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Molecular characterization and functional properties of cardiomyocytes derived from human inducible pluripotent stem cells
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In view of the therapeutic potential of cardiomyocytes derived from induced pluripotent stem (iPS) cells (iPS‐derived cardiomyocytes), in the present study we investigated in iPS‐derived cardiomyocytes, the functional properties related to [Ca 2+]i handling and contraction, the contribution of the sarcoplasmic reticulum (SR) Ca 2+ release to contraction and the b‐adrenergic inotropic responsiveness. The two iPS clones investigated here were generated through infection of human foreskin fibroblasts (HFF) with retroviruses containing the four human genes: OCT4, Sox2, Klf4 and C‐Myc. Our major findings showed that iPS‐derived cardiomyocytes: (i) express cardiac specific RNA and proteins; (ii) exhibit negative force–frequency relations and mild (compared to adult) post‐rest potentiation; (iii) respond to ryanodine and caffeine, albeit less than adult cardiomyocytes, and express the SR‐Ca 2+ handling proteins ryanodine receptor and calsequestrin. Hence, this study demonstrates that in our cardiomyocytes clones differentiated from HFF‐derived iPS, the functional properties related to excitation–contraction coupling, resemble in part those of adult cardiomyocytes.
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“Our observation of isoproterenol-induced stroke work reduction (Fig. 3b) is consistent with negative force-frequency relationships observed in tissues based on immature cardiomyocytes, including NRVM71 and hiPSC-CM72.”
From A tissue-engineered scale model of the heart ventricle (2018) · cites this paper as [72]
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Cites
Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Embryonic Stem Cell Lines Derived from Human Blastocysts
Thomson, J. A., Itskovitz‐Eldor, J., Shapiro, S. S., Waknitz, M. A., Swiergiel, J. J., Marshall, V. S., & Jones, J. M. (1998) · Science · doi:10.1126/science.282.5391.1145 · Cited by 15,947
Self-citationCardiac excitation–contraction coupling
Bers, D., & Despa, S. (2002) · Nature · doi:10.1038/415198a · Cited by 4,927
Feeder-free growth of undifferentiated human embryonic stem cells
Xu, C., Inokuma, M. S., Denham, J., Golds, K., Kundu, P., Gold, J. D., & Carpenter, M. K. (2001) · Nature Biotechnology · doi:10.1038/nbt1001-971 · Cited by 1,872
Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells
Zhang, J., Wilson, G. F., Soerens, A. G., Koonce, C. H., Yu, J., Palecek, S. P., Thomson, J. A., & Kamp, T. J. (2009) · Circulation Research · doi:10.1161/circresaha.108.192237 · Cited by 1,426
Stem-cell therapy for cardiac disease
Segers, V. F. M., & Lee, R. T. (2008) · Nature · doi:10.1038/nature06800 · Cited by 1,192
Stem-cell-based therapy and lessons from the heart
Passier, R. C., Laake, L. W. V., & Mummery, C. L. (2008) · Nature · doi:10.1038/nature07040 · Cited by 528
Generation of Functional Murine Cardiac Myocytes From Induced Pluripotent Stem Cells
Mauritz, C., Schwanke, K., Reppