive mice
Munford, R. S., & Hall, C. L. (1985) · Infection and Immunity · doi:10.1128/iai.48.2.464-473.1985 · Cited by 82 · see citing works
Fate of 51Cr-labeled lipopolysaccharide in tissue culture cells and livers of normal mice
Zlydaszyk, J. C., & Moon, R. J. (1976) · Infection and Immunity · doi:10.1128/iai.14.1.100-105.1976 · Cited by 78 · see citing works
Evidence for endotoxin binding capacity of human Gc-globulin and transferrin
Berger, D., & Beger, H. G. (1987) · Clinica Chimica Acta · doi:10.1016/0009-8981(87)90247-6 · Cited by 62 · see citing works
Lack of effects of isosorbide-5-mononitrate on hepatic hemodynamics in HBsAg-positive cirrhosis
Tsai, Y., Lee, F., Lin, H.-C., Chang, T., Lay, C., Wang, S.-S., Kong, C., Lee, S.-D., & Lo, K. (1989) · Hepatology · doi:10.1002/hep.1840100305 · Cited by 48 · see citing works
Self-citation
Chromogenic Endotoxin Assay in Plasma. Selection of Plasma Pretreatment and Production of Standard Curves
Fukui, H., Brauner, B., Bode, J. C., & Bode, C. (1989) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1989.27.12.941 · Cited by 44 · see citing works
Septic shock. Hemodynamics and pathogenesis
Parker, M. M. (1983) · JAMA · doi:10.1001/jama.250.24.3324 · Cited by 41 · see citing works
Endotoxemia in a Series of 104 Patients with Chronic Liver Diseases: Prevalence and Significance
Gaeta, G. B., Perna, P., Adinolfi, L. E., Utili, R., & Ruggiero, G. (2009) · Digestion · doi:10.1159/000198756 · Cited by 37 · see citing works
Endotoxins and the Pathogenesis of Hepatic and Gastrointestinal Diseases
Liehr, H. (1982) · Springer eBooks · doi:10.1007/978-3-642-68307-7_3 · Cited by 26 · see citing works
THE INFLUENCE OF PORTOSYSTEMIC SHUNT OPERATION ON IMMUNOGLOBULINS AND ESCHERICHIA COLI ANTIBODIES IN PATIENTS WITH CIRRHOSIS OF THE LIVER
Prytz, H., Bjørneboe, M., Johansen, T., & Ørskov, F. (1974) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1974.tb00976.x · Cited by 26 · see citing works
The relationship between endotoxin and the phagocytic activity of the reticuloendothelial system.
Kuratsune, H., Koda, T., & Kurahori, T. (1983) · PubMed · Cited by 26 · see citing works
Endotoxin and the hyperdynamic circulation of portal vein—ligated rats
Mehta, R., Gottstein, J. H., Zeller, P. W., Lichtenberg, R., & Blei, A. T. (1990) · Hepatology · doi:10.1002/hep.1840120513 · Cited by 24 · see citing works
Deacylation of bacterial lipopolysaccharide in rat hepatocytes in vitro.
