The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Virulence strategies of the dominant USA300 lineage of community-associated methicillin-resistant Staphylococcus aureus(CA-MRSA)
Open accessAbstract
Methicillin-resistant Staphylococcus aureus (MRSA) poses a serious threat to worldwide health. Historically, MRSA clones have strictly been associated with hospital settings, and most hospital-associated MRSA (HA-MRSA) disease resulted from a limited number of virulent clones. Recently, MRSA has spread into the community causing disease in otherwise healthy people with no discernible contact with healthcare environments. These community-associated MRSA clones (CA-MRSA) are phylogenetically distinct from traditional HA-MRSA clones, and CA-MRSA strains seem to exhibit hypervirulence and more efficient host : host transmission. Consequently, CA-MRSA clones belonging to the USA300 lineage have become dominant sources of MRSA infections in North America. The rise of this successful USA300 lineage represents an important step in the evolution of emerging pathogens and a great deal of effort has been exerted to understand how these clones evolved. Here, we review much of the recent literature aimed at illuminating the source of USA300 success and broadly categorize these findings into three main categories: newly acquired virulence genes, altered expression of common virulence determinants and alterations in protein sequence that increase fitness. We argue that none of these evolutionary events alone account for the success of USA300, but rather their combination may be responsible for the rise and spread of CA-MRSA.
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Cites
Klevens, R. M. (2007) · JAMA · doi:10.1001/jama.298.15.1763 · Cited by 3,726 · cited 2×
“aureus can lead to aggressive and often fatal necrotizing pneumonia (Francis et al., 2005; Hageman et al., 2006; Klevens et al., 2007).”
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Methicillin-Resistant S. aureus Infections among Patients in the Emergency Department
Moran, G. J., Krishnadasan, A., Gorwitz, R. J., Fosheim, G. E., McDougal, L. K., Carey, R. B., & Talan, D. A. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055356 · Cited by 2,285
Gillet, Y., Issartel, B., Vanhems, P., Fournet, J.-C., Lina, G., Bes, M., Vandenesch, F., Piémont, Y., Brousse, N., Floret, D., et al. (2002) · The Lancet · doi:10.1016/s0140-6736(02)07877-7 · Cited by 1,514
Miller, L. G., Perdreau-Remington, F., Rieg, G., Mehdi, S., Perlroth, J., Bayer, A. S., Tang, A. W., Phung, T. O., & Spellberg, B. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa042683 · Cited by 1,053
Wang, R., Braughton, K. R., Kretschmer, D., Bach, T.-H. L., Queck, S. Y., Li, M., Kennedy, A. D., Dorward, D. W., Klebanoff, S. J., Peschel, A., et al. (2007) · Nature Medicine · doi:10.1038/nm1656 · Cited by 1,046
Poring over pores: α-hemolysin and Panton-Valentine leukocidin in Staphylococcus aureus pneumonia
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Basis of Virulence in Community-Associated Methicillin-Resistant Staphylococcus aureus
Otto, M. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134309 · Cited by 457
Evolution of virulence in epidemic community-associated methicillin-resistant Staphylococcus aureus
Li, M., Diep, B. A., Villaruz, A. E., Braughton, K. R., Jiang, X., DeLeo, F. R., Chambers, H. F., Lu, Y., & Otto, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900743106 · Cited by 394 · cited 3×
“Furthermore, USA300 strains were more lethal in septic infections compared with archaic and Iberian clones as well as ST239 clones (Brazilian clones) (Li et al., 2009).”
BackgroundInfluentialDiep, B. A., Chan, L., Tattevin, P., Kajikawa, O., Martin, T. R., Basuino, L., Mai, T. T., Marbach, H., Braughton, K. R., Whitney, A. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912403107 · Cited by 347
Cited by
Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology
Lakhundi, S., & Zhang, K. (2018) · Clinical Microbiology Reviews · doi:10.1128/cmr.00020-18 · Cited by 1,637
The Bicomponent Pore-Forming Leucocidins of Staphylococcus aureus
Alonzo, F., & Torres, V. J. (2014) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00055-13 · Cited by 276
CodY, a master integrator of metabolism and virulence in Gram-positive bacteria
Brinsmade, S. R. (2017) · Current Genetics · doi:10.1007/s00294-016-0656-5 · Cited by 89
Nutritional regulation of the Sae two-component system by CodY in Staphylococcus aureus
Mlynek, K. D., Sause, W. E., Moormeier, D. E., Sadykov, M. R., Hill, K. R., Torres, V. J., Bayles, K. W., & Brinsmade, S. R. (2018) · Journal of Bacteriology · doi:10.1128/jb.00012-18 · Cited by 41
Gillard, K., Miller, H. B., & Blackledge, M. S. (2018) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13361 · Cited by 20
Metadata
- Authors
- Thurlow, L. R., Joshi, G. S., & Richardson, A. R.
- Venue
- FEMS Immunology & Medical Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-06
- Volume
- 65
- Issue
- 1
- Pages
- 5-22
- ISSN
- 0928-8244 (ISSN-L)
- 1574-695X
- OpenAlex
- W2006840128
- Cited by
- 166
- References
- 19
- FWCI
- 8.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Thurlow, L. R., Joshi, G. S., & Richardson, A. R. (2012). Virulence strategies of the dominant USA300 lineage of community-associated methicillin-resistant Staphylococcus aureus(CA-MRSA). FEMS Immunology & Medical Microbiology. https://doi.org/10.1111/j.1574-695x.2012.00937.x
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