The DOI matches its Crossref record; 99 of the 99 references it cites were found in a registry or an index.
The Pho regulon: a huge regulatory network in bacteria
Open accessAbstract
One of the most important achievements of bacteria is its capability to adapt to the changing conditions of the environment. The competition for nutrients with other microorganisms, especially in the soil, where nutritional conditions are more variable, has led bacteria to evolve a plethora of mechanisms to rapidly fine-tune the requirements of the cell. One of the essential nutrients that are normally found in low concentrations in nature is inorganic phosphate (Pi). Bacteria, as well as other organisms, have developed several systems to cope for the scarcity of this nutrient. To date, the unique mechanism responding to Pi starvation known in detail is the Pho regulon, which is normally controlled by a two component system and constitutes one of the most sensible and efficient regulatory mechanisms in bacteria. Many new members of the Pho regulon have emerged in the last years in several bacteria; however, there are still many unknown questions regarding the activation and function of the whole system. This review describes the most important findings of the last three decades in relation to Pi regulation in bacteria, including: the PHO box, the Pi signaling pathway and the Pi starvation response. The role of the Pho regulon in nutritional regulation cross-talk, secondary metabolite production, and pathogenesis is discussed in detail.
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Cites
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Cited by
Antimicrobial Effect of Titanium Dioxide Nanoparticles
López de Dicastillo, C., Guerrero Correa, M., B. Martínez, F., Streitt, C., & José Galotto, M. (2021) · Antimicrobial Resistance - A One Health Perspective · doi:10.5772/intechopen.90891 · Cited by 159
Candida albicans’ inorganic phosphate transport and evolutionary adaptation to phosphate scarcity
Acosta-Zaldívar, M., Qi, W., Mishra, A., Roy, U., King, W. R., Li, Y., Patton-Vogt, J., Anderson, M. Z., & Köhler, J. R. (2024) · PLOS Genetics · doi:10.1371/journal.pgen.1011156 · Cited by 14
Metadata
- Authors
- Santos-Beneit, F.
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2015-04-30
- Volume
- 6
- Pages
- 402-402
- ISSN
- 1664-302X (ISSN-L)
- OpenAlex
- W1976381180
- Cited by
- 522
- References
- 99
- FWCI
- 19.74
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
