Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene
Abstract
The nucleotide sequence analysis of the dihydropteroate synthase (DHPS) gene of six diaminodiphenylsulfone-resistant Mycobacterium leprae strains revealed that the mutation was limited at highly conserved amino acid residues 53 or 55. Though the mutation at amino acid residue 55 or its homologous site has been reported in other bacteria, the mutation at residue 53 is the first case in bacteria. This is the first paper which links the mutations in DHPS and sulfonamide resistance in M. leprae. This finding is medically and socially relevant, since leprosy is still a big problem in certain regions.
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Similar point mutations in positions equivalent to this site in Plasmodium falciparum and Mycobacterium leprae confer sulfa resistance.
“Likewise, similar point mutations in positions equivalent to this site in Plasmodium falciparum (15) and Mycobacterium leprae (28) confer sulfa resistance.”
From Dihydropteroate Synthase Gene Mutations in<i>Pneumocystis</i>and Sulfa Resistance (2004) · cites this paper as [28]
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Dihydropteroate Synthase Gene Mutations in<i>Pneumocystis</i>and Sulfa Resistance
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“Likewise, similar point mutations in positions equivalent to this site in Plasmodium falciparum (15) and Mycobacterium leprae (28) confer sulfa resistance.”
Background
- Authors
- Kai, M., Matsuoka, M., Nakata, N., Maeda, S., Gidoh, M., Maeda, Y., Hashimoto, K., Kobayashi, K., & Kashiwabara, Y.
- Affiliations
- National Institute of Infectious Diseases (JP)
- Corresponding author
- Kai, Masanori
- Venue
- FEMS Microbiology Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-08
- Volume
- 177
- Issue
- 2
- Pages
- 231-235
- ISSN
- 0378-1097 (ISSN-L)
- 1574-6968
- OpenAlex
- W1976863414
- Cited by
- 81
- References
- 19
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 3 · 2012: 9
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEMS Microbiology Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Kanazawa University
- Topics
- Health Sciences › Medicine › Infectious Diseases › Leprosy Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
- Keywords
- Mycobacterium leprae, dapsone, sulfonamide resistance, dihydropteroate synthase, leprosy, drug resistance
- MeSH terms
- Dapsone, Dihydropteroate Synthase, Drug Resistance, Microbial, Folic Acid Antagonists, Genes, Bacterial, Leprostatic Agents, Leprosy, Molecular Sequence Data, Mutation, Mycobacterium leprae
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