The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Endothelial progenitor cells: identity defined?
Open accessAbstract
Introduction The proof‐of‐concept in vivo: the cell, the read‐out and the animal model EPCs defined in vitro: the achilles heel in EPC biology Summary In the past decade, researchers have gained important insights on the role of bone marrow (BM)‐derived cells in adult neovascularization. A subset of BM‐derived cells, called endothelial progenitor cells (EPCs), has been of particular interest, as these cells were suggested to home to sites of neovascularization and neoendothelialization and differentiate into endothelial cells (ECs) in situ, a process referred to as postnatal vasculogenesis. Therefore, EPCs were proposed as a potential regenerative tool for treating human vascular disease and a possible target to restrict vessel growth in tumour pathology. However, conflicting results have been reported in the field, and the identification, characterization, and exact role of EPCs in vascular biology is still a subject of much discussion. The focus of this review is on the controversial issues in the field of EPCs which are related to the lack of a unique EPC marker, identification challenges related to the paucity of EPCs in the circulation, and the important phenotypical and functional overlap between EPCs, haematopoietic cells and mature ECs. We also discuss our recent findings on the origin of endothelial outgrowth cells (EOCs), showing that this in vitro defined EC population does not originate from circulating CD133+ cells or CD45+ haematopoietic cells.
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Cites
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Cited by
Masuda, H., Matsuzaki, Y., Hiratsu, E., Ono, M., Nagashima, T., Kajitani, T., Arase, T., Oda, H., Uchida, H., Asada, H., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010387 · Cited by 303
Stem cell theory for the pathogenesis of endometriosis
Maruyama, T. (2012) · Frontiers in Bioscience · doi:10.2741/e589 · Cited by 109
Miyazaki, K., Maruyama, T., Masuda, H., Yamasaki, A., Uchida, S., Oda, H., Uchida, H., & Yoshimura, Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0050749 · Cited by 76
Metadata
- Authors
- Timmermans, F., Plum, J., Yöder, M. C., Ingram, D. A., Vandekerckhove, B., & Case, J.
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2009-01
- Volume
- 13
- Issue
- 1
- Pages
- 87-102
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- OpenAlex
- W1979485167
- Cited by
- 497
- References
- 9
- FWCI
- 18.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Timmermans, F., Plum, J., Yöder, M. C., Ingram, D. A., Vandekerckhove, B., & Case, J. (2009). Endothelial progenitor cells: identity defined? Journal of Cellular and Molecular Medicine. https://doi.org/10.1111/j.1582-4934.2008.00598.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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