Association of refractory complex partial seizures with a polymorphism of ApoE genotype
Open accessAbstract
Apolipoprotein E (ApoE) is a constituent of many types of lipoproteins that play a role in metabolism of cholesterol and lipids in the body as well as in the brain. ApoE is synthesised in astrocytes and microglia and enter to neurons through LDL, LRP and VLDL receptors. Recently it was shown that ApoE is also produced in neurons. ApoE has a role in modulating learning and memory, structural plasticity, mobilization of cholesterol in repair, growth and maintenance of myelin and neuronal membranes during development and aging, and cell death after ischemic, convulsive, or other type of brain injury. The aim of this research was to investigate the possible association of ApoE gene polymorphism with the development of resistance to pharmacological therapy in patients with partial complex seizures with or without secondary generalization. In this prospective matched-pair controlled study, 60 patients with cryptogenic epilepsy with complex partial seizures, with or without secondary generalization, who have been suffering for five or more years, were studied. The first group comprised 30 patients refractory to the current therapy, while the second group consisted of patients with well-controlled seizures. The refractory and non-refractory groups of patients differed significantly in their phenotypes. Phenotype E3/4 was six times more frequent in refractory group than among non-refractory group. The lack of response was shown to be significantly associated with the presence of epsilon4 allele. This study provided evidence that the presence of epsilon4 allele is more often associated with a lack of response to current antiepileptic drugs as compared to epsilon2 and epsilon3 alleles.
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Epilepsy patients with at least one APOE4 allele are six times more likely to exhibit treatment resistance.
“epilepsy patients with at least one APOE4 allele are six times more likely to exhibit treatment resistance [141].”
From Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease (2019) · cites this paper as [141]
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Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease
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- Authors
- Sporiš, D., Sertic, J., Henigsberg, N., Mahovic, D., Bogdanovic, N., & Babic, T.
- Affiliations
- University Hospital Centre Zagreb (HR)
- Klinika za psihijatriju Vrapče (HR)
- Corresponding author
- Sporiš, Davor
- ORCID
- Henigsberg, Neven
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2005-07
- Volume
- 9
- Issue
- 3
- Pages
- 698-703
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- PMC
- PMC6741410
- OpenAlex
- W1973789619
- Cited by
- 26
- References
- 29
- Citations by year
- 2026: 2 · 2024: 2 · 2019: 2 · 2017: 1 · 2016: 4 · 2015: 1 · 2012: 1
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cellular and Molecular Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Keywords
- apolipoprotein E, APOE polymorphism, complex partial seizures, drug-resistant epilepsy, secondary generalization, ε4 allele, antiepileptic drug resistance, cryptogenic epilepsy
- MeSH terms
- Anticonvulsants, Apolipoproteins E, Genotype, Humans, Middle Aged, Pilot Projects, Polymorphism, Genetic, Reference Values, Epilepsy, Complex Partial
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