Cited by 203Bacterial Identification and Susceptibility TestingAntimicrobial Resistance in StaphylococcusGenetic diversity and population structure

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Tracing isolates of bacterial species by multilocus variable number of tandem repeat analysis (MLVA)

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Van Belkum, Alex·2007·FEMS Immunology & Medical Microbiology

DOI 10.1111/j.1574-695x.2006.00173.x

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Abstract

All bacterial genomes contain multiple loci of repetitive DNA. Repeat unit sizes and repeat sequences may vary when multiple loci are considered for different isolates of an individual microbial species. Moreover, it has been documented on many occasions that the number of repeat units per locus is a strain-defining parameter. Consequently, there is isolate-specificity in the number of repeats per locus when different strains of a given bacterial species are compared. The experimental assessment of this variability for a number of different loci has been called 'multilocus variable number of tandem repeat analysis' (MLVA). The approach can be supported or extended by locus-specific DNA sequencing for establishing mutations in the individual repeat units, which usually enhances the resolution of the approach considerably. Essentially, MLVA with or without supportive sequencing has been developed for all of the medically relevant bacterial species and can be used effectively for tracing outbreaks or other forms of bacterial dissemination. MLVA is a modern, timely and versatile bacterial typing methodology.

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“1486 011809 G 2009 SGM Printed in Great Britain Downloaded from www.microbiologyresearch.org by IP: 54.70.40.11 On: Wed, 07 Nov 2018 16:58:56 molecular typing method that has been applied to several bacterial pathogens, including S. sonnei (Liang et al., 2007; van Belkum, 2007).”
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“In contrast, MultiLocus Variable number of tandem repeat Analysis (MLVA) has been shown to allow revealing infraspecific genetic diversity in several human monomorphic pathogens (Van Belkum, 2007; Lindstedt, 2005; Pourcel & Vergnaud, 2011).”
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Background
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Authors: Van Belkum, A.
Venue: FEMS Immunology & Medical Microbiology
Publisher: Oxford University Press (OUP)
Published: 2007-02
Volume: 49
Issue: 1
Pages: 22-27
ISSN: 0928-8244 (ISSN-L)
1574-695X
DOI: 10.1111/j.1574-695x.2006.00173.x
OpenAlex: W2085293610
Cited by: 203
References: 66
Citations by year: 2026: 1 · 2025: 8 · 2024: 4 · 2022: 3 · 2021: 1 · 2020: 8 · 2019: 9 · 2018: 8 · 2017: 11 · 2016: 11 · 2015: 14 · 2014: 19 · 2013: 18 · 2012: 14
FWCI: 1.43
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: FEMS Immunology & Medical Microbiology (publishedVersion)
PubMed (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
Topics: Health Sciences › Medicine › Microbiology (medical) › Bacterial Identification and Susceptibility Testing
Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
Keywords: MLVA, strain typing, bacterial genotyping, repetitive DNA, outbreak source tracing, bacterial dissemination
MeSH terms: Bacillus anthracis, Bacteria, DNA, Bacterial, Humans, Mycobacterium tuberculosis, Staphylococcus aureus, Genome, Bacterial, Minisatellite Repeats, Bioterrorism

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Tracing isolates of bacterial species by multilocus variable number of tandem repeat analysis (MLVA)

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