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Potential prophylactic value of bovine colostrum in necrotizing enterocolitis in neonates: an in vitro study on bacterial attachment, antibody levels and cytokine production
Open accessAbstract
Necrotizing enterocolitis (NEC) is an important disease of low birth-weight neonates. The immaturity of the gut mucosa may result in close contact between the host epithelium and microorganisms which are normally confined to the gut lumen. Damage of the mucosa due to endotoxin, cytokine production or other factors is believed to then occur. The aim of this study was to determine whether spray-dried bovine colostrum demonstrated potential in vitro as a prophylactic for NEC. Antiadherence was measured using a tissue culture assay and antibody levels against Enterobacteriaceae were determined by ELISA. The effect of bovine colostrum on the production of cytokines implicated in NEC was determined by a multiplex bead assay. Enterobacter cloacae, Klebsiella oxytoca, Escherichia coli, Serratia marcescens and Klebsiella pneumoniae ssp. pneumoniae were common in both NEC positive and NEC negative infants and IgA and IgG1 antibodies to these species were present in the bovine colostrum. Pretreatment with bovine colostrum produced a significant decrease (P<0.001) in attachment of bacteria to HT-29 cells. Bovine colostrum significantly increased the production of IL-8 in HT-29 cells and IL-8, IL-6 and TNF-alpha in THP-1 cells (P<0.001). The potential of bovine colostrum to increase the production of inflammatory mediators could limit its usefulness.
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Bovine colostrum contains immune proteins that can modulate the immune system.
“While bovine colostrum not only contains a limited amount of milk oligosaccharides that may promote the growth of this particular bacteria [35, 36], it also contains an abundance of immune proteins, including immunoglobulins, lactoferrin and a range of cytokines, that can further modulate the microbiota [40] and the immune system [40–42].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [40]
Bovine colostrum contains immune proteins that can modulate the microbiota.
“While bovine colostrum not only contains a limited amount of milk oligosaccharides that may promote the growth of this particular bacteria [35, 36], it also contains an abundance of immune proteins, including immunoglobulins, lactoferrin and a range of cytokines, that can further modulate the microbiota [40] and the immune system [40–42].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [40]
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Sanctuary, M. R., Kain, J. N., Chen, S. Y., Kalanetra, K., Lemay, D. G., Rose, D. R., Yang, H. T., Tancredi, D. J., German, J. B., Slupsky, C. M., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0210064 · Cited by 255
Playford, R. J. (2024) · Nutrients · doi:10.3390/nu16213684 · Cited by 4
Metadata
- Authors
- Brooks, H. J. L., McConnell, M. A., Corbett, J., Buchan, G. S., Fitzpatrick, C. E., & Broadbent, R. S.
- Affiliations
- University of Otago (NZ)
- Corresponding author
- Brooks, Heather J.L.
- Venue
- FEMS Immunology & Medical Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2006-12
- Volume
- 48
- Issue
- 3
- Pages
- 347-354
- ISSN
- 0928-8244 (ISSN-L)
- 1574-695X
- OpenAlex
- W2054564157
- Cited by
- 33
- References
- 35
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2019: 3 · 2018: 1 · 2016: 2 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Immunology & Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Otago
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Neonatal and Maternal Infections
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal health and immunology
- Keywords
- necrotizing enterocolitis, bovine colostrum, prophylaxis, low birth weight infants, bacterial adhesion, Enterobacteriaceae, IgA antibodies, IgG1 antibodies, cytokine production, interleukin-8, interleukin-6, TNF-α, intestinal mucosa, HT-29 cells, THP-1 cells
- MeSH terms
- Animals, Bacterial Adhesion, Cattle, Cells, Cultured, Colostrum, Enterobacteriaceae, Enterobacteriaceae Infections, Feces, Humans, Immunoglobulin A, Immunoglobulin G, Infant, Low Birth Weight, Infant, Newborn, Cytokines, Enterocolitis, Necrotizing, Premature Birth
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