Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease

Ott, S J; Musfeldt, M; Wenderoth, D F; Hampe, J; Brant, O; Fölsch, U R; Timmis, K N; Schreiber, S

doi:10.1136/gut.2003.025403

Cited by 1,311Gut microbiota and healthInflammatory Bowel DiseaseOral microbiology and periodontitis research

Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease

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Ott, S J, Musfeldt, M, Wenderoth, D F, Hampe, J, Brant, O, Fölsch, U R, Timmis, K N, Schreiber, S·2004·Gut

DOI 10.1136/gut.2003.025403PMC PMC1774050

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Abstract

Background and aims: The intestinal bacterial microflora plays an important role in the aetiology of inflammatory bowel disease (IBD). As most of the colonic bacteria cannot be identified by culture techniques, genomic technology can be used for analysis of the composition of the microflora. Patients and methods: The mucosa associated colonic microflora of 57 patients with active inflammatory bowel disease and 46 controls was investigated using 16S rDNA based single strand conformation polymorphism (SSCP) fingerprint, cloning experiments, and real time polymerase chain reaction (PCR). Results: Full length sequencing of 1019 clones from 16S rDNA libraries (n = 3) revealed an overall bacterial diversity of 83 non-redundant sequences—among them, only 49 known bacterial species. Molecular epidemiology of the composition of the colonic microflora was investigated by SSCP. Diversity of the microflora in Crohn’s disease was reduced to 50% compared with controls (21.7 v 50.4; p<0.0001) and to 30% in ulcerative colitis (17.2 v 50.4; p<0.0001). The reduction in diversity in inflammatory bowel disease was due to loss of normal anaerobic bacteria such as Bacteroides species, Eubacterium species, and Lactobacillus species, as revealed by direct sequencing of variable bands and confirmed by real time PCR. Bacterial diversity in the Crohn’s group showed no association with CARD15/NOD2 status. Conclusions: Mucosal inflammation in inflammatory bowel disease is associated with loss of normal anaerobic bacteria. This effect is independent of NOD2/CARD15 status of patients.

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IBD is associated with decreased complexity in composition, with a loss of normal anaerobic bacteria, temporary composition instability during clinical remission, and dysbiosis towards selected microorganisms, with over- and under-representation of certain species.
“There is a decreased complexity in composition, with a loss of normal anaerobic bacteria [33] , a temporary composition instability during clinical remission [34] , and a dysbiosis towards selected microorganisms, with over-and under-representation of certain species [35] .”
From Intestinal microbiota in health and disease: Role of bifidobacteria in gut homeostasis (2014) · cites this paper as [33]

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Origins and Directions of Inflammatory Bowel Disease, Early Studies of the “Nonspecific” Inflammatory Bowel Diseases
Levine, J. S. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)70023-7 · Cited by 6 · see citing works

Authors: Ott, S. J., Musfeldt, M., Wenderoth, D. F., Hampe, J., Brant, O., Fölsch, U. R., Timmis, K. N., & Schreiber, S.
Affiliations: University Hospital Schleswig-Holstein (DE)
Helmholtz Centre for Infection Research (DE)
Corresponding author: Schreiber, S
ORCID: Ott, S J
Hampe, J
Timmis, K N
Venue: Gut
Publisher: BMJ
Published: 2004-04-13
Volume: 53
Issue: 5
Pages: 685-693
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.2003.025403
PMC: PMC1774050
OpenAlex: W2121187468
Cited by: 1,311
References: 91
Citations by year: 2026: 21 · 2025: 49 · 2024: 73 · 2023: 89 · 2022: 107 · 2021: 107 · 2020: 68 · 2019: 89 · 2018: 71 · 2017: 68 · 2016: 64 · 2015: 63 · 2014: 65 · 2013: 53 · 2012: 46
FWCI: 12.08
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Crohn's and Colitis Foundation of America
Crohn's and Colitis Foundation
Deutsche Forschungsgemeinschaft (SFB 415)
Bundesministerium für Bildung und Forschung
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: inflammatory bowel disease, colonic mucosa, bacterial diversity, Crohn's disease, ulcerative colitis, anaerobic bacteria, Bacteroides, Eubacterium, Lactobacillus, NOD2/CARD15, mucosal inflammation, 16S rRNA gene
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Bacteria, Bacteria, Anaerobic, Carrier Proteins, Colon, Crohn Disease, Female, Genotype, Humans, Intestinal Mucosa, Male, Middle Aged, Phylogeny, RNA, Ribosomal, 16S, Inflammatory Bowel Diseases, Gene Library, Polymerase Chain Reaction, Polymorphism, Single-Stranded Conformational, Intracellular Signaling Peptides and Proteins, Nod2 Signaling Adaptor Protein

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Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease

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