The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Distinctive Clinical, Psychological, and Histological Features of Postinfective Irritable Bowel Syndrome
Abstract
OBJECTIVE: Irritable bowel syndrome after gastroenteritis is well recognized. Our aim was to determine whether postinfective IBS (PI-IBS) has histological or clinical features that are distinct from those of IBS patients with no history of preceding infection. METHODS: A total of 75 consecutive IBS outpatients and 36 healthy control subjects completed a questionnaire detailing symptoms, mode of onset, and previous psychiatric history. All underwent a full diagnostic workup including rectal biopsy, which included immunostaining and quantification for lamina propria or intraepithelial T lymphocytes, serotonin-containing enterochromaffin (EC), and mast cells. Patients were divided according to onset of symptoms into PI-IBS (n = 23) or non-PI-IBS (n = 52) patients. RESULTS: Diarrhea predominance occurred more frequently in PI-IBS (70%) than in non-PI-IBS (42%) patients (p = 0.03). A history of previous treatment for anxiety or depression was present in 26% of PI-IBS patients compared to 54% of non-PI-IBS (p = 0.02). Biopsy results for all patients were normal using conventional criteria; however, quantification revealed that PI-IBS showed increased EC cells compared to those of non-PI-IBS patients (p = 0.017) and controls (p = 0.02). Lamina propria T lymphocytes were increased in PI-IBS (p = 0.026) and non-PI-IBS (p = 0.011) patients compared to controls. Mast cells were increased in non-PI-IBS patients (p = 0.054) compared to controls. CONCLUSIONS: Individuals with PI-IBS are a clinically distinct subgroup characterized by diarrheal symptoms, less psychiatric illness, and increased serotonin-containing EC cells compared to those with non-PI-IBS.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Other investigators have reported increased gastrointestinal permeability and elevated immune cell counts, even in patients with IBS without an infective aetiology. 54,55”
From Irritable bowel syndrome (2020) · cites this paper as [55]
In the citing paper
“Additionally, increased concentrations of CD3+ T cells in the colon and rectum and in the myenteric plexus of the small intestine were increased in these patients compared with normal controls (36, 46, 57, 58, 89, 94, 133, 168, 174).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [58]
In the citing paper
“However, as with mast cells, IELs are not consistently elevated in IBS patients (57, 58, 133).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [58]
In the citing paper
“However, some studies failed to demonstrate increased activated mast cells in IBS patients (35, 36, 57, 58, 168) and there are no consistent differences in the tissue concentrations of activated mast cells in patients with different IBS subtypes (36, 189).”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [58]
In the citing paper
“The importance of the interaction between the intestinal microbiota and immune system in IBS patients is demonstrated by a few studies in patients with PI-IBS, indicating activation of the GI immune system following the acute GI infection (57, 58, 75, 89, 94, 124, 168, 170, 187)”
From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [58]
In the citing paper
“The evidence from these in vitro studies may shed light on the reported association of stressful life events with the duration of gastroenteritis, and with the subsequent development of postinfectious IBS.37”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [37]
Citations
Cites
The Hospital Anxiety and Depression Scale
Zigmond, A. S., & Snaith, R. P. (1983) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1983.tb09716.x · Cited by 47,139
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155
Self-citationActivation of the mucosal immune system in irritable bowel syndrome
Chadwick, V. S., Chen, W., Shu, D., Paulus, B., Bethwaite, P., Tie, A., & Wilson, I. (2002) · Gastroenterology · doi:10.1053/gast.2002.33579 · Cited by 833
The role of psychological and biological factors in postinfective gut dysfunction
