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Cited by 208Gut microbiota and healthInflammatory Bowel DiseaseMicroscopic Colitis

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Unstable Composition of the Fecal Microbiota in Ulcerative Colitis During Clinical Remission

Martinez, Cristina, Antolin, Maria, Santos, Javier, Torrejon, Antonio, Casellas, Francesc, Borruel, Natalia, Guarner, Francisco, Malagelada, Juan-R.·2008·The American Journal of Gastroenterology
DOI 10.1111/j.1572-0241.2007.01592.x
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Abstract

BACKGROUND AND AIM: Studies have identified abnormal characteristics of the gut microbiota in patients with active IBD, but whether the changes are causal or secondary to inflammation remains uncertain. We investigated dynamics of fecal microbiota in ulcerative colitis (UC) during remission by genomic technology. PATIENTS AND METHODS: Patients in clinical remission and on stable maintenance mesalazine therapy were recruited (N = 33). Fecal samples were collected at regular intervals over a period of 1 yr. Sixteen patients who remained in remission and eight healthy controls were included in the analysis. Variable V6 to V8 regions of the 16S rRNA gene in DNA extracts from fecal samples were amplified by polymerase chain reaction. Amplicons were separated by denaturant gradient gel electrophoresis, band profiles were compared by software, and similarity indices were calculated from densitometric curves. RESULTS: Band profiles showed unique patterns with low similarity index between individuals, suggesting host specificity in the predominant microbiota. Within the same individual, profiles were stable in controls but varied notably over time in patients. In controls, the similarity index was remarkably stable (78 +/- 8% mean +/- SD) over a period of 24 months. However, patients showed a steady decline in similarity index versus the initial profile, dropping down to 42 +/- 24% at month 3 of follow-up and to 23 +/- 19% at month 12 (P < 0.001). Biodiversity of the dominant microbiota, as estimated by number of bands, was lower in patients (17 +/- 4) than controls (23 +/- 4, P < 0.01). CONCLUSION: Molecular analysis of fecal bacteria in patients with inactive UC shows low biodiversity and temporal instability.

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Crossref · 10.1111/j.1572-0241.2007.01592.x

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Metadata

Authors
Martinez, C., Antolin, M., Santos, J., Torrejon, A., Casellas, F., Borruel, N., Guarner, F., & Malagelada, J.-R.
Affiliations
  • Vall d'Hebron Hospital Universitari (ES)
  • Instituto de Salud Carlos III (ES)
ORCID
Venue
The American Journal of Gastroenterology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2008-03
Volume
103
Issue
3
Pages
643-648
ISSN
  • 0002-9270 (ISSN-L)
  • 1572-0241
DOI
10.1111/j.1572-0241.2007.01592.x
OpenAlex
W1967499190
Cited by
208
References
25
Citations by year
2026: 3 · 2025: 5 · 2024: 12 · 2023: 5 · 2022: 12 · 2021: 14 · 2020: 17 · 2019: 9 · 2018: 17 · 2017: 12 · 2016: 19 · 2015: 11 · 2014: 18 · 2013: 14 · 2012: 10
FWCI
4.11
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of Gastroenterology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Generalitat de Catalunya
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
  • Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
Keywords
ulcerative colitis, fecal microbiota, clinical remission, microbial diversity, temporal stability, 16S rRNA gene, 5-aminosalicylic acid, inflammatory bowel disease, host specificity, microbiota dynamics
MeSH terms
Adult, Colitis, Ulcerative, DNA, Bacterial, Electrophoresis, Polyacrylamide Gel, Feces, Female, Humans, Male, Middle Aged, Remission Induction, Polymerase Chain Reaction, DNA Fingerprinting

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