The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Triclosan: a widely used biocide and its link to antibiotics
Open accessAbstract
Triclosan is the active ingredient in a multitude of health care and consumer products with germicidal properties, which have flooded the market in recent years in response to the public's fear of communicable bacteria. Although originally thought to kill bacteria by attacking multiple cellular targets, triclosan was recently shown to target a specific bacterial fatty acid biosynthetic enzyme, enoyl-[acyl-carrier protein] reductase, in Gram-negative and Gram-positive bacteria, as well as in the Mycobacteria. Triclosan resistance mechanisms include target mutations, increased target expression, active efflux from the cell, and enzymatic inactivation/degradation. These are the same types of mechanisms involved in antibiotic resistance and some of them account for the observed cross-resistance with antibiotics in laboratory isolates. Therefore, there is a link between triclosan and antibiotics, and the widespread use of triclosan-containing antiseptics and disinfectants may indeed aid in development of microbial resistance, in particular cross-resistance to antibiotics.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Antiseptics and Disinfectants: Activity, Action, and Resistance
McDonnell, G., & Russell, A. D. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.1.147 · Cited by 4,780
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen
Stover, C. K., Pham, X. Q., Erwin, A. L., Mizoguchi, S. D., Warrener, P., Hickey, M. J., Brinkman, F. S. L., Hufnagle, W. O., Kowalik, D. J., Lagrou, M., et al. (2000) · Nature · doi:10.1038/35023079 · Cited by 4,573
Triclosan targets lipid synthesis
McMurry, L. M., Oethinger, M., & Levy, S. B. (1998) · Nature · doi:10.1038/28970 · Cited by 1,019
Molecular Properties of Bacterial Multidrug Transporters
Putman, M., van Veen, H. W., & Konings, W. N. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.4.672-693.2000 · Cited by 795
Identification of genes controlled by quorum sensing in Pseudomonas aeruginosa
Whiteley, M., Lee, K. M., & Greenberg, E. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.13904 · Cited by 650
Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa
Li, X. Z., Nikaido, H., & Poole, K. (1995) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.39.9.1948 · Cited by 643
Ko¨hler, T., Michéa‐Hamzehpour, M., Henze, U., Gotoh, N., Kocjancic Curty, L., & Pechère, J. (1997) · Molecular Microbiology · doi:10.1046/j.1365-2958.1997.2281594.x · Cited by 549
Mechanism of Triclosan Inhibition of Bacterial Fatty Acid Synthesis
Heath, R. J., Rubin, J. R., Holland, D. R., Zhang, E., Snow, M. E., & Rock, C. O. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.11110 · Cited by 542
Triclosan: Applications and safety
Bhargava, H. N., & Leonard, P. A. (1996) · American Journal of Infection Control · doi:10.1016/s0196-6553(96)90017-6 · Cited by 529
Triclosan: A review of effectiveness and safety in health care settings
Jones, R. D., Jampani, H. B., Newman, J. L., & Lee, A. S. (2000) · American Journal of Infection Control · doi:10.1016/s0196-6553(00)90027-0 · Cited by 487
Cited by
Efflux-mediated antimicrobial resistance
Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082
Triclosan: environmental exposure, toxicity and mechanisms of action
Dann, A. B., & Hontela, A. (2011) · Journal of Applied Toxicology · doi:10.1002/jat.1660 · Cited by 868
Russell, A. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00833-8 · Cited by 419
Cosmetics preservation: a review on present strategies
Halla, N., Fernandes, I. P., Heleno, S. A., Costa, P., Boucherit-Otmani, Z., Boucherit, K., Rodrigues, A. E., Ferreira, I. C. F. R., & Barreiro, M. F. (2018) · Molecules · doi:10.3390/molecules23071571 · Cited by 401
Action of Disinfectant Quaternary Ammonium Compounds against Staphylococcus aureus
Ioannou, C. J., Hanlon, G. W., & Denyer, S. P. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00375-06 · Cited by 377
Metadata
- Authors
- Schweizer, H.
- Venue
- FEMS Microbiology Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 2001-08-07
- Volume
- 202
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0378-1097 (ISSN-L)
- OpenAlex
- W2127879973
- Cited by
- 447
- References
- 34
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Triclosan: a widely used biocide and its link to antibiotics. https://app.cochat.ai/papers/10.1016/s0378-1097(01)00273-7
- The paper
- Schweizer, H. (2001). Triclosan: a widely used biocide and its link to antibiotics. FEMS Microbiology Letters. https://doi.org/10.1016/s0378-1097(01)00273-7
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
