The DOI matches its Crossref record; 157 of the 157 references it cites were found in a registry or an index.
The molecular basis of herpes simplex virus latency
Open accessAbstract
Herpes simplex virus type 1 is a neurotropic herpesvirus that establishes latency within sensory neurones. Following primary infection, the virus replicates productively within mucosal epithelial cells and enters sensory neurones via nerve termini. The virus is then transported to neuronal cell bodies where latency can be established. Periodically, the virus can reactivate to resume its normal lytic cycle gene expression programme and result in the generation of new virus progeny that are transported axonally back to the periphery. The ability to establish lifelong latency within the host and to periodically reactivate to facilitate dissemination is central to the survival strategy of this virus. Although incompletely understood, this review will focus on the mechanisms involved in the regulation of latency that centre on the functions of the virus-encoded latency-associated transcripts (LATs), epigenetic regulation of the latent virus genome and the molecular events that precipitate reactivation.
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Bourgade, K., Garneau, H., Giroux, G., Le Page, A. Y., Bocti, C., Dupuis, G., Frost, E. H., & Fülöp, T. (2015) · Biogerontology · doi:10.1007/s10522-014-9538-8 · Cited by 208
Herpes Virus Reactivation in Astronauts During Spaceflight and Its Application on Earth
Rooney, B. V., Crucian, B. E., Pierson, D. L., Laudenslager, M. L., & Mehta, S. K. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00016 · Cited by 174
Bourgade, K., Le Page, A., Bocti, C., Witkowski, J. M., Dupuis, G., Frost, E. H., & Fülöp, T. (2016) · Journal of Alzheimer’s Disease · doi:10.3233/jad-150652 · Cited by 161
A reappraisal on amyloid cascade hypothesis: The role of chronic infection in Alzheimer’s disease
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Metadata
- Authors
- Nicoll, M. P., Proença, J. T., & Efstathiou, S.
- Venue
- FEMS Microbiology Reviews
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-05
- Volume
- 36
- Issue
- 3
- Pages
- 684-705
- ISSN
- 0168-6445 (ISSN-L)
- 1574-6976
- OpenAlex
- W2122466812
- Cited by
- 286
- References
- 157
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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