The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Quercetin is an effective inhibitor of quorum sensing, biofilm formation and virulence factors in Pseudomonas aeruginosa
Abstract
AIMS: The study aimed to perform a systematic investigation of the effects of quercetin on biofilm formation and virulence factors in Pseudomonas aeruginosa. METHODS AND RESULTS: The Ps. aeruginosa strain PAO1 was selected as the test strain. The results indicated that quercetin did not impact the growth of PAO1 as determined by MIC and growth curve analysis. However, this compound significantly inhibited (P < 0·05) biofilm formation and production of virulence factors including pyocyanin, protease and elastase at a lower concentration than those for most previously reported plant extracts and substances. Considering the central role of quorum sensing (QS) in the regulation of biofilm and virulence factor, we further detected the transcriptional changes associated with QS and found that the expression levels of lasI, lasR, rhlI and rhlR were significantly reduced (P < 0·05) by 34, 68, 57 and 50%, respectively, in response to 16 μg ml(-1) quercetin. CONCLUSIONS: This study indicated that quercetin is an effective inhibitor of biofilm formation and virulence factors in Ps. aeruginosa. SIGNIFICANCE AND IMPACT OF THE STUDY: This is the first study to demonstrate that quercetin is an effective inhibitor of QS, biofilm formation and virulence factors in Ps. aeruginosa. Furthermore, quercetin might have potential in fighting biofilm-related infections.
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Health effects of quercetin: From antioxidant to nutraceutical
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Eukaryotic interference with homoserine lactone-mediated prokaryotic signalling
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A network of networks: Quorum-sensing gene regulation in Pseudomonas aeruginosa
Schuster, M., & Peter Greenberg, E. (2006) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2006.01.036 · Cited by 646
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Quorum sensing in Pseudomonas aeruginosa biofilms
De Kievit, T. R. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2008.01792.x · Cited by 439
Azithromycin Inhibits Quorum Sensing in Pseudomonas aeruginosa
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Effects of Antibiotics on Quorum Sensing in Pseudomonas aeruginosa
Skindersoe, M. E., Alhede, M., Phipps, R., Yang, L., Jensen, P. O., Rasmussen, T. B., Bjarnsholt, T., Tolker-Nielsen, T., Høiby, N., & Givskov, M. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01230-07 · Cited by 364
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Pseudomonas aeruginosa Biofilms
Thi, M. T. T., Wibowo, D., & Rehm, B. H. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228671 · Cited by 911
Biofilms as Promoters of Bacterial Antibiotic Resistance and Tolerance
Uruén, C., Chopo-Escuin, G., Tommassen, J., Mainar-Jaime, R. C., & Arenas, J. (2020) · Antibiotics · doi:10.3390/antibiotics10010003 · Cited by 769
Paczkowski, J. E., Mukherjee, S., McCready, A. R., Cong, J.-P., Aquino, C. J., Kim, H., Henke, B. R., Smith, C. D., & Bassler, B. L. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.770552 · Cited by 319
Exploring phytochemicals for combating antibiotic resistance in microbial pathogens
Khare, T., Anand, U., Dey, A., Assaraf, Y. G., Chen, Z.-S., Liu, Z., & Kumar, V. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.720726 · Cited by 281
“The quercetin-mediated inhibition of biofilm formation was observed in P. aeruginosa PAO1 with reduced expression levels of the quorum sensing related genes (lasI, lasR, rhlI and rhlR) along with reduced production of virulence factors such as elastase, protease, and pyocyanin (Ouyang et al., 2016).”
BackgroundPseudomonas aeruginosa and microbial keratitis
Hilliam, Y., Kaye, S., & Winstanley, C. (2020) · Journal of Medical Microbiology · doi:10.1099/jmm.0.001110 · Cited by 152
Metadata
- Authors
- Ouyang, J., Sun, F., Feng, W., Sun, Y., Qiu, X., Xiong, L., Liu, Y., & Chen, Y.
- Venue
- Journal of Applied Microbiology
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-03-07
- Volume
- 120
- Issue
- 4
- Pages
- 966-974
- ISSN
- 1364-5072 (ISSN-L)
- OpenAlex
- W2277991016
- Cited by
- 286
- References
- 41
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ouyang, J., Sun, F., Feng, W., Sun, Y., Qiu, X., Xiong, L., Liu, Y., & Chen, Y. (2016). Quercetin is an effective inhibitor of quorum sensing, biofilm formation and virulence factors in Pseudomonas aeruginosa. Journal of Applied Microbiology. https://doi.org/10.1111/jam.13073
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