The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The role of quorum sensing in chronic cystic fibrosis Pseudomonas aeruginosa infections
Abstract
Studies on cultured cells and in infection models have shown that cell density-dependent quorum-sensing (QS) controls many of the known virulence factors of Pseudomonas aeruginosa. However, it is less clear what role QS plays in chronic human lung infections associated with cystic fibrosis (CF). The involvement of QS in biofilm development, crucial to the establishment of long-term infections, suggests a role in the early stages of infection. However, the accumulation of QS mutants during chronic CF infections has been taken to indicate that any role diminishes thereafter. Here, we discuss the evidence for a continuing role for QS in P. aeruginosa CF infections, including QS activity in CF sputa and CF-relevant effects of QS-regulated products, such as pyocyanin. Bacterial population behaviour in CF is complex, and the exact roles of QS remains unclear. Therapeutic strategies directed against QS suggest that a greater understanding of bacterial populations during infection would be a valuable research goal from a clinical perspective.
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Cites
Analysis of quorum sensing-deficient clinical isolates of Pseudomonas aeruginosa
Schaber, J. A., Carty, N. L., McDonald, N. A., Graham, E. D., Cheluvappa, R., Griswold, J. A., & Hamood, A. N. (2004) · Journal of Medical Microbiology · doi:10.1099/jmm.0.45617-0 · Cited by 224
Cited by
Pseudomonas aeruginosa : new insights into pathogenesis and host defenses
Gellatly, S. L., & Hancock, R. E. W. (2013) · Pathogens and Disease · doi:10.1111/2049-632x.12033 · Cited by 1,295
Pierson, L. S., & Pierson, E. A. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2509-3 · Cited by 560
Clinical Significance of Microbial Infection and Adaptation in Cystic Fibrosis
Hauser, A. R., Jain, M., Bar-Meir, M., & McColley, S. A. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00036-10 · Cited by 411
Ouyang, J., Sun, F., Feng, W., Sun, Y., Qiu, X., Xiong, L., Liu, Y., & Chen, Y. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13073 · Cited by 286
Dixon, E. F., & Hall, R. A. (2015) · Cellular Microbiology · doi:10.1111/cmi.12490 · Cited by 73
Metadata
- Authors
- Winstanley, C., & Fothergill, J. L.
- Venue
- FEMS Microbiology Letters
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-01
- Volume
- 290
- Issue
- 1
- Pages
- 1-9
- ISSN
- 0378-1097 (ISSN-L)
- 1574-6968
- OpenAlex
- W2038404933
- Cited by
- 179
- References
- 1
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Winstanley, C., & Fothergill, J. L. (2009). The role of quorum sensing in chronic cystic fibrosis Pseudomonas aeruginosa infections. FEMS Microbiology Letters. https://doi.org/10.1111/j.1574-6968.2008.01394.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