Fukuda, I., Tanamoto, K., Kanegasaki, S., YAJIMA, Y., & Goto, Y. (1989) · PubMed Central · Cited by 14 · see citing works

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Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works
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Dapito, D. H., Mencin, A., Gwak, G.-Y., Pradere, J.-P., Jang, M.-K., Mederacke, I., Caviglia, J. M., Khiabanian, H., Adeyemi, A., Bataller, R., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.007 · Cited by 1,346 · see citing works
Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance
Albillos, A., Lario, M., & Álvarez-Mon, M. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.08.010 · Cited by 1,242 · see citing works
Pathological bacterial translocation in liver cirrhosis
Wiest, R., Lawson, M. A., & Geuking, M. B. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.07.044 · Cited by 815 · see citing works
Enteric dysbiosis associated with a mouse model of alcoholic liver disease
Yan, A. W., Fouts, D. E., Brandl, J., Stärkel, P., Torralba, M., Schott, E., Tsukamoto, H., Nelson, K. E., Brenner, D. A., & Schnabl, B. (2011) · Hepatology · doi:10.1002/hep.24018 · Cited by 791 · see citing works
The gut microbiome and liver cancer: mechanisms and clinical translation
Yu, L.-X., & Schwabe, R. F. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.72 · Cited by 634 · see citing works
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Zitvogel, L., Ayyoub, M., Routy, B., & Kroemer, G. (2016) · Cell · doi:10.1016/j.cell.2016.03.001 · Cited by 478 · see citing works
Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation
Su, G. L. (2002) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00550.2001 · Cited by 481 · see citing works
Gut Microbiota, Lipopolysaccharides, and Innate Immunity in the Pathogenesis of Obesity and Cardiovascular Risk
Manco, M., Putignani, L., & Bottazzo, G. F. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0030 · Cited by 479 · see citing works
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Wang, R., Tang, R., Li, B., Ma, X., Schnabl, B., & Tilg, H. (2021) · Cellular & Molecular Immunology · doi:10.1038/s41423-020-00592-6 · Cited by 466 · see citing works
Increased lipopolysaccharide binding protein in cirrhotic patients with marked immune and hemodynamic derangement
Albillos, A., de la Hera, A., González, M., Moya, J. L., Calleja, J. L., Monserrat, J., Ruíz-del-Árbol, L., & Álvarez‐Mon, M. (2003) · Hepatology · doi:10.1053/jhep.2003.50038 · Cited by 445 · see citing works
Role of innate immunity and the microbiota in liver fibrosis: crosstalk between the liver and gut
Seki, E., & Schnabl, B. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.219691 · Cited by 440 · see citing works
Toll-Like Receptor Signaling in the Liver
Schwabe, R. F., Seki, E., & Brenner, D. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.01.038 · Cited by 404 · see citing works
Sepsis in cirrhosis: report on the 7th meeting of the International Ascites Club
Wong, F. S.-H., Bernardi, M., Balk, R., Christman, B., Moreau, R., Garcia-Tsao, G., Patch, D., Soriano, G., Hoefs, J., & Navasa, M. (2005) · Gut · doi:10.1136/gut.2004.038679 · Cited by 390 · see citing works
Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis
Bátkai, S., Járai, Z., Wagner, J. A., Goparaju, S. K., Varga, K., Liu, J., Wang, L., Mirshahi, F., Khanolkar, A. D., Makriyannis, A., et al. (2001) · Nature Medicine · doi:10.1038/89953 · Cited by 376 · see citing works
Bacterial translocation: Overview of mechanisms and clinical impact
Balzan, S. M. P., Quadros, C. A., de Cleva, R., Zilberstein, B., & Cecconello, I. (2007) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2007.04933.x · Cited by 370 · see citing works
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Cirrhotic Cardiomyopathy: Getting to the Heart of the Matter
Ma, Z., & Lee, S. S. (1996) · Hepatology · doi:10.1002/hep.510240226 · Cited by 345 · see citing works
Self-citation
Toll-like receptors as targets in chronic liver diseases
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Non-selective betablocker therapy decreases intestinal permeability and serum levels of LBP and IL-6 in patients with cirrhosis
Reiberger, T., Ferlitsch, A., Payer, B. A., Mandorfer, M., Heinisch, B. B., Hayden, H., Lammert, F., Trauner, M. A., Peck‐Radosavljevic, M., & Vogelsang, H. (2012) · Journal of Hepatology · doi:10.1016/j.jhep.2012.12.011 · Cited by 328 · see citing works
Infection, coagulation, and variceal bleeding in cirrhosis
Thalheimer, U., Triantos, C. K., Samonakis, D. N., Patch, D., & Burroughs, A. K. (2005) · Gut · doi:10.1136/gut.2004.048181 · Cited by 317 · see citing works
Bacterial translocation and changes in the intestinal microbiome in mouse models of liver disease
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Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility
Wiest, R., Das, S., Cadelina, G. W., García–Tsao, G., Milstien, S., & Groszmann, R. J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7458 · Cited by 305 · see citing works
