The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Tracing isolates of bacterial species by multilocus variable number of tandem repeat analysis (MLVA)
Open accessAbstract
All bacterial genomes contain multiple loci of repetitive DNA. Repeat unit sizes and repeat sequences may vary when multiple loci are considered for different isolates of an individual microbial species. Moreover, it has been documented on many occasions that the number of repeat units per locus is a strain-defining parameter. Consequently, there is isolate-specificity in the number of repeats per locus when different strains of a given bacterial species are compared. The experimental assessment of this variability for a number of different loci has been called 'multilocus variable number of tandem repeat analysis' (MLVA). The approach can be supported or extended by locus-specific DNA sequencing for establishing mutations in the individual repeat units, which usually enhances the resolution of the approach considerably. Essentially, MLVA with or without supportive sequencing has been developed for all of the medically relevant bacterial species and can be used effectively for tracing outbreaks or other forms of bacterial dissemination. MLVA is a modern, timely and versatile bacterial typing methodology.
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“Distributions of TRs in the genomic loci are also recognized as the variable number of TR regions that have been widely used to determine an individual's inherited traits as well as for molecular typing both in prokaryotic and eukaryotic species.61”
From Whole genomic DNA sequencing and comparative genomic analysis of Arthrospira platensis: high genome plasticity and genetic diversity (2016) · cites this paper as [61]
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Whole-Genome Random Sequencing and Assembly of Haemophilus influenzae Rd
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Identification of genes that are associated with DNA repeats in prokaryotes
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Investigation of Bioterrorism-Related Anthrax, United States, 2001: Epidemiologic Findings
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“These regions have been used for subtyping bacteria (Lindstedt et al. , 2004; Torpdahl et al. , 2006; van Belkum, 2007).”
Metadata
- Authors
- Van Belkum, A.
- Venue
- FEMS Immunology & Medical Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-02
- Volume
- 49
- Issue
- 1
- Pages
- 22-27
- ISSN
- 0928-8244 (ISSN-L)
- 1574-695X
- OpenAlex
- W2085293610
- Cited by
- 203
- References
- 66
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 4 · 2022: 3 · 2021: 1 · 2020: 8 · 2019: 9 · 2018: 8 · 2017: 11 · 2016: 11 · 2015: 14 · 2014: 19 · 2013: 18 · 2012: 14
- FWCI
- 1.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEMS Immunology & Medical Microbiology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Health Sciences › Medicine › Microbiology (medical) › Bacterial Identification and Susceptibility Testing
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- MLVA, strain typing, bacterial genotyping, repetitive DNA, outbreak source tracing, bacterial dissemination
- MeSH terms
- Bacillus anthracis, Bacteria, DNA, Bacterial, Humans, Mycobacterium tuberculosis, Staphylococcus aureus, Genome, Bacterial, Minisatellite Repeats, Bioterrorism
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