The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The phosphate regulon and bacterial virulence: a regulatory network connecting phosphate homeostasis and pathogenesis
Open accessAbstract
Bacterial pathogens regulate virulence factor gene expression coordinately in response to environmental stimuli, including nutrient starvation. The phosphate (Pho) regulon plays a key role in phosphate homeostasis. It is controlled by the PhoR/PhoB two-component regulatory system. PhoR is an integral membrane signaling histidine kinase that, through an interaction with the ABC-type phosphate-specific transport (Pst) system and a protein called PhoU, somehow senses environmental inorganic phosphate (P(i)) levels. Under conditions of P(i) limitation (or in the absence of a Pst component or PhoU), PhoR activates its partner response regulator PhoB by phosphorylation, which, in turn, up- or down-regulates target genes. Single-cell profiling of PhoB activation has shown recently that Pho regulon gene expression exhibits a stochastic, "all-or-none" behavior. Recent studies have also shown that the Pho regulon plays a role in the virulence of several bacteria. Here, we present a comprehensive overview of the role of the Pho regulon in bacterial virulence. The Pho regulon is clearly not a simple regulatory circuit for controlling phosphate homeostasis; it is part of a complex network important for both bacterial virulence and stress response.
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Cites
Stochastic Gene Expression in a Single Cell
Elowitz, M. B., Levine, A. J., Siggia, E. D., & Swain, P. S. (2002) · Science · doi:10.1126/science.1070919 · Cited by 5,441
Bacterial Persistence as a Phenotypic Switch
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952 · cited 1×
“All rights reserved Downloaded from https://academic.oup.com/femsre/article-abstract/32/3/461/2683226 by guest on 29 July 2018 is likely to have a huge impact on adaptation of bacterial pathogens within a host (Balaban et al., 2004; Kaern et al., 2005).”
BackgroundInorganic polyphosphate in the origin and survival of species
Brown, M. R. W., & Kornberg, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406909101 · Cited by 327
Cited by
The Pho regulon: a huge regulatory network in bacteria
Santos-Beneit, F. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00402 · Cited by 522
Fauvart, M., De Groote, V. N., & Michiels, J. (2011) · Journal of Medical Microbiology · doi:10.1099/jmm.0.030932-0 · Cited by 425
Gawronski, J. D., Wong, S. M. S., Giannoukos, G., Ward, D. V., & Akerley, B. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906627106 · Cited by 371
Mechanisms and Regulation of Intestinal Phosphate Absorption
Hernando, N., & Wagner, C. A. (2018) · Comprehensive Physiology · doi:10.1002/cphy.c170024 · Cited by 70
Candida albicans’ inorganic phosphate transport and evolutionary adaptation to phosphate scarcity
Acosta-Zaldívar, M., Qi, W., Mishra, A., Roy, U., King, W. R., Li, Y., Patton-Vogt, J., Anderson, M. Z., & Köhler, J. R. (2024) · PLOS Genetics · doi:10.1371/journal.pgen.1011156 · Cited by 14
Metadata
- Authors
- Lamarche, M. G., Wanner, B. L., Crépin, S., & Harel, J.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-05
- Volume
- 32
- Issue
- 3
- Pages
- 461-473
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W1786268878
- Cited by
- 490
- References
- 3
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lamarche, M. G., Wanner, B. L., Crépin, S., & Harel, J. (2008). The phosphate regulon and bacterial virulence: a regulatory network connecting phosphate homeostasis and pathogenesis. FEMS Microbiology Reviews. https://doi.org/10.1111/j.1574-6976.2008.00101.x
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