Persistent Organic Pollutants Modify Gut Microbiota–Host Metabolic Homeostasis in Mice Through Aryl Hydrocarbon Receptor Activation
Zhang, L., Nichols, R. G., Correll, J. B., Murray, I. A., Tanaka, N., Smith, P. B. W., Hubbard, T. D., Sebastian, A., Albert, I. U., Hatzakis, E., et al. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1409055 · Cited by 299 · see citing works
Systematic review: portal vein thrombosis in cirrhosis
Tsochatzis, E. A., Senzolo, M., Germani, G., Gatt, A., & Burroughs, A. K. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.04182.x · Cited by 284 · see citing works
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Shawcross, D. L., Sharifi, Y., Canavan, J. B., Yeoman, A. D., Abeles, R. D., Taylor, N. J., Auzinger, G. M., Bernal, W. E., & Wendon, J. A. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.07.045 · Cited by 277 · see citing works
Methods to determine intestinal permeability and bacterial translocation during liver disease
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Chlorogenic acid reduces liver inflammation and fibrosis through inhibition of toll-like receptor 4 signaling pathway
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Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy
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The pathophysiology of thrombocytopenia in chronic liver disease
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Rasaratnam, B., Kaye, D. M., Jennings, G., Dudley, F. J., & Chin-Dusting, J. P. F. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-139-3-200308050-00008 · Cited by 215 · see citing works
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Small intestinal bacterial overgrowth in human cirrhosis is associated with systemic endotoxemia
Bauer, T. M., Schwacha, H., Steinbruckner, B., Brinkmann, F. E., Ditzen, A. K., Aponte, J. J., Pelz, K., Berger, D., Kist, M., & Blum, H. E. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05791.x · Cited by 211 · see citing works
Commensal microbiota is hepatoprotective and prevents liver fibrosis in mice
Mazagova, M., Wang, L., Anfora, A. T., Wissmueller, M., Lesley, S. A., Miyamoto, Y., Eckmann, L., Dhungana, S., Pathmasiri, W., Sumner, S., et al. (2015) · The FASEB Journal · doi:10.1096/fj.14-259515 · Cited by 199 · see citing works
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Cesaro, C., Tiso, A., Del Prete, A., Cariello, R., Tuccillo, C., Cotticelli, G., del Vecchio Blanco, C., & Loguercio, C. (2011) · Digestive and Liver Disease · doi:10.1016/j.dld.2010.10.015 · Cited by 182 · see citing works
Peripheral Blood Mononuclear Cell Expression of Toll–Like Receptors and Relation to Cytokine Levels in Cirrhosis
Riordan, S. M., Skinner, N. A., Nagree, A., McCallum, H., McIver, C. J., Kurtovic, J., Hamilton, J. A., Bengmark, S., Williams, R. L., & Visvanathan, K. (2003) · Hepatology · doi:10.1053/jhep.2003.50180 · Cited by 167 · see citing works
Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation
Nicoletti, A., Ponziani, F. R., Biolato, M., Valenza, V., Marrone, G., Sganga, G., Gasbarrini, A., Miele, L., & Grieco, A. (2019) · World Journal of Gastroenterology · doi:10.3748/wjg.v25.i33.4814 · Cited by 170 · see citing works
Intestinal decontamination improves liver haemodynamics in patients with alcohol‐related decompensated cirrhosis
VLACHOGIANNAKOS, J., SAVERIADIS, A. S., VIAZIS, N., THEODOROPOULOS, I., FOUDOULIS, K., MANOLAKOPOULOS, S., RAPTIS, S., & KARAMANOLIS, D. G. (2009) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2009.03958.x · Cited by 163 · see citing works
Liver Steatosis, Gut-Liver Axis, Microbiome and Environmental Factors. A Never-Ending Bidirectional Cross-Talk
Ciaula, A. D., Baj, J., Garruti, G., Celano, G., Angelis, M. D., Wang, H. H., Palo, D. M. D., Bonfrate, L., Wang, D. Q. ‐., & Portincasa, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9082648 · Cited by 164 · see citing works
Cardiac electrophysiological abnormalities in patients with cirrhosis
Zambruni, A., Trevisani, F., Caraceni, P., & Bernardi, M. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2005.10.034 · Cited by 161 · see citing works
Liver Sinusoidal Endothelial Cell: An Update
Maretti-Mira, A. C., & DeLeve, L. D. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1617455 · Cited by 161 · see citing works
Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities
Mock, E. D., Gagestein, B., & van der Stelt, M. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101194 · Cited by 158 · see citing works
Toll-like Receptor 4 and Hepatic Fibrogenesis
Pradere, J.-P., Troeger, J., Dapito, D., Mencin, A., & Schwabe, R. (2010) · Seminars in Liver Disease · doi:10.1055/s-0030-1255353 · Cited by 158 · see citing works
Infectious Threats, the Intestinal Barrier, and Its Trojan Horse: Dysbiosis
Iacob, S. A., & Iacob, D. G. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01676 · Cited by 152 · see citing works
Role of Gut Dysbiosis in Liver Diseases: What Have We Learned So Far?
Fukui, H. (2019) · Diseases · doi:10.3390/diseases7040058 · Cited by 151 · see citing works
Interplay of cardiovascular mediators, oxidative stress and inflammation in liver disease and its complications
Mátyás, C., Haskó, G., Liaudet, L., Trojnár, E., & Pacher, P. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0433-5 · Cited by 152 · see citing works
Soluble CD 163, a marker of Kupffer cell activation, is related to portal hypertension in patients with liver cirrhosis
Grønbæk, H., Sandahl, T. D., Mortensen, C., Vilstrup, H., Møller, H. J., & Møller, S. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2012.05134.x · Cited by 148 · see citing works
Endotoxemia contributes to the immune paralysis in patients with cirrhosis
Lin, C.-Y., Tsai, I.-F., Ho, Y.-P., Huang, C.-T., Lin, Y.-C., Lin, C.-J., Tseng, S.-C., Lin, W.-P., Chen, W.-T., & Sheen, I.-S. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2006.12.018 · Cited by 145 · see citing works
LPS-induced TNF-α factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease
Ceccarelli, S., Panera, N., Mina, M., Gnani, D., Stefanis, C. D., Crudele, A., Rychlicki, C., Petrini, S., Bruscalupi, G., Agostinelli, L., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5163 · Cited by 141 · see citing works
The role of gut-liver axis in the pathogenesis of liver cirrhosis and portal hypertension
Seo, Y. S., & Shah, V. H. (2012) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2012.18.4.337 · Cited by 139 · see citing works
Abnormal intestinal permeability and microbiota in patients with autoimmune hepatitis.
Lin, R., Zhou, L., Zhang, J., & Wang, B. (2015) · PubMed Central · Cited by 141 · see citing works
Self-citation
Regulation of wound healing and organ fibrosis by toll-like receptors
Huebener, P., & Schwabe, R. F. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.11.017 · Cited by 140 · see citing works
Bacterial translocation in patients with liver cirrhosis: physiology, clinical consequences, and practical implications
Ponziani, F. R., Zocco, M. A., Cerrito, L., Gasbarrini, A., & Pompili, M. (2018) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2018.1481747 · Cited by 139 · see citing works
Toll-Like Receptor Signaling and Liver Fibrosis
Aoyama, T., Paik, Y., & Seki, E. (2010) · Gastroenterology Research and Practice · doi:10.1155/2010/192543 · Cited by 139 · see citing works
Rifaximin Improves Systemic Hemodynamics and Renal Function in Patients With Alcohol-Related Cirrhosis and Ascites
Kalambokis, G. N., Mouzaki, A., Rodi, M., Pappas, K., Fotopoulos, A., Xourgia, X., & Tsianos, E. V. (2012) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2012.02.025 · Cited by 130 · see citing works
Hyperdynamic circulation in patients with cirrhosis: direct measurement of nitric oxide levels in hepatic and portal veins
Battista, S., Bar, F., Mengozzi, G., Zanon, E., Grosso, M., & Molino, G. (1997) · Journal of Hepatology · doi:10.1016/s0168-8278(97)80012-8 · Cited by 130 · see citing works
Baterial Translocation in Humans
Lichtman, S. N. (2001) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200107000-00001 · Cited by 126 · see citing works
Gut-liver Axis and Microbiota in NAFLD: Insight Pathophysiology for Novel Therapeutic Target
Miele, L., Marrone, G., Lauritano, C., Cefalo, C., Gasbarrini, A., Day, C., & Grieco, A. (2012) · Current Pharmaceutical Design · doi:10.2174/1381612811319290011 · Cited by 131 · see citing works
Effect of intravenous albumin on endotoxin removal, cytokines, and nitric oxide production in patients with cirrhosis and spontaneous bacterial peritonitis
Chen, T.-A., Tsao, Y.-C., Chen, A., Lo, G., Lin, C., Yu, H., Cheng, L., Hsu, P., & Tsai, W. (2009) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520902719273 · Cited by 123 · see citing works
Microbial Translocation in Chronic Liver Diseases
Pinzone, M. R., Celesia, B. M., Rosa, M. D., Cacopardo, B. S., & Nunnari, G. (2012) · International Journal of Microbiology · doi:10.1155/2012/694629 · Cited by 119 · see citing works
Toll-Like Receptor 2–Mediated Intestinal Injury and Enteric Tumor Necrosis Factor Receptor I Contribute to Liver Fibrosis in Mice
Hartmann, P., Haimerl, M., Mazagova, M., Brenner, D. A., & Schnabl, B. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.099 · Cited by 118 · see citing works
Metagenomics of the Human Body
Nelson, K. E. (2010) · Springer eBooks · doi:10.1007/978-1-4419-7089-3 · Cited by 117 · see citing works
Endocannabinoids acting at CB1receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic rats
Bátkai, S., Mukhopadhyay, P., Harvey-White, J. D., Kechrid, R., Pacher, P., & Kunos, G. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00538.2007 · Cited by 118 · see citing works
Leaky Gut and Gut-Liver Axis in Liver Cirrhosis: Clinical Studies Update
Fukui, H. (2020) · Gut and Liver · doi:10.5009/gnl20032 · Cited by 115 · see citing works
Altered immune function of monocytes in different stages of patients with acute on chronic liver failure
Xing, T., Li, L., Cao, H., & Huang, J. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03259.x · Cited by 113 · see citing works
The intestinal flora and bacterial infection in cirrhosis
Riordan, S. M., & Williams, R. L. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.08.001 · Cited by 112 · see citing works
Bacterial translocation and changes in the intestinal microbiome associated with alcoholic liver disease
Yan, A. W. (2012) · World Journal of Hepatology · doi:10.4254/wjh.v4.i4.110 · Cited by 110 · see citing works
Portal vein thrombosis in cirrhosis: Controversies and latest developments
Harding, D., Perera, M. T. P. R., Chen, F. E., Olliff, S. P., & Tripathi, D. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i22.6769 · Cited by 110 · see citing works
Hepatic Involvement and Portal Hypertension Predict Mortality in Chronic Granulomatous Disease
Feld, J. J., Hussain, N., Wright, E. C., Kleiner, D. E., Hoofnagle, J. H., Ahlawat, S., Anderson, V., Hilligoss, D. M., Gallin, J. I., Liang, T. J., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.02.081 · Cited by 110 · see citing works
The intestinal microbiome and the leaky gut as therapeutic targets in alcoholic liver disease
Hartmann, P., Chen, W., & Schnabl, B. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00402 · Cited by 109 · see citing works
Gut flora and bacterial translocation in chronic liver disease
Almeida, J. A. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i10.1493 · Cited by 105 · see citing works
Pathogenesis of fibrostenosing Crohn's disease
Li, J., Mao, R., Kurada, S. V., Wang, J., Lin, S., Chandra, J., & Rieder, F. (2019) · Translational research · doi:10.1016/j.trsl.2019.03.005 · Cited by 102 · see citing works
Infectious Complications of Acute and Chronic Liver Disease
Leber, B., Spindelboeck, W., & Stadlbauer, V. (2012) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0032-1301737 · Cited by 103 · see citing works
Plasma Interleukin-6 Levels in Patients with Cirrhosis Relationship to Endotoxemia, Tumor Necrosis Factor-α, and Hyperdynamic Circulation
LEE, F., Lu, R. H., Tsai, Y. T., Lin, H., Hou, M., Li, C. P., Liao, T.-M., LIN, L., Wang, S.-S., & Lee, S. D. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609006772 · Cited by 102 · see citing works
Self-citation
Liver Fibrosis Occurs Through Dysregulation of MyD88-Dependent Innate B-Cell Activity
Thapa, M., Chinnadurai, R., Velazquez, V. M., Tedesco, D., Elrod, E., Han, J., Sharma, P., Ibegbu, C., Gewirtz, A., Anania, F., et al. (2015) · Hepatology · doi:10.1002/hep.27761 · Cited by 101 · see citing works
Bacterial Translocation Up–Regulates Gtp–Cyclohydrolase I in Mesenteric Vasculature of Cirrhotic Rats
Wiest, R., Cadelina, G. W., Milstien, S., McCuskey, R. S., García–Tsao, G., & Groszmann, R. J. (2003) · Hepatology · doi:10.1016/j.hep.2003.09.039 · Cited by 101 · see citing works
Upregulation of TNF-alpha production signaling pathways in monocytes from patients with advanced cirrhosis: Possible role of Akt and IRAK-M
Tazi, K. A., Quioc, J., Saada, V., Bezeaud, A., Lebrec, D., & Moreau, R. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.02.013 · Cited by 99 · see citing works
Epigallocatechin gallate but not catechin prevents nonalcoholic steatohepatitis in mice similar to green tea extract while differentially affecting the gut microbiota
Dey, P., Olmstead, B. D., Sasaki, G. Y., Vodovotz, Y., Yu, Z., & Bruno, R. S. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108455 · Cited by 97 · see citing works
Gut-liver axis and fibrosis in nonalcoholic fatty liver disease: An input for novel therapies
Frăsinariu, O. E., Ceccarelli, S., Alisi, A., Moraru, E., & Nobili, V. (2012) · Digestive and Liver Disease · doi:10.1016/j.dld.2012.11.010 · Cited by 97 · see citing works
Targeting gut-liver axis for the treatment of nonalcoholic steatohepatitis: translational and clinical evidence
Federico, A., Dallio, M., Godos, J., Loguercio, C., & Salomone, F. (2015) · Translational research · doi:10.1016/j.trsl.2015.08.002 · Cited by 96 · see citing works
Profiling of tumour-associated microbiota in human hepatocellular carcinoma
Komiyama, S., Yamada, T., Takemura, N., Kokudo, N., Hase, K., & Kawamura, Y. I. (2021) · Scientific Reports · doi:10.1038/s41598-021-89963-1 · Cited by 96 · see citing works
Thymoquinone alleviates thioacetamide-induced hepatic fibrosis and inflammation by activating LKB1–AMPK signaling pathway in mice
Bai, T., Yang, Y., Wu, Y., Jiang, S., Lee, J. J., Lian, L., & Nan, J. (2014) · International Immunopharmacology · doi:10.1016/j.intimp.2014.02.006 · Cited by 93 · see citing works
Microbiota and gastrointestinal cancer
Weng, M., Chiu, Y., Wei, P., Chiang, C.-W., Fang, H., & Wei, S. (2019) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2019.01.002 · Cited by 90 · see citing works
Chasing a ghost? – Issues with the determination of circulating levels of endotoxin in human blood
Gnauck, A., Lentle, R. G., & Kruger, M. C. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1123215 · Cited by 87 · see citing works
Gut microbial dysbiosis associates hepatocellular carcinoma via the gut-liver axis
Jiang, J., Chen, X., Ren, Z., & Zheng, S. (2018) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2018.11.002 · Cited by 99 · see citing works
The role of the gut microbiome in the development and progression of liver cirrhosis and hepatocellular carcinoma
Roderburg, C., & Luedde, T. (2014) · Gut Microbes · doi:10.4161/gmic.29599 · Cited by 87 · see citing works
Bacterial translocation markers in liver cirrhosis
Alexopoulou, A. A. (2017) · Annals of Gastroenterology · doi:10.20524/aog.2017.0178 · Cited by 87 · see citing works
Toll-Like Receptors in Liver Disease
Petrášek, J., Csák, T., & Szabó, G. (2012) · Advances in clinical chemistry · doi:10.1016/b978-0-12-405211-6.00006-1 · Cited by 85 · see citing works
Effect of chlorogenic acid on LPS-induced proinflammatory signaling in hepatic stellate cells
Shi, H., Dong, L., Dang, X., Liu, Y., Jiang, J., Wang, Y., Lu, X., & Guo, X. (2013) · Inflammation Research · doi:10.1007/s00011-013-0610-7 · Cited by 85 · see citing works
Endotoxin and tumor necrosis factor-receptor levels in portal and hepatic vein of patients with alcoholic liver cirrhosis receiving elective transjugular intrahepatic portosystemic shunt
Trebicka, J., Krag, A. A., Gansweid, S., Appenrodt, B., Schiedermaier, P., Sauerbruch, T., & Spengler, U. (2011) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32834a75dc · Cited by 82 · see citing works
QT Interval Correction in Patients with Cirrhosis
Zambruni, A., Micoli, A. D., Lubisco, A., Domenicali, M., Trevisani, F., & Bernardi, M. (2006) · Journal of Cardiovascular Electrophysiology · doi:10.1111/j.1540-8167.2006.00622.x · Cited by 82 · see citing works
Artesunate alleviates hepatic fibrosis induced by multiple pathogenic factors and inflammation through the inhibition of LPS/TLR4/NF-κB signaling pathway in rats
Lai, L., Chen, Y., Tian, X., Li, X., Zhang, X., Lei, J., Bi, Y., Fang, B., & Song, X. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.08.040 · Cited by 80 · see citing works
The relationship between vitamin C status, the gut-liver axis, and metabolic syndrome
Traber, M. G., Buettner, G. R., & Bruno, R. S. (2018) · Redox Biology · doi:10.1016/j.redox.2018.101091 · Cited by 79 · see citing works
Treatment of endotoxemia
Moore, J. N., & Barton, M. H. (2003) · Veterinary Clinics of North America Equine Practice · doi:10.1016/j.cveq.2003.08.006 · Cited by 78 · see citing works

Authors: Lin, R.-S., Lee, F.-Y., Lee, S.-D., Tsai, Y.-T., Lin, H. C., Rei-Hwa, L., Wan-Ching, H., Cheng-Chun, H., Sun-Sang, W., & Kwang-Juei, L.
Affiliations: Taipei Veterans General Hospital (TW)
National Yang Ming University (TW)
Corresponding author: Lee, Fa-Yauh
ORCID: Lee, Fa-Yauh
Lee, Shou-Dong
Lin, Han Chieh
Venue: Journal of Hepatology
Publisher: Elsevier BV
Published: 1995-02
Volume: 22
Issue: 2
Pages: 165-172
ISSN: 0168-8278 (ISSN-L)
DOI: 10.1016/0168-8278(95)80424-2
OpenAlex: W2155112010
Cited by: 355
References: 40
Citations by year: 2026: 4 · 2025: 10 · 2024: 8 · 2023: 19 · 2022: 15 · 2021: 16 · 2020: 23 · 2019: 16 · 2018: 11 · 2017: 14 · 2016: 16 · 2015: 31 · 2014: 13 · 2013: 14 · 2012: 27
FWCI: 4.26
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Hepatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Keywords: endotoxemia, plasma endotoxin, chronic liver disease, liver cirrhosis, chronic hepatitis, esophageal varices, hyperdynamic circulation, portal hypertension, acute exacerbation, liver dysfunction severity, collateral circulation
MeSH terms: Blood Circulation, Chronic Disease, Endotoxins, Esophageal and Gastric Varices, Female, Hepatitis, Humans, Liver Cirrhosis, Liver Diseases, Male, Middle Aged

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Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophaegeal varices, and hyperdynamic circulation.

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