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Cited by 85Gastrointestinal motility and disordersInflammatory Bowel DiseaseMicroscopic Colitis

Increased Immunoendocrine Cells in Intestinal Mucosa of Postinfectious Irritable Bowel Syndrome Patients 3 Years after Acute Shigella Infection - An Observation in a Small Case Control Study

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Kim, Hee Sun, Lim, Jung Hyun, Park, Hyojin, Lee, Sang In·2010·Yonsei Medical Journal
DOI 10.3349/ymj.2010.51.1.45PMC PMC2799963
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Abstract

PURPOSE: Postinfectiously irritable bowel syndrome (PI-IBS) develops in 3-30% of individuals with bacterial gastroenteritis. Recent studies demonstrated increases in inflammatory components in gut mucosa of PI-IBS patients even after complete resolution of infection. We aimed to investigate histological changes in colon and rectum of PI-IBS subjects after long term period of infection. MATERIALS AND METHODS: We recruited PI-IBS subjects who had been diagnosed IBS after complete resolution of enteritis caused by shigellosis outbreak 3 years earlier. We compared unmatched four groups, PI-IBS (n = 4), non PI-IBS (n = 7), D-IBS (n = 7, diarrhea predominant type) and healthy controls (n = 10). All of them underwent colonoscopic biopsy at three areas, including descending colon (DC), sigmoid colon (SC) and rectum, which were assessed for 5-hydroxytryptamine (5-HT)/peptide YY (PYY)-containing enterochromaffin (EC) cell, intraepithelial (IEL) and lamina propria T lymphocyte (CD3), CD8 lymphocytes, mast cells and CD68/calprotectin+ macrophages. RESULTS: All subjects had no structural or gross abnormalities at colonoscopy. In PI-IBS, 5-HT containing EC cells, PYY containing EC cells, IELs, CD3 lymphocytes, CD8 lymphocytes, mast cells, and CD68 + macrophages were increased compared to control (p < 0.05). In D-IBS, PYY containing EC cells, IELs, and CD3 lymphocytes were increased compared to control (p < 0.05). In PI-IBS, 5-HT containing EC cells tended to increase and PYY containing EC cells, CD8 lymphocytes, mast cells, and CD68+ macrophages were increased compared to non PI-IBS (p < 0.05). Calprotectin + marcrophages were decreased in PI-IBS, non PI-IBS and IBS compared to control. CONCLUSION: The immunoendocrine cells were sporadically increased in PI-IBS, non PI-IBS and D-IBS compared with control. Our findings in a very small number of patients suggest that mucosal inflammation may play a role in long-term PI-IBS, and that other sub-groups of IBS and larger scale studies are needed to confirm this observation.

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  • Increased concentrations of CD3+ T cells in the colon and rectum and in the myenteric plexus of the small intestine were increased in patients with IBS or PI-IBS compared with normal controls.

    “Additionally, increased concentrations of CD3+ T cells in the colon and rectum and in the myenteric plexus of the small intestine were increased in these patients compared with normal controls (36, 46, 57, 58, 89, 94, 133, 168, 174).”

    From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [89]

  • Some studies demonstrated an increase in activated mast cells in biopsies from specific regions of the GI tract (cecum and terminal ileum) but not from other regions, whereas other studies found activated mast cells in the descending colon.

    “Notably, some studies demonstrated an increase in activated mast cells in biopsies from specific regions of the GI tract (i.e., cecum and terminal ileum) but not from other regions (e.g., ascending colon, descending colon, rectum) (89, 121, 187), whereas other studies have found activated mast cells in the descending colon (11, 13).”

    From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [89]

  • Several studies have demonstrated increased concentrations of activated mast cells in patients with IBS compared with controls.

    “Several studies have demonstrated increased concentrations of activated mast cells in patients with IBS compared with controls (11, 13, 24, 46, 89, 94, 121, 187).”

    From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [89]

  • Concentrations of intestinal epithelial lymphocytes may be increased in the small intestine, colon, and rectum of patients with IBS or PI-IBS.

    “The concentrations of intestinal epithelial lymphocytes (IELs) may be increased in the small intestine (73, 174, 185), colon, and rectum (36, 89) of patients with IBS or PI-IBS.”

    From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [89]

  • Concentrations of cytotoxic CD8+ T cells may be elevated in the lamina propria of the colon of patients with IBS or PI-IBS, although this finding was disputed by others.

    “Concentrations of cytotoxic CD8+ T cells, which comprise most of the intraepithelial T cell population (126) may also be elevated in the lamina propria of the colon of patients with IBS (46, 123) or PI-IBS (89) although this finding was disputed by others (36).”

    From Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome (2013) · cites this paper as [89]

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Research works printed but not linked: 1

  1. [39]Chadwick VS Chen W Shu D Paulus B Bethwait P Tie A Activation of the mucosal immune system in irritable bowel syndrome Gastroenterology 2002 122 1778 1783 12055584

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Authors
Kim, H. S., Lim, J. H., Park, H., & Lee, S. I.
Affiliations
Yonsei University (KR)
Corresponding author
Park, Hyojin
ORCID
Venue
Yonsei Medical Journal
Publisher
XMLink
Published
2010
Volume
51
Issue
1
Pages
45
ISSN
0513-5796 (ISSN-L)
DOI
10.3349/ymj.2010.51.1.45
PMC
PMC2799963
OpenAlex
W2134456599
Cited by
85
References
40
Citations by year
2025: 2 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 6 · 2018: 5 · 2017: 2 · 2016: 7 · 2015: 7 · 2014: 18 · 2013: 9 · 2012: 9
FWCI
5.32
Type
journal article
Language
en
Open access
Licence
Locations
  • Yonsei Medical Journal (publishedVersion, cc-by-nc)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Epidemiology › Microscopic Colitis
Keywords
post-infectious irritable bowel syndrome, shigellosis, enterochromaffin cells, serotonin, peptide YY, intraepithelial lymphocytes, lamina propria lymphocytes, mast cells, macrophages, calprotectin, colonic mucosa, diarrhea-predominant irritable bowel syndrome
MeSH terms
CD68 Molecule, Adult, Colonoscopy, Dysentery, Bacillary, Enterochromaffin Cells, Female, Humans, Immunohistochemistry, Intestinal Mucosa, Macrophages, Male, Mast Cells, Rectum, Serotonin, Colon, Sigmoid, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Case-Control Studies, CD8-Positive T-Lymphocytes, Peptide YY, Irritable Bowel Syndrome, Colon, Descending

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