Cited by 208Gut microbiota and healthInflammatory Bowel DiseaseMicroscopic Colitis

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Unstable Composition of the Fecal Microbiota in Ulcerative Colitis During Clinical Remission

Martinez, Cristina, Antolin, Maria, Santos, Javier, Torrejon, Antonio, Casellas, Francesc, Borruel, Natalia, Guarner, Francisco, Malagelada, Juan-R.·2008·The American Journal of Gastroenterology

DOI 10.1111/j.1572-0241.2007.01592.x

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Abstract

BACKGROUND AND AIM: Studies have identified abnormal characteristics of the gut microbiota in patients with active IBD, but whether the changes are causal or secondary to inflammation remains uncertain. We investigated dynamics of fecal microbiota in ulcerative colitis (UC) during remission by genomic technology. PATIENTS AND METHODS: Patients in clinical remission and on stable maintenance mesalazine therapy were recruited (N = 33). Fecal samples were collected at regular intervals over a period of 1 yr. Sixteen patients who remained in remission and eight healthy controls were included in the analysis. Variable V6 to V8 regions of the 16S rRNA gene in DNA extracts from fecal samples were amplified by polymerase chain reaction. Amplicons were separated by denaturant gradient gel electrophoresis, band profiles were compared by software, and similarity indices were calculated from densitometric curves. RESULTS: Band profiles showed unique patterns with low similarity index between individuals, suggesting host specificity in the predominant microbiota. Within the same individual, profiles were stable in controls but varied notably over time in patients. In controls, the similarity index was remarkably stable (78 +/- 8% mean +/- SD) over a period of 24 months. However, patients showed a steady decline in similarity index versus the initial profile, dropping down to 42 +/- 24% at month 3 of follow-up and to 23 +/- 19% at month 12 (P < 0.001). Biodiversity of the dominant microbiota, as estimated by number of bands, was lower in patients (17 +/- 4) than controls (23 +/- 4, P < 0.01). CONCLUSION: Molecular analysis of fecal bacteria in patients with inactive UC shows low biodiversity and temporal instability.

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Authors: Martinez, C., Antolin, M., Santos, J., Torrejon, A., Casellas, F., Borruel, N., Guarner, F., & Malagelada, J.-R.
Affiliations: Vall d'Hebron Hospital Universitari (ES)
Instituto de Salud Carlos III (ES)
ORCID: Santos, Javier
Casellas, Francesc
Borruel, Natalia
Guarner, Francisco
Venue: The American Journal of Gastroenterology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2008-03
Volume: 103
Issue: 3
Pages: 643-648
ISSN: 0002-9270 (ISSN-L)
1572-0241
DOI: 10.1111/j.1572-0241.2007.01592.x
OpenAlex: W1967499190
Cited by: 208
References: 25
Citations by year: 2026: 3 · 2025: 5 · 2024: 12 · 2023: 5 · 2022: 12 · 2021: 14 · 2020: 17 · 2019: 9 · 2018: 17 · 2017: 12 · 2016: 19 · 2015: 11 · 2014: 18 · 2013: 14 · 2012: 10
FWCI: 4.11
Type: journal article
Language: en
Open access: closed
Locations: The American Journal of Gastroenterology (publishedVersion)
PubMed (publishedVersion)
Funders: Generalitat de Catalunya
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Health Sciences › Medicine › Gastroenterology › Microscopic Colitis
Keywords: ulcerative colitis, fecal microbiota, clinical remission, microbial diversity, temporal stability, 16S rRNA gene, 5-aminosalicylic acid, inflammatory bowel disease, host specificity, microbiota dynamics
MeSH terms: Adult, Colitis, Ulcerative, DNA, Bacterial, Electrophoresis, Polyacrylamide Gel, Feces, Female, Humans, Male, Middle Aged, Remission Induction, Polymerase Chain Reaction, DNA Fingerprinting

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Unstable Composition of the Fecal Microbiota in Ulcerative Colitis During Clinical Remission

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