Gwee, K.-A., Leong, Y.-L., Graham, C., McKendrick, M. W., Collins, S. M., Walters, S. J., Underwood, J. E., & Read, N. W. (1999) · Gut · doi:10.1136/gut.44.3.400 · Cited by 764
Neal, K. R., Hebden, J., & Spiller, R. (1997) · BMJ · doi:10.1136/bmj.314.7083.779 · Cited by 586
Self-citationIncreased mast cells in the irritable bowel syndrome
O’Sullivan, Clayton, Breslin, Harman, Bountra, Mclaren, & O’Morain (2000) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2000.00221.x · Cited by 480
Psychometric scores and persistence of irritable bowel after infectious diarrhoea
Gwee, K., Read, N. W., Graham, J. C., McKendrick, M. W., Collins, S. M., Marshall, J. S., & Walters, S. J. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90341-4 · Cited by 466
Role of Serotonin in the Immune System and in Neuroimmune Interactions
Mößner, R., & Lesch, K. (1998) · Brain Behavior and Immunity · doi:10.1006/brbi.1998.0532 · Cited by 434
Psychometric scores and persistence of irritable bowel after infectious diarrhoea
Ka, G., Graham, J. C., McKendrick, M. W., Collins, S. M., Marshall, J. S., Walters, S., & Read, N. W. (1996) · African journal of medical practice · Cited by 429
Research works printed but not linked: 5
- Thompson WG, 1999, Gut, 45, II43
- 10.1016/S0002-9270(98)00751-5 · DOI
- Plaisancie P, 1998, Am J Physiol, 275, G1073
- Frieling T, 1994, Am J Physiol, 266, G132
- Salzmann JL, 1989, Lab Invest, 60, 847
Cited by
Sorted by citations
Items 101–200 of 359
Current insights into the innate immune system dysfunction in irritable bowel syndrome
Lazaridis, N. (2018) · Annals of Gastroenterology · doi:10.20524/aog.2018.0229 · Cited by 77
Törnblom, H., Holmvall, P., Svenungsson, B., & Lindberg, G. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.01.007 · Cited by 70
5‐HT receptors on interstitial cells of Cajal, smooth muscle and enteric nerves
Wouters, M., Farrugia, G., & Schemann, M. (2007) · Neurogastroenterology and Motility · doi:10.1111/j.1365-2982.2007.00963.x · Cited by 74
van Hoboken, E. A., Thijssen, A. Y., Verhaaren, R., van der Veek, P. P. J., Prins, F. A., Verspaget, H. W., & Masclee, A. (2011) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2011.579156 · Cited by 68
“While routine histology does not reveal significantmucosal abnormalities, quantitativehistology and immunohistochemistry point to subtlemorphologic changes in IBS [4–8].”
BackgroundSpiller, R. E. (2004) · British Medical Bulletin · doi:10.1093/bmb/ldh039 · Cited by 68
Self-citationSubjects with Diarrhea-Predominant IBS Have Increased Rectal Permeability Responsive to Tryptase
Lee, J. W., Park, J., Park, D., Park, J., Kim, H., Cho, Y., Sohn, C., Jeon, W., & Kim, B. I. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-1094-8 · Cited by 63
“Diarrhea-predominant IBS (D-IBS) without an infectious onset was associated with an increase in lamina propria mast cells and T lymphocytes [2, 22].”
BackgroundGuagnozzi, D., Arias, Á., & Lucendo, A. J. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13573 · Cited by 68
“of MC after finding an increase in the colonic serotoninpositive cell density, which probably results from the interaction between lymphocytes and enterochromaffin cells.(70) Serotonin is known to accelerate intestinal motil-”
BackgroundChemotactic Chemokines Are Important in the Pathogenesis of Irritable Bowel Syndrome
Darkoh, C., Comer, L., Zewdie, G., Harold, S. A., Snyder, N., & DuPont, H. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093144 · Cited by 67
“PI-IBS was defined as patients who meet the Rome II criteria with the onset of their chronic intestinal problem preceded by a bout of acute diarrhea or gastroenteritis [15].”
MethodIntestinal Permeability in Irritable Bowel Syndrome Patients: Effects of NSAIDs
Kerckhoffs, A., Akkermans, L., de Smet, M. D., Besselink, M. G., Hietbrink, F., Bartelink, I., Busschers, W., Samsom, M., & Renooij, W. (2010) · Digestive Diseases and Sciences · doi:10.1007/s10620-009-0765-9 · Cited by 69
“The number of mast cells that infiltrate inflamed tissue is increased in large intestinal mucosa of IBS patients [3, 41–43].”
BackgroundIs irritable bowel syndrome an inflammatory disorder?
De Giorgio, R., & Barbara, G. (2008) · Current Gastroenterology Reports · doi:10.1007/s11894-008-0073-0 · Cited by 64
The Chronic Gastrointestinal Consequences Associated With Campylobacter
Riddle, M. S., Gutiérrez, R. L., Verdu, E. F., & Porter, C. K. (2012) · Current Gastroenterology Reports · doi:10.1007/s11894-012-0278-0 · Cited by 65
Post-Infectious Irritable Bowel Syndrome
Lee, Y. Y., Chandramouli, A., & Rao, S. S. C. (2017) · Current Gastroenterology Reports · doi:10.1007/s11894-017-0595-4 · Cited by 67
Chronic Stress, Inflammation, and Colon Cancer: A CRH System-Driven Molecular Crosstalk
Baritaki, S., de Bree, E., Chatzaki, Ε., & Pothoulakis, C. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8101669 · Cited by 67
“B and T cell populations, the specific cells of adaptive immunity, are mainly found in the intestinal mucosa [116].”
Post‐inflammatory modification of colonic afferent mechanosensitivity
Hughes, P. A., Brierley, S. M., & Blackshaw, L. A. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05248.x · Cited by 62
“may be increased in biopsies from patients with unclassified IBS, but this correlation is weaker when applied specifically to the PI-IBS patient cohort.(21,22,24) Enterochromaffin cells and some populations of mast cells release serotonin,(25,26) an important neuromodulator with potent actions on gastrointestinal phys…”
BackgroundPost-infection Irritable Bowel Syndrome
Berumen, A., Edwinson, A. L., & Grover, M. (2021) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2021.02.007 · Cited by 54
Ahn, J. Y., Lee, K. H., Choi, C. H., Kim, J. W., Lee, H. W., Kim, J. W., Kim, M. K., Kwon, G. Y., Han, S., Kim, S., et al. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2930-4 · Cited by 59
Postinflammatory visceral sensitivity and pain mechanisms
Vergnolle, N. (2008) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2008.01110.x · Cited by 60
Donnachie, E., Schneider, A., Mehring, M., & Enck, P. (2018) · Gut · doi:10.1136/gutjnl-2017-313713 · Cited by 74
Bengtsson, M., Hammar, O., Mandl, T., & Ohlsson, B. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-122 · Cited by 57
“Immunological mechanisms seem to be more dominant in post-infectious IBS, and may be a separate entity of the disease [37-39].”
BackgroundLeifeld, L., Germer, C., Böhm, S. K., Dumoulin, F. L., Frieling, T., Kreis, M. E., Meining, A. G., Labenz, J., Lock, J. F., Ritz, J., et al. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1741-5724 · Cited by 60
Verdu, E. F., & Riddle, M. S. (2012) · The American Journal of Gastroenterology · doi:10.1038/ajg.2012.65 · Cited by 56
Ouyang, A., & Wrzos, H. F. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00975.x · Cited by 57
“Subsequent studies confirm the greater prevalence of these psychological traits, but the female gender appeared to be less of a risk factor (51).”
BackgroundHistopathological alterations in irritable bowel syndrome
Kirsch, R., & Riddell, R. H. (2006) · Modern Pathology · doi:10.1038/modpathol.3800704 · Cited by 57
Keating, C. D., Pelegrı́n, P., Martínez, C. M., & Grundy, D. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100423 · Cited by 56
“rise to chronic abdominal symptoms, including pain (1).”
BackgroundSystematic review: prevention of travellers’ diarrhoea
DuPont, H. L. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03647.x · Cited by 55
Mearin, F., Juan, A. P., Balboa, A., Perona, M. C., Sans, M., Salas, A., Angulo, S., Lloreta, J., Benasayag, R., García-González, M. A., et al. (2009) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520903171276 · Cited by 55
5-HT system in the gut: roles in the regulation of visceral sensitivity and motor functions.
Grundy, D. (2008) · PubMed · Cited by 55
Kraneveld, A. D., Rijnierse, A., Nijkamp, F. P., & Garssen, J. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.095 · Cited by 57
“Although irritable bowel syndrome is mainly correlated with an unchanged mucosal structure, low grade infiltration of inflammatory cells can be observed (Dunlop et al., 2003) which can progress into a chronic inflammatory condition especially when irritable bowel syndrome is manifested after infection (Quigley, 2005).”
BackgroundEscalante, J., Artaiz, O., Diwakarla, S., & McQuade, R. M. (2024) · GeroScience · doi:10.1007/s11357-024-01451-2 · Cited by 62
Mechanisms in IBS: something old, something new, something borrowed…
Camilleri, M. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2004.00632.x · Cited by 54
Arebi, N., Gurmany, S., Bullas, D. C., Hobson, A. R., Stagg, A. J., & Kamm, M. A. (2008) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2008.03801.x · Cited by 53
Using human intestinal biopsies to study the pathogenesis of irritable bowel syndrome
Nasser, Y., Boeckxstaens, G. E., Wouters, M. M., Schemann, M., & Vanner, S. J. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12316 · Cited by 53
Motility Abnormalities in Irritable Bowel Syndrome
Dupont, A. W., Jiang, Z., Harold, S. A., Snyder, N., Galler, G. W., Garcia-Torres, F., & DuPont, H. L. (2014) · Digestion · doi:10.1159/000356314 · Cited by 52
Irritable pouch syndrome is characterized by visceral hypersensitivity
Shen, B., Sanmiguel, C. P., Bennett, A. E., Lian, L., Larive, B., Remzi, F. H., Fazio, V. W., & Soffer, E. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21412 · Cited by 52
Ishihara, S., Tada, Y., Fukuba, N., Oka, A., Kusunoki, R., Mishima, Y., Oshima, N., Moriyama, I., Yuki, T., Kawashima, K., et al. (2013) · Digestion · doi:10.1159/000350054 · Cited by 51
Abnormal rectal endocrine cells in patients with irritable bowel syndrome
El‐Salhy, M., Gundersen, D., Hatlebakk, J. G., Gilja, O. H., & Hausken, T. (2013) · Regulatory Peptides · doi:10.1016/j.regpep.2013.11.005 · Cited by 52
Postinfection Irritable Bowel Syndrome
Downs, I. A., Aroniadis, O. C., Kelly, L., & Brandt, L. J. (2017) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000924 · Cited by 56
Infection, immune function, and functional gut disorders
Spiller, R. E. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00159-4 · Cited by 52
Self-citationThe Clinical Course of Postinfectious Irritable Bowel Syndrome
Jung, I. S., Kim, H. S., Park, H., & Lee, S. I. (2009) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31818c87d7 · Cited by 51
“Age (y), median (range) 31 (25-39) 37 (30-51) 32 (28-57)”
Chatoo, M., Li, Y., Ma, Z., Coote, J. H., Du, J.-Z., & Chen, X. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00021 · Cited by 50
“The immune cells are mainly found in the intestinal mucosa (67).”
BackgroundOn the fiftieth anniversary Postinfectious irritable bowel syndrome: mechanisms related to pathogens
Grover, M., Camilleri, M., Smith, K., Linden, D. R., & Farrugia, G. (2014) · Neurogastroenterology & Motility · doi:10.1111/nmo.12304 · Cited by 48
Gastrointestinal symptoms in COVID-19: the long and the short of it
Freedberg, D. E., & Chang, L. (2022) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000876 · Cited by 51
Increased serum free tryptophan in patients with diarrhea-predominant irritable bowel syndrome
Christmas, D. M., Badawy, A. A. ‐., Hince, D., Davies, S., Probert, C. S., Creed, T., Smithson, J., Afzal, M., Nutt, D., & Potokar, J. P. (2010) · Nutrition Research · doi:10.1016/j.nutres.2010.09.009 · Cited by 48
“In addition, some subsets of IBS sufferers have higher numbers of enterochromaffin cells [27], emphasizing the potential pathologic role of 5-HT in IBS.”
BackgroundPersistent Abdominal Symptoms in US Adults After Short‐Term Stay in Mexico
Nair, P., Okhuysen, P. C., Jiang, Z., Carlin, L. G., Belkind‐Gerson, J., Flores, J., Paredes, M., & DuPont, H. L. (2014) · Journal of Travel Medicine · doi:10.1111/jtm.12114 · Cited by 46
Camilleri, M. (2011) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.2011.261 · Cited by 47
Epidemiology: prevalence, causes and consequences
Creed, F. H., BARSKY, A. J., & Leiknes, K. A. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511977862.002 · Cited by 48
The development of irritable bowel syndrome: a prospective community-based cohort study
Löwe, B., Lohse, A., Andresen, V., Vettorazzi, E., Rose, M., & Broicher, W. (2016) · American Journal of Gastroenterology · doi:10.1038/ajg.2016.255 · Cited by 43
The role of the gastrointestinal barrier in obesity‐associated systemic inflammation
Acciarino, A., Diwakarla, S., Handreck, J., Bergola, C., Sahakian, L., & McQuade, R. M. (2023) · Obesity Reviews · doi:10.1111/obr.13673 · Cited by 55
“62 66 Striking neuronal changes including lymphocytic infiltration of the myenteric plexus and neuronal degeneration have also been noted in full thickness jejunal specimens from severe IBS patients.”
BackgroundSerotonin, Inflammation, and IBS: Fitting the Jigsaw Together?
Spiller, R. E. (2007) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31812e66da · Cited by 44
“Weston 1993, IBS-D (22) T ileum O’Sullivan 2000, IBS-D (23) Caecum Gwee 1999, PI-IBS (16) Rectum Spiller 2000, PI-IBS (17) Rectum Chadwick 2003, IBS-D (24) Colon Dunlop 2003, IBS-D (not PI-IBS) (25) Rectum Dunlop 2003, PI-IBS (10) Rectum Wang 2004, PI-IBS & IBS-D (11) T ileum”
Self-citationNakov, R., Dimitrova‐Yurukova, D., Snegarova, V., Nakov, V., Fox, M. R., & Heinrich, H. S. (2021) · Neurogastroenterology & Motility · doi:10.1111/nmo.14197 · Cited by 47
Mullin, G. E., Shepherd, S. J., Roland, B. C., Ireton-Jones, C. S., & Matarese, L. E. (2014) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607114545329 · Cited by 47
Mast Cells in Irritable Bowel Syndrome: A Systematic Review
Krammer, L., Sowa, A. S., & Lorentz, A. (2019) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld-229 · Cited by 45
Tuteja, A. K., Fang, J. C., Al-Suqi, M., Stoddard, G. J., & Hale, D. C. (2012) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2012.694903 · Cited by 41
“It occurs in 7–33% of patients following acute gastroenteritis and is usually diarrhea-predominant [4-6].”
BackgroundInfluentialInflammation as a cause of functional bowel disorders
Törnblom, H., Abrahamsson, H., Barbara, G., Hellström, P. M., Lindberg, G., Nyhlin, H., Ohlsson, B., Simrén, M., Sjölund, K., Sjövall, H., et al. (2005) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520510023657 · Cited by 42
Microbial Origins of Chronic Diseases
Gargano, L. M., & Hughes, J. M. (2013) · Annual Review of Public Health · doi:10.1146/annurev-publhealth-032013-182426 · Cited by 42
Extrinsic Sensory Afferent Nerves Innervating the Gastrointestinal Tract
Beyak, M. J., Bulmer, D. C., Jiang, W. G., Keating, C., Rong, W., & Grundy, D. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50028-3 · Cited by 41
Lalani, T., Maguire, J. D., Grant, E. M., Fraser, J., Ganesan, A., Johnson, M. D., Deiss, R., Riddle, M. S., Burgess, T. H., Tribble, D. R., et al. (2014) · Journal of Travel Medicine · doi:10.1111/jtm.12179 · Cited by 40
“Moderate or severe TD 78 (12) 6 (26) 0.”
BackgroundGut microbiota and sirtuins in obesity-related inflammation and bowel dysfunction
Lakhan, S. E., & Kirchgessner, A. L. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-202 · Cited by 41
“Furthermore, alterations in gut function were observed even after the resolution of an acute intestinal inflammation [97-99].”
BackgroundIrritable bowel syndrome: recent developments in diagnosis, pathophysiology, and treatment
El‐Salhy, M., Hatlebakk, J. G., Gilja, O. H., & Hausken, T. (2014) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2014.888952 · Cited by 39
Laing, S. T., Merriam, D., Shock, B. C., Mills, S., Spinner, A., Reader, J. R., & Hartigan-O’Connor, D. J. (2018) · Veterinary Pathology · doi:10.1177/0300985818780449 · Cited by 39
Post-infectious irritable bowel syndrome
Rhodes, D. Y., & Wallace, M. R. (2006) · Current Gastroenterology Reports · doi:10.1007/s11894-006-0054-0 · Cited by 39
“group characterized by more diarrheal symptoms, less prevalence of psychiatric illness, and increased serotonincontaining enterochromaffin cells [ 37 ].”
BackgroundResultIrritable bowel syndrome immune hypothesis: the role of lymphocytes and mast cells
Lucas, M. O., Peiró, P. S., & Domingo, J. J. S. (2010) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082010001100004 · Cited by 38
Schmulson, M. J., Bielsa, M. V., Carmona-Sánchez, R., Hernández, A., López‐Colombo, A., López‐Vidal, Y., Peláez‐Luna, M., Remes-Troche, J. M., Tamayo, J. L., & Valdovinos, M. A. (2014) · Revista de Gastroenterología de México (English Edition) · doi:10.1016/j.rgmxen.2014.01.001 · Cited by 38
Liu, S., Shi, Q., Zhu, Q., Zou, T., Li, G., Huang, A., Wu, B., Peng, L., Song, M., Wu, Q., et al. (2014) · Purinergic Signalling · doi:10.1007/s11302-014-9439-y · Cited by 36
“IBS and inflammatory bowel disease often exhibit visceral hypersensitivity [1–3].”
BackgroundBlackett, J. W., Sun, Y., Purpura, L. J., Margolis, K. G., Elkind, M. S. V., O’Byrne, S. M., Wainberg, M. L., Abrams, J. A., Wang, H. H., Chang, L., et al. (2022) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000524 · Cited by 36
Wang, Y. M., Ge, X. Z., Wang, W. Q., Wang, T., Cao, H., Wang, B. L., & Wang, B. M. (2015) · Neurogastroenterology & Motility · doi:10.1111/nmo.12615 · Cited by 35
Fjorback, L. O., Carstensen, T. B. W., Arendt, M. C. B. B., Ørnbøl, E., Walach, H., Rehfeld, E., & Fink, P. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2012.09.010 · Cited by 35
“In theNetherlands,medically unexplained symptoms and somatoformdisorders is the fifth most expensive diagnostic category [10,11].”
BackgroundBoyer, J., Saint‐Paul, M., Dadone‐Montaudié, B., Patouraux, S., Vivinus, M., Ouvrier, D., Michiels, J., Piche, T., & Tulić, M. K. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13223 · Cited by 35
Bolino, C., & Berčík, P. (2010) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2010.07.005 · Cited by 34
Role of environmental pollution in irritable bowel syndrome
Marynowski, M. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i40.11371 · Cited by 34
A pilot study of colonic B cell pattern in irritable bowel syndrome
Forshammar, J., Isaksson, S., Strid, H., Stotzer, P.-O., Sjövall, H., Simrén, M., & Öhman, L. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802272126 · Cited by 33
Reduced chromogranin A cell density in the ileum of patients with irritable bowel syndrome
El‐Salhy, M., WENDELBO, I. H., & Gundersen, D. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1325 · Cited by 33
Postinfectious Irritable Bowel Syndrome: A Long-Term Consequence of Bacterial Gastroenteritis
Smith, J. L., & Bayles, D. O. (2007) · Journal of Food Protection · doi:10.4315/0362-028x-70.7.1762 · Cited by 33
“(23) found that patients with IBS, both PI-IBS and non-PI-IBS, had a higher likelihood of a history of treatment for anxiety or depression compared with controls without IBS; however, significantly fewer patients with PI-IBS had a history of treatment for anxiety or de-”
BackgroundRoka, R., Ait-Belgnaoui, A., Salvador‐Cartier, C., Garcia-Villar, R., Fioramonti, J., Eutamène, H., & Bueno, L. (2007) · Gut · doi:10.1136/gut.2006.115352 · Cited by 39
Wang, S. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.13.6041 · Cited by 32
Protease activated receptor 4 status of mast cells in post infectious irritable bowel syndrome
Han, W., Zhimin, W. A. N. G., Lu, X. F., & Guo, C. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01841.x · Cited by 32
Post-infectious irritable bowel syndrome
Dupont, A. W. (2007) · Current Gastroenterology Reports · doi:10.1007/s11894-007-0046-8 · Cited by 32
Role of gut pathogens in development of irritable bowel syndrome.
Grover, M. (2014) · Europe PMC (PubMed Central) · Cited by 31
Overlap between Irritable Bowel Syndrome and Inflammatory Bowel Disease
Spiller, R. E. (2009) · Digestive Diseases · doi:10.1159/000268121 · Cited by 31
“This study showed the increases in lymphocytes to be distributed throughout the colon, though in this study, unlike most others, mast cells were not increased. When we studied IBS patients with diarrhoea without an infectious origin, we also found increased numbers of mast cells and CD3 lymphocytes in the rectum [”
ResultSelf-citationGastrointestinal infections and the development of irritable bowel syndrome
DuPont, H. L. (2011) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32834a962d · Cited by 33
Postinfectious Functional Gastrointestinal Disorders
Mearin, F. (2011) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31821fbf58 · Cited by 30
Pimentel, M., & Chang, C. C.-C. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.010 · Cited by 30
Microbiome, antibiotics and irritable bowel syndrome
Ahmad, O. F., & Akbar, A. (2016) · British Medical Bulletin · doi:10.1093/bmb/ldw038 · Cited by 29
Effects of probiotic supplementation on post-infectious irritable bowel syndrome in rodent model
Hong, K., Seo, H.-Y., Lee, J.-S., & Park, Y. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2610-9 · Cited by 29
Schmulson, M., Bielsa, M. V., Carmona-Sánchez, R., Hernández, A., López-Colombo, A., López Vidal, Y., Peláez-Luna, M., Remes-Troche, J. M., Tamayo, J. L., & Valdovinos, M. A. (2014) · Revista de Gastroenterología de México · doi:10.1016/j.rgmx.2014.01.004 · Cited by 29
Postinfectious Chronic Gut Dysfunction: From Bench to Bedside
Collins, S. M., Chang, C. C.-C., & Mearin, F. (2012) · The American Journal of Gastroenterology Supplements · doi:10.1038/ajgsup.2012.2 · Cited by 28
Barbara, G., Stanghellini, V., Cremon, C., GIORGIO, R. D., & Corinaldesi, R. (2007) · Digestive Diseases · doi:10.1159/000103894 · Cited by 28
“Basically, a hyperplasia of enterochromaffin cells and an increase in post-prandial serotonin have been shown in rectal biopsies of patients 3 weeks after acute infection [”
BackgroundChoudhury, B. K., Shi, X.-Z. P., & Sarna, S. K. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90673.2008 · Cited by 28
“Most patients with PI-IBS, however, are diarrhea predominant (13).”
BackgroundPsychometric scores and persistence of irritable bowel afterCampylobacter concisusinfection
Nielsen, H. L., Engberg, J., Ejlertsen, T., & Nielsen, H. V. (2014) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2014.886718 · Cited by 27
Neural mechanisms of early postinflammatory dysmotility in rat small intestine
Demedts, I., Geboes, K. J., Kindt, S., Berghe, P. V., Andrioli, A., Janssens, J., & Tack, J. F. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00857.x · Cited by 27
Bafutto, M., de Almeida, J. R. D., Leite, N. V., Oliveira, Ê., Gabriel-Neto, S., & Rezende-filho, J. (2011) · Arquivos de Gastroenterologia · doi:10.1590/s0004-28032011000100008 · Cited by 28
“Individuals with PI-IBS are a clinically distinct subgroup characterized by diarrheal symptoms, less psychiatric illness, and increased serotonin-containing EC compared to those with non-PI-IBS(8).”
BackgroundAminosalicylates and Other Anti-Inflammatory Compounds for Irritable Bowel Syndrome
Barbara, G., Stanghellini, V., Cremon, C., GIORGIO, R. D., Fronzoni, L., Serra, M., & Corinaldesi, R. (2009) · Digestive Diseases · doi:10.1159/000268131 · Cited by 27
“Although most studies have reported increased immune cells in mucosal biopsies obtained from the rectum [”
BackgroundCurrent and future developments in travelers’ diarrhea therapy
Koo, H. L., & DuPont, H. L. (2006) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.4.3.417 · Cited by 26
Kalia, N., Hardcastle, J., Keating, C., Pelegrı́n, P., Grundy, D., Grasa, L., & Bardhan, K. D. (2007) · Gut · doi:10.1136/gut.2006.118356 · Cited by 26
Hons, I. M., Burda, J. E., Grider, J. R., Mawe, G. M., & Sharkey, K. A. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90472.2008 · Cited by 26
“Abnormalities in function also occur during periods of remission from IBD, when there is resolution of inflammation (14, 27, 55).”
BackgroundProtozoan parasites in irritable bowel syndrome: A case-control study
Jadallah, K. A., Nimri, L. F., & Ghanem, R. A. (2017) · World Journal of Gastrointestinal Pharmacology and Therapeutics · doi:10.4292/wjgpt.v8.i4.201 · Cited by 25
Tikoo, S., Barki, N., Jain, R., Zulkhernain, N. S., Bühner, S., Schemann, M., & Weninger, W. (2018) · Immunological Reviews · doi:10.1111/imr.12631 · Cited by 25
Systematic Review and Meta-analysis: Efficacy of Mesalamine in Irritable Bowel Syndrome
Goodoory, V. C., Tuteja, A. K., Black, C. J., & Ford, A. C. (2023) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2023.02.014 · Cited by 30
Choi, K., Chen, J., MITRA, S. P., & Sarna, S. K. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.074 · Cited by 25
Nakane, S., Mukaino, A., Ihara, E., & Ogawa, Y. (2020) · Immunological Medicine · doi:10.1080/25785826.2020.1797319 · Cited by 24
“In patients with post-infectious irritable bowel syndrome, quantitative histology showed evidence of continuing inflammation, with elevated intra-epithelial T cell levels in rectal biopsy [53,54].”
Background
Metadata
- Authors
- Dunlop, S. P., Jenkins, D., & Spiller, R. C.
- Affiliations
- Nottingham University Hospitals NHS Trust (GB)
- ORCID
- Jenkins, David
- Venue
- American Journal of Gastroenterology
- Published
- 2003-07
- Volume
- 98
- Issue
- 7
- Pages
- 1578-1583
- ISSN
- 0002-9270 (ISSN-L)
- OpenAlex
- W2033889517
- Cited by
- 359
- References
- 32
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 10 · 2019: 9 · 2018: 14 · 2017: 13 · 2016: 17 · 2015: 14 · 2014: 28 · 2013: 24 · 2012: 23
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- irritable bowel syndrome, gastroenteritis, rectal biopsy, enterochromaffin cells, serotonin, mast cells, diarrhea, psychiatric comorbidity, anxiety, depression, immunohistochemistry
- MeSH terms
- Adult, Mental Disorders, Biopsy, Cell Count, Colonic Diseases, Functional, Diarrhea, Enterochromaffin Cells, Female, Gastroenteritis, Humans, Immunohistochemistry, Male, Mast Cells, Middle Aged, Rectum, Serotonin, T-Lymphocytes
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
