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Cited by 700

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Herpes Simplex Viruses

Whitley, Richard J., Roizman, Bernard·2002·Wiley Encyclopedia of Molecular Medicine
DOI 10.1002/0471203076.emm0597
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Abstract

Herpes simplex virus (HSV) infections of humans have been documented since the advent of writing. The spectrum of disease was expanded to include primary and recurrent infections of mucous membranes (gingivostomatitis, herpes labialis, and genital HSV infections), keratoconjunctivitis, neonatal HSV infection, visceral HSV infections of the immunocompromised host, HSV encephalitis, Kaposi's varicella-like eruption, and an association with erythema multiforme. Cumulative experience suggests that factors associated with pregnancy may place both the mother and fetus at increased risk for severe infection, possibly because of altered cell-mediated immunity. The major risk to the fetus is with primary or initial genital HSV infection of the mother. PCR evaluation of cerebrospinal fluid can be utilized to monitor therapeutic outcome in patients with herpes simplex encephalitis. The use of HSV for gene therapy heralds a new era of herpes biology, the conversion of a hazardous foe into a user-friendly surgical tool. Asymptomatic shedding of virus can continue despite clinically effective suppression with acyclovir, so the possibility of person-to-person transmission persists. Newborns with HSV infections can be classified as having disease that is localized to the skin, eyes, and mouth; affects the central nervous system (CNS); or is disseminated. Drug resistance was considered rare and resistant isolates were thought to be less pathogenic until a series of acyclovir-resistant HSV isolates from patients with AIDS were characterized. The risk of nephrotoxicity can be minimized by administering acyclovir by slow infusion and ensuring adequate hydration.

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Metadata

Authors
Whitley, R. J., & Roizman, B.
Venue
Wiley Encyclopedia of Molecular Medicine
Publisher
Wiley
Published
2002-01-15
Pages
409-436
DOI
10.1002/0471203076.emm0597
OpenAlex
W2610208464
Cited by
700
References
9
Type
reference entry
Language
en
Open access
closed

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CoChat. (2026). Citation check: Herpes Simplex Viruses. https://app.cochat.ai/papers/10.1002/0471203076.emm0597
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Whitley, R. J., & Roizman, B. (2002). Herpes Simplex Viruses. Wiley Encyclopedia of Molecular Medicine. https://doi.org/10.1002/0471203076.emm0597

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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