Role of persister cells in chronic infections: clinical relevance and perspectives on anti-persister therapies
Open accessAbstract
Certain infectious diseases caused by pathogenic bacteria are typically chronic in nature. Potentially deadly examples include tuberculosis, caused by Mycobacterium tuberculosis, cystic fibrosis-associated lung infections, primarily caused by Pseudomonas aeruginosa, and candidiasis, caused by the fungal pathogen Candida albicans. A hallmark of this type of illness is the recalcitrance to treatment with antibiotics, even in the face of laboratory tests showing the causative agents to be sensitive to drugs. Recent studies have attributed this treatment failure to the presence of a small, transiently multidrug-tolerant subpopulation of cells, so-called persister cells. Here, we review our current understanding of the role that persisters play in the treatment and outcome of chronic infections. In a second part, we offer a perspective on the development of anti-persister therapies based on genes and mechanisms that have been implicated in persistence over the last decade.
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In some cases, clinical antifungal treatment fails even without resistance, leading to breakthrough or recurrent infections.
“However, in some cases, even though devoid of resistance, the clinical treatment still failed, leading to breakthrough or recurrent infections [9–11].”
From Antifungal persistence: Clinical relevance and mechanisms (2025) · cites this paper as [11]
The Clinical relevance section (p. 1) says chronic infections can persist despite treatment when laboratory tests do not detect drug resistance. The Candidiasis section (p. 3) describes antifungal-tolerant Candida biofilm cells and links persistence to chronic infection, but it does not establish breakthrough infections or specifically report antifungal treatment failure without resistance. (LLM, conf=0.82)
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Cites
Bacterial Persistence as a Phenotypic Switch
Balaban, N. Q., Merrin, J., Chait, R., Kowalik, L., & Leibler, S. (2004) · Science · doi:10.1126/science.1099390 · Cited by 2,952 · see citing works
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
Sharma, S. V., Lee, D. Y., Li, B., Quinlan, M. P., Takahashi, F., Maheswaran, S., McDermott, U., Azizian, N., Zou, L., Fischbach, M. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.02.027 · Cited by 2,770 · see citing works
Persister cells, dormancy and infectious disease
Lewis, K. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1557 · Cited by 2,052 · see citing works
Lewis, K. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134306 · Cited by 1,858 · see citing works
Lung Infections Associated with Cystic Fibrosis
Lyczak, J. B., Cannon, C. L., & Pier, G. B. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.2.194-222.2002 · Cited by 1,634 · see citing works
Pathophysiology and Management of Pulmonary Infections in Cystic Fibrosis
Gibson, R. L., Burns, J. L., & Ramsey, B. W. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200304-505so · Cited by 1,629 · see citing works
Tuberculosis: Commentary on a Reemergent Killer
Bloom, B. R., & Murray, C. J. L. (1992) · Science · doi:10.1126/science.257.5073.1055 · Cited by 1,372 · see citing works
Genetic adaptation by <i>Pseudomonas aeruginosa</i> to the airways of cystic fibrosis patients
Smith, E. E., Buckley, D. G., Wu, Z., Saenphimmachak, C., Hoffman, L. R., D’Argenio, D. A., Miller, S. I., Ramsey, B. W., Speert, D. P., Moskowitz, S. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602138103 · Cited by 1,319 · see citing works
Persister cells and tolerance to antimicrobials
Keren, I., Kaldalu, N., Spoering, A. L., Wang, Y., & Lewis, K. (2003) · FEMS Microbiology Letters · doi:10.1016/s0378-1097(03)00856-5 · Cited by 1,099 · see citing works
Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis
Spencer, S. L., Gaudet, S., Albeck, J. G., Burke, J. M., & Sorger, P. K. (2009) · Nature · doi:10.1038/nature08012 · Cited by 1,023 · see citing works
Spoering, A. L., & Lewis, K. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.23.6746-6751.2001 · Cited by 907 · see citing works
Specialized Persister Cells and the Mechanism of Multidrug Tolerance in Escherichia coli
Keren, I., Shah, D., Spoering, A. L., Kaldalu, N., & Lewis, K. (2004) · Journal of Bacteriology · doi:10.1128/jb.186.24.8172-8180.2004 · Cited by 857 · see citing works
Nonreplicating Persistence of <i>Mycobacterium</i> <i>Tuberculosis</i>
Wayne, L. G., & Sohaskey, C. D. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.139 · Cited by 807 · see citing works
Pseudomonas aeruginosa – a phenomenon of bacterial resistance
Strateva, T., & Yordanov, D. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.009142-0 · Cited by 803 · see citing works
Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli
Dörr, T., Vulić, M., & Lewis, K. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000317 · Cited by 781 · see citing works
Moyed, H. S., & Bertrand, K. P. (1983) · Journal of Bacteriology · doi:10.1128/jb.155.2.768-775.1983 · Cited by 632 · see citing works
Persisters: a distinct physiological state of E. coli
Khodursky, A. B., Zhang, Z., Devang, S., Kaldalu, N., Kurg, K., & Lewis, K. (2006) · Digital Repository Service (Northeastern University) · doi:10.1186/1471-2180-6-53 · Cited by 630 · see citing works
Mulcahy, L. R., Burns, J. L., Lory, S. J., & Lewis, K. (2010) · Journal of Bacteriology · doi:10.1128/jb.01651-09 · Cited by 621 · see citing works
<i>Candida</i> biofilms on implanted biomaterials: a clinically significant problem
Ramage, G., MartÃnez, J. P., & López-Ribot, J. L. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00117.x · Cited by 575 · see citing works
Non-inherited antibiotic resistance
Levin, B. R., & Rozen, D. E. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1445 · Cited by 546 · see citing works
Ojha, A. K., Baughn, A. D., Sambandan, D., Hsu, T., Trivelli, X., Guérardel, Y., Alahari, A., Kremer, L., Jacobs, W. R., & Hatfull, G. F. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06274.x · Cited by 541 · see citing works
GLYCEROL DISSIMILATION AND ITS REGULATION IN BACTERIA
Lin, E. C. C. (1976) · Annual Review of Microbiology · doi:10.1146/annurev.mi.30.100176.002535 · Cited by 540 · see citing works
SOS Response Induces Persistence to Fluoroquinolones in Escherichia coli
Dörr, T., Lewis, K., & Vulić, M. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000760 · Cited by 530 · see citing works
<i>Candida albicans</i> Biofilms Produce Antifungal-Tolerant Persister Cells
LaFleur, M. D., Kumamoto, C. A., & Lewis, K. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00684-06 · Cited by 521 · see citing works
Lamarche, M. G., Wanner, B. L., Crépin, S., & Harel, J. (2008) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00101.x · Cited by 490 · see citing works
THE MAGIC BULLETS AND TUBERCULOSIS DRUG TARGETS
Zhang, Y. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.45.120403.100120 · Cited by 432 · see citing works
Korch, S. B., Henderson, T. A., & Hill, T. (2003) · Molecular Microbiology · doi:10.1046/j.1365-2958.2003.03779.x · Cited by 400 · see citing works
Regulation of phenotypic variability by a threshold-based mechanism underlies bacterial persistence
Rotem, E., Loinger, A., Ronin, I., Levin-Reisman, I., Gabay, C., Noam Shoresh, F., Biham, O., & Balaban, N. Q. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004333107 · Cited by 351 · see citing works
Molecular Mechanisms of HipA-Mediated Multidrug Tolerance and Its Neutralization by HipB
Schumacher, M. A., Piro, K. M., Xu, W., Hansen, S., Lewis, K., & Brennan, R. G. (2009) · Science · doi:10.1126/science.1163806 · Cited by 351 · cited 2× · see citing works
“Biochemical and structural studies have shown that the toxin HipA is a member of the phosphatidylinositol 3/4-kinase superfamily and can phosphorylate the translation factor EF-Tu (Schumacher et al., 2009).”
BackgroundInfluentialMicrobial ecology of the cystic fibrosis lung
Harrison, F. (2007) · Microbiology · doi:10.1099/mic.0.2006/004077-0 · Cited by 345 · see citing works
Microbial phenotypic heterogeneity and antibiotic tolerance
Dhar, N., & McKinney, J. D. (2007) · Current Opinion in Microbiology · doi:10.1016/j.mib.2006.12.007 · Cited by 335 · see citing works
Toxin–antitoxin systems: why so many, what for?
Melderen, L. V. (2010) · Current Opinion in Microbiology · doi:10.1016/j.mib.2010.10.006 · Cited by 313 · see citing works
The importance of being persistent: heterogeneity of bacterial populations under antibiotic stress
Gefen, O., & Balaban, N. Q. (2009) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00156.x · Cited by 313 · see citing works
Role of Global Regulators and Nucleotide Metabolism in Antibiotic Tolerance in Escherichia coli
Hansen, S., Lewis, K., & Vulić, M. (2008) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00144-08 · Cited by 297 · see citing works
Burns, J. L., Dalfsen, J. M. V., Shawar, R. M., Otto, K., Garber, R. L., Quan, J. M., Montgomery, A. B., Albers, G. M., Ramsey, B. W., & Smith, A. L. (1999) · The Journal of Infectious Diseases · doi:10.1086/314727 · Cited by 289 · see citing works
The Small RNA IstR Inhibits Synthesis of an SOS-Induced Toxic Peptide
Vogel, J., Argaman, L., Wagner, E. G. H., & Altuvia, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.12.003 · Cited by 277 · see citing works
Möker, N., Dean, C. R., & Tao, J. (2010) · Journal of Bacteriology · doi:10.1128/jb.01231-09 · Cited by 243 · see citing works
Patients with Long-Term Oral Carriage Harbor High-Persister Mutants of <i>Candida albicans</i>
LaFleur, M. D., Qi, Q., & Lewis, K. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00860-09 · Cited by 237 · see citing works
Li, Y.-F., & Zhang, Y. (2007) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00052-07 · Cited by 222 · see citing works
Antibiotic tolerance among clinical isolates of bacteria
TUOMANEN, E. I., Durack, D. T., & Tomasz, A. (1986) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.30.4.521 · Cited by 218 · see citing works
GlpD and PlsB Participate in Persister Cell Formation in Escherichia coli
Spoering, A. L., Vulić, M., & Lewis, K. (2006) · Journal of Bacteriology · doi:10.1128/jb.00369-06 · Cited by 214 · see citing works
Letting SleepingdosLie: Does Dormancy Play a Role in Tuberculosis?
Chao, M. C., & Rubin, E. J. (2010) · Annual Review of Microbiology · doi:10.1146/annurev.micro.112408.134043 · Cited by 210 · see citing works
Karkare, S., & Bhatnagar, D. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0434-2 · Cited by 207 · see citing works
CORREIA, F. F., Donofrio, A. E., Rejtar, T., Li, L., Karger, B. L., Makarova, K. S., Koonin, E. V., & Lewis, K. (2006) · Journal of Bacteriology · doi:10.1128/jb.01237-06 · Cited by 199 · see citing works
Persistent and dormant tubercle bacilli and latent tuberculosis
Zhang, Y. (2004) · Frontiers in bioscience · doi:10.2741/1291 · Cited by 195 · see citing works
Exit from dormancy in microbial organisms
Dworkin, J. E., & Shah, I. M. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2453 · Cited by 194 · see citing works
Selective Killing of Nonreplicating Mycobacteria
Bryk, R., Gold, B., Venugopal, A., Singh, J., Samy, R. D., Pupek, K., Cao, H., Popescu, C., Gurney, M., Hotha, S., et al. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.003 · Cited by 184 · see citing works
Moyed, H. S., & Broderick, S. H. (1986) · Journal of Bacteriology · doi:10.1128/jb.166.2.399-403.1986 · Cited by 176 · see citing works
Black, D. S., Kelly, A. J., Mardis, M. J., & Moyed, H. S. (1991) · Journal of Bacteriology · doi:10.1128/jb.173.18.5732-5739.1991 · Cited by 161 · see citing works
Bacterial persistence: some new insights into an old phenomenon
Jayaraman, R. (2008) · Journal of Biosciences · doi:10.1007/s12038-008-0099-3 · Cited by 157 · see citing works
Modelling protection from antimicrobial agents in biofilms through the formation of persister cells
Roberts, M. E., & Stewart, P. S. (2005) · Microbiology · doi:10.1099/mic.0.27385-0 · Cited by 153 · see citing works
Black, D. S., Irwin, B., & Moyed, H. S. (1994) · Journal of Bacteriology · doi:10.1128/jb.176.13.4081-4091.1994 · Cited by 150 · see citing works
Chandra, J., Patel, J. D., Li, J., Zhou, G., Mukherjee, P. K., McCormick, T. S., Anderson, J. M., & Ghannoum, M. A. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8795-8801.2005 · Cited by 142 · see citing works
Nanoscale Investigation of Pathogenic Microbial Adhesion to a Biomaterial
Emerson, R. J., & Camesano, T. A. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.6012-6022.2004 · Cited by 137 · see citing works
Novel persistence genes in Pseudomonas aeruginosa identified by high-throughput screening
Groote, V. N. D., Verstraeten, N., Fauvart, M., Kint, C. I., Verbeeck, A. M., Beullens, S., Cornélis, P., & Michiels, J. J. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01657.x · Cited by 134 · see citing works
Self-citationDrug Tolerance in Mycobacterium tuberculosis
Wallis, R. S., Patil, S. A., Cheon, S.-H., et al. (1999) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.43.11.2600 · Cited by 125 · see citing works
Fung, D. K. C., Chan, E. W., Chin, M. L., & Chan, R. C. Y. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01218-09 · Cited by 118 · see citing works
Scherrer, R., & Moyed, H. S. (1988) · Journal of Bacteriology · doi:10.1128/jb.170.8.3321-3326.1988 · Cited by 103 · see citing works
Vidučić, D., Ono, T., Murakami, K., et al. (2006) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2006.tb03793.x · Cited by 94 · see citing works
PhoY2 but not PhoY1 is the PhoU homologue involved in persisters in Mycobacterium tuberculosis
Shi, W. K., & Zhang, Y. (2010) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkq103 · Cited by 57 · see citing works
The role ofrpoSgene and quorum-sensing system in ofloxacin tolerance inPseudomonas aeruginosa
Kayama, S., Murakami, K., Ono, T., Ushimaru, M., Yamamoto, A., Hirota, K., & Miyake, Y. (2009) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2009.01717.x · Cited by 51 · see citing works
Structural Basis of Substrate Selectivity in the Glycerol-3-Phosphate: Phosphate Antiporter GlpT
Law, C. J., Enkavi, G., Wang, D., et al. (2009) · Biophysical Journal · doi:10.1016/j.bpj.2009.06.026 · Cited by 49 · see citing works
Failure of antibiotic treatment in microbial populations
Leenheer, P. D., & Cogan, N. G. (2008) · Journal of Mathematical Biology · doi:10.1007/s00285-008-0243-6 · Cited by 48 · see citing works
Antibiotic Persistence: The Role of Spontaneous DNA Repair Response
Debbia, E. A., Roveta, S., Schito, A. M., Gualco, L., & Marchese, A. E. (2001) · Microbial Drug Resistance · doi:10.1089/10766290152773347 · Cited by 48 · see citing works
Small Molecules for Interference with Cell-Cell-Communication Systems in Gram-Negative Bacteria
Janssens, J., Keersmaecker, S. C. J. D., Vos, D. E. D., et al. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708785747580 · Cited by 45 · see citing works
Groote, V. N. D., Fauvart, M., Kint, C. I., Verstraeten, N., Jans, A., Cornélis, P., & Michiels, J. J. (2011) · Journal of Medical Microbiology · doi:10.1099/jmm.0.019703-0 · Cited by 39 · see citing works
Self-citationPathogenesis of cystic fibrosis airways disease.
Boucher, R. (2001) · PubMed · Cited by 24 · see citing works
Gilligan, P. H. (2006) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.4.5.711 · Cited by 22 · see citing works
Hu, Y., & Coates, A. R. M. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511546242.008 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- Chabner, B. A. (2006). Clinical strategies for cancer treatment: the role of drugs. In Cancer Chemotherapy and Biotherapy: Principles and Practices , 4th edn, pp. 1-14. Edited by B. A. Chabner & D. L. Longo. Philadelphia, PA: Lippincott Williams & Wilkins.
- WHO (2009). WHO Report 2009: Global Tuberculosis Control. Epidemiology, Strategy, Financing . Geneva, Switzerland: World Health Organization Press.
Cited by
Sorted by citations
Sardi, J. C. O., Scorzoni, L., Bernardi, T., Fusco-Almeida, A. M., & Mendes Giannini, M. J. S. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.045054-0 · Cited by 1,184 · see citing works
Antibiotic resistance and persistence—implications for human health and treatment perspectives
Huemer, M., Mairpady Shambat, S., Brugger, S. D., & Zinkernagel, A. S. (2020) · The EMBO Reports · doi:10.15252/embr.202051034 · Cited by 850 · see citing works
Ramage, G., Rajendran, R., Sherry, L., & Williams, C. (2012) · International Journal of Microbiology · doi:10.1155/2012/528521 · Cited by 583 · see citing works
Intracellular Staphylococcus aureus persisters upon antibiotic exposure
Peyrusson, F., Varet, H., Nguyen, T. K., Legendre, R., Sismeiro, O., Coppée, J.-Y., Wolz, C., Tenson, T., & Van Bambeke, F. (2020) · Nature Communications · doi:10.1038/s41467-020-15966-7 · Cited by 392 · see citing works
Fighting bacterial persistence: Current and emerging anti-persister strategies and therapeutics
Defraine, V., Fauvart, M., & Michiels, J. (2018) · Drug Resistance Updates · doi:10.1016/j.drup.2018.03.002 · Cited by 222 · see citing works
Self-citationPersistence: mechanisms for triggering and enhancing phenotypic variability
Balaban, N. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2011.10.001 · Cited by 156 · see citing works
Li, P., Seneviratne, C. J., Alpi, E., Vizcaino, J. A., & Jin, L. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00543-15 · Cited by 95 · see citing works
Ahmadi, M. S., Lee, H. H., Sanchez, D. A., Friedman, A. J., Tar, M. T., Davies, K. P., Nosanchuk, J. D., & Martinez, L. R. (2016) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02659-15 · Cited by 41 · see citing works
Oxidative imbalance in Candida tropicalis biofilms and its relation with persister cells
da Silva, M. A., Baronetti, J. L., Páez, P. L., & Paraje, M. G. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.598834 · Cited by 28 · see citing works
Antifungal persistence: Clinical relevance and mechanisms
Wang, R., Lv, J., Chen, L., Zhao, Y., & Du, H. (2025) · PLoS pathogens · doi:10.1371/journal.ppat.1013456 · Cited by 12 · see citing works
Flow cytometry-based method to detect persisters in Candida albicans
Chang, W., Zhang, M., Li, Y., & Lou, H. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00255-15 · Cited by 7 · see citing works
- Authors
- Fauvart, M., De Groote, V. N., & Michiels, J.
- Affiliations
- KU Leuven (BE)
- Centre of Microbial and Plant Genetics, K.U.Leuven, Leuven, Belgium
- Venue
- Journal of Medical Microbiology
- Publisher
- Microbiology Society
- Published
- 2011-06-01
- Volume
- 60
- Issue
- 6
- Pages
- 699-709
- ISSN
- 0022-2615 (ISSN-L)
- 1473-5644
- OpenAlex
- W2101937561
- Cited by
- 425
- References
- 69
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 21 · 2023: 31 · 2022: 26 · 2021: 34 · 2020: 39 · 2019: 29 · 2018: 36 · 2017: 27 · 2016: 35 · 2015: 39 · 2014: 31 · 2013: 13 · 2012: 22
- FWCI
- 2.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Journal of Medical Microbiology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
- Lirias (submittedVersion, other-oa)
- Funders
- Fonds Wetenschappelijk Onderzoek (G.0413.10)
- Vlaamse regering
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Keywords
- persister cells, chronic bacterial infection, antibiotic tolerance, multidrug tolerance, tuberculosis, Mycobacterium tuberculosis, Pseudomonas aeruginosa, cystic fibrosis lung infection, Candida albicans, candidiasis, persistence mechanisms
- MeSH terms
- Anti-Infective Agents, Candida albicans, Candidiasis, Chronic Disease, Cystic Fibrosis, Humans, Mycobacterium tuberculosis, Pseudomonas aeruginosa, Pseudomonas Infections, Tuberculosis, Pneumonia, Bacterial
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