The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Rising Prevalence of Venous Thromboembolism and Its Impact on Mortality Among Hospitalized Inflammatory Bowel Disease Patients
Abstract
BACKGROUND: We sought to determine nationwide, population-based trends in rates of venous thromboembolism (VTE) among hospitalized inflammatory bowel disease (IBD) patients in the United States and to determine its mortality and economic impact. METHODS: We analyzed discharges from the Nationwide Inpatient Sample and used ICD-9-CM codes to identify Crohn's disease (CD) and ulcerative colitis (UC) between 1998 and 2004. Rates of VTE were compared between those with and without IBD. The impact of VTE on in-hospital mortality and resource utilization was quantified using regression analysis. RESULTS: After multivariate adjustment, both UC (OR 1.85, 95% CI 1.70-2.01) and CD discharges (OR 1.48, 95% CI 1.35-1.62) had higher rates of VTE compared to non-IBD discharges. Prevalence of VTE was greater among UC compared to CD discharges (OR 1.32, 95% CI 1.17-1.48). Among CD patients, active fistulizing disease was independently associated with greater VTE (OR 1.39, 95% CI 1.13-1.70). There was an annual 17% rise in odds of VTE among IBD admissions over 7 yr. VTE was associated with greater mortality among IBD patients (adjusted OR 2.50, 95% CI 1.83-3.43). This age- and comorbidity-adjusted excess mortality from VTE was 2.1-fold higher for IBD than for non-IBD patients (P < 0.0001). IBD patients with VTE had longer length of stay (11.7 vs 6.1 days, P < 0.0001) and incurred higher hospital charges ($47,515 vs $21,499; P < 0.0001). CONCLUSIONS: VTE is increasingly prevalent among hospitalized IBD patients and has substantial mortality and economic impact. These findings drive the need for widespread prophylaxis against and early detection of VTE among IBD inpatients.
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Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data
Quan, H., Sundararajan, V., Halfon, P., Fong, A., Burnand, B., Luthi, J.-C., Saunders, L. D., Beck, C. A., Feasby, T. E., & Ghali, W. A. (2005) · Medical Care · doi:10.1097/01.mlr.0000182534.19832.83 · Cited by 10,669
Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases
DEYO, R. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90133-8 · Cited by 10,452
Bias and causal associations in observational research
Grimes, D. A., & Schulz, K. F. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07451-2 · Cited by 1,553
Guidelines for the management of inflammatory bowel disease in adults
Carter, M. J., Lobo, A. J., & Travis, S. P. L. (2004) · Gut · doi:10.1136/gut.2004.043372 · Cited by 1,083
Vascular Complications of Inflammatory Bowel Disease
TALBOT, R. W., HEPPELL, J., DOZOIS, R. R., & BEART, R. W. (1986) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)65200-8 · Cited by 630
Validity of Information on Comorbidity Derived From ICD-9-CCM Administrative Data
Quan, H., Parsons, G. A., & Ghali, W. A. (2002) · Medical Care · doi:10.1097/00005650-200208000-00007 · Cited by 579
Blanchard, J., Houston, D., Wajda, A., & Bernstein, C. (2001) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1615600 · Cited by 577
Is inflammatory bowel disease an independent and disease specific risk factor for thromboembolism?
Miehsler, W., Reinisch, W., Valic, E., Osterode, W., Tillinger, W., Feichtenschlager, T., Grisar, J., Machold, K., Scholz, S., Vogelsang, H., et al. (2004) · Gut · doi:10.1136/gut.2003.025411 · Cited by 479
Inflammation and Coagulation in Inflammatory Bowel Disease: The Clot Thickens
Danese, S., Papa, A., Saibeni, S., Repici, A., Malesci, A., & Vecchi, M. (2007) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00943.x · Cited by 384
Cited by
Lamb, C. A., Kennedy, N. A., Raine, T., Hendy, P. A., Smith, P. J., Limdi, J. K., Hayee, B., Lomer, M. C. E., Parkes, G. C., Selinger, C., et al. (2019) · Gut · doi:10.1136/gutjnl-2019-318484 · Cited by 2,346
Magro, F., Gionchetti, P., Eliakim, R., Ardizzone, S., Armuzzi, A., Barreiro-de Acosta, M., Burisch, J., Gecse, K. B., Hart, A. L., Hindryckx, P., et al. (2017) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjx008 · Cited by 1,910
Van Assche, G., Dignass, A., Reinisch, W., van der Woude, C. J., Sturm, A., De Vos, M., Guslandi, M., Oldenburg, B., Dotan, I., Marteau, P., et al. (2010) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2009.09.009 · Cited by 894
Grainge, M. J., West, J., & Card, T. R. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61963-2 · Cited by 730
Epidemiology and prevention of venous thromboembolism
Lutsey, P. L., & Zakai, N. A. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00787-6 · Cited by 507
Metadata
- Authors
- Nguyen, G. C., & Sam, J.
- Venue
- The American Journal of Gastroenterology
- Published
- 2008-09
- Volume
- 103
- Issue
- 9
- Pages
- 2272-2280
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2062219046
- Cited by
- 364
- References
- 21
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- closed
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