Cited by 20Antimicrobial Resistance in StaphylococcusBacterial Genetics and BiotechnologyIron Metabolism and Disorders

The iron-regulated surface proteins IsdA, IsdB, and IsdH are not required for heme iron utilization in Staphylococcus aureus

Hurd, Alexander F., Garcia-Lara, Jorge, Rauter, Yvonne, Cartron, Michaël, Mohamed, Ramlan, Foster, Simon J.·2012·FEMS Microbiology Letters

Abstract

The iron-regulated surface determinant proteins (Isd) of Staphylococcus aureus are expressed during iron limitation and have been proposed to be involved in the scavenging of iron from heme. In this study, the genes encoding the surface proteins IsdA, IsdB, and IsdH were inactivated in order to determine their combined role. The triple mutant was found to have no defect in growth under any conditions of iron limitation tested. Also using a mouse septic arthritis model of S. aureus systemic disease, no significant difference in bacterial load was observed for the triple mutant, compared with its otherwise isogenic parent.

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Crossref · 10.1111/j.1574-6968.2012.02502.x

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42 of 42 references verified0 citation errors · 0 not checkable

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Authors
Hurd, A. F., Garcia-Lara, J., Rauter, Y., Cartron, M., Mohamed, R., & Foster, S. J.
Affiliations
  • University of Sheffield (GB)
  • Krebs Institute, Department of Molecular Biology and Biotechnology; University of Sheffield; Sheffield; UK
Corresponding author
Foster, Simon J.
Venue
FEMS Microbiology Letters
Published
2012-02-09
Volume
329
Issue
1
Pages
93-100
ISSN
0378-1097 (ISSN-L)
OpenAlex
W2077486832
Cited by
20
References
42
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 5 · 2012: 1
FWCI
1.99
Type
journal article
Language
en
Open access
closed
Locations
  • FEMS Microbiology Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
ISDA, ISDB, IsdH, Staphylococcus aureus, iron limitation, iron acquisition, bacterial virulence, septic arthritis, gene inactivation
MeSH terms
Animals, Antigens, Bacterial, Arthritis, Infectious, Disease Models, Animal, Heme, Iron, Membrane Proteins, Receptors, Cell Surface, Staphylococcal Infections, Staphylococcus aureus, Gene Expression Regulation, Bacterial, Cation Transport Proteins, Mice, Gene Knockout Techniques, Bacterial Load

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