Cited by 212Liver Disease and TransplantationGut microbiota and healthGastrointestinal motility and disorders

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Small intestinal bacterial overgrowth in human cirrhosis is associated with systemic endotoxemia

Bauer, Tilman M., Schwacha, Henning, Steinbruckner, Bernhard, Brinkmann, Folke E., Ditzen, Anette K., Aponte, John J., Pelz, Klaus, Berger, Dieter, Kist, Manfred, Blum, Hubert E.·2002·The American Journal of Gastroenterology

DOI 10.1111/j.1572-0241.2002.05791.x

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Abstract

OBJECTIVES: Systemic endotoxemia has been implicated in various pathophysiological sequelae of chronic liver disease. One of its potential causes is increased intestinal absorption of endotoxin. We therefore examined the association of small intestinal bacterial overgrowth with systemic endotoxemia in patients with cirrhosis. METHODS: Fifty-three consecutive patients with cirrhosis (Child-Pugh group A, 23; group B, 18; group C, 12) were included. Jejunal secretions were cultivated quantitatively and systemic endotoxemia determined by the chromogenic Limulus amoebocyte assay. Patients were followed up for 1 yr. RESULTS: Small intestinal bacterial overgrowth, defined as > or = 10(5) total colony forming units per milliliter of jejunal secretions, was present in 59% of patients and strongly associated with acid suppressive therapy. The mean plasma endotoxin level was 0.86 +/- 0.48 endotoxin units/ml (range = 0.03-1.44) and was significantly associated with small intestinal bacterial overgrowth (0.99 vs 0.60 endotoxin units/ml, p = 0.03). During the 1-yr follow-up, seven patients were lost to follow up or underwent liver transplantation and 12 patients died. Multivariate Cox regression showed Child-Pugh group to be the only predictor for survival. CONCLUSIONS: Small intestinal bacterial overgrowth in cirrhotic patients is common and associated with systemic endotoxemia. The clinical relevance of this association remains to be defined.

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Hepatogastroenterology
Liu, Y., Zhou, Z., Chen, K.-L., Zhou, B., Yang, L., Yan, H., & Li, Y. (2012) · Hepatogastroenterology · doi:10.5754/hge12281 · Cited by 2,097
Increased intestinal permeability to macromolecules and endotoxemia in patients with chronic alcohol abuse in different stages of alcohol-induced liver disease
Parlesak, A., Schäfer, C., Schütz, T., Bode, J. C., & Bode, C. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80242-1 · Cited by 647
Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess
Bode, C., Kugler, V., & Bode, J. C. (1987) · Journal of Hepatology · doi:10.1016/s0168-8278(87)80003-x · Cited by 529
Increased serum nitrite and nitrate levels in patients with cirrhosis: relationship to endotoxemia
Guarner, C., Soriano, G., Tomas, A., Bulbena, O., Novella, M. T., Balanzo, J., Vilardell, F., Mourelle, M., & Moncada, S. (1993) · Hepatology · doi:10.1002/hep.1840180520 · Cited by 489
Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay
Fukui, H., Brauner, B., Bode, J. C., & Bode, C. (1991) · Journal of Hepatology · doi:10.1016/0168-8278(91)90933-3 · Cited by 461
Endotoxin levels measured by a chromogenic assay in portal, hepatic and peripheral venous blood in patients with cirrhosis
Lumsden, A. B., Henderson, M. J., & Kutner, M. H. (1988) · Hepatology · doi:10.1002/hep.1840080207 · Cited by 427
Endotoxin and Bacteria in Portal Blood
Jacob, A. I., Goldberg, P. K., Bloom, N. D., Degenshein, G. A., & Kozinn, P. J. (1977) · Gastroenterology · doi:10.1016/s0016-5085(77)80025-5 · Cited by 393
Leaky Gut in Alcoholic Cirrhosis: A Possible Mechanism for Alcohol-Induced Liver Damage
Keshavarzian, A., HOLMES, E. W., Patel, M., Iber, F. L., Fields, J. Z., & Pethkar, S. (1999) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.00797.x · Cited by 381
TRIPLET PREGNANCY AFTER PULSATILE ADMINISTRATION OF GONADOTROPIN RELEASING HORMONE
Bogchelman, D. H., Lappöhn, R. E., & Janssens, J. (1982) · The Lancet · doi:10.1016/s0140-6736(82)91180-1 · Cited by 378
Endotoxemia in patients with chronic liver diseases: relationship to severity of liver diseases, presence of esophaegeal varices, and hyperdynamic circulation.
Lin, R.-S., Lee, F.-Y., Lee, S.-D., Tsai, Y.-T., Lin, H. C., Rei-Hwa, L., Wan-Ching, H., Cheng-Chun, H., Sun-Sang, W., & Kwang-Juei, L. (1995) · Journal of Hepatology · doi:10.1016/0168-8278(95)80424-2 · Cited by 355

Show all 43 references

Research works printed but not linked: 10

Bigatello L.M., 1987, Am J Gastroenterol, 82, 11
Kuratsune H., 1983, Hepatogastroenterology, 30, 79
10.1016/S0002-9270(98)00678-9 · DOI
Hoefert B., 1921, Z Klin Med, 92, 221
Chesta J., 1991, Rev Med Chil, 119, 626
Bode C., 1993, Z Gastroenterol, 31, 3
Shindo K., 1993, Am J Gastroenterol, 88, 2084
Chesta J., 1993, Hepatology, 17, 828
Liehr H., 1975, Lancet, 2, 45
Leon-Barua R., 1993, Am J Gastroenterol, 88, 925

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Authors: Bauer, T. M., Schwacha, H., Steinbruckner, B., Brinkmann, F. E., Ditzen, A. K., Aponte, J. J., Pelz, K., Berger, D., Kist, M., & Blum, H. E.
Affiliations: University of Freiburg (DE)
University Medical Center Freiburg (DE)
Hospital Clínic de Barcelona (ES)
University Hospital Ulm (DE)
ORCID: Schwacha, Henning
Brinkmann, Folke E.
Aponte, John J.
Venue: The American Journal of Gastroenterology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2002-09
Volume: 97
Issue: 9
Pages: 2364-2370
ISSN: 0002-9270 (ISSN-L)
1572-0241
DOI: 10.1111/j.1572-0241.2002.05791.x
OpenAlex: W1987665619
Cited by: 211
References: 43
Citations by year: 2026: 5 · 2025: 7 · 2024: 7 · 2023: 13 · 2022: 6 · 2021: 18 · 2020: 12 · 2019: 9 · 2018: 14 · 2017: 13 · 2016: 16 · 2015: 14 · 2014: 12 · 2013: 5 · 2012: 8
FWCI: 2.33
Type: journal article
Language: en
Open access: closed
Locations: The American Journal of Gastroenterology (publishedVersion)
PubMed (publishedVersion)
FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Topics: Health Sciences › Medicine › Hepatology › Liver Disease and Transplantation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords: small intestinal bacterial overgrowth, liver cirrhosis, endotoxin, acid-suppressive therapy, Child-Pugh score, survival, chronic liver disease
MeSH terms: Adult, Aged, Female, Follow-Up Studies, Humans, Jejunum, Liver Cirrhosis, Male, Middle Aged, Predictive Value of Tests, Severity of Illness Index, Time Factors, Colony Count, Microbial, Survival Rate, Endotoxemia

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Small intestinal bacterial overgrowth in human cirrhosis is associated with systemic endotoxemia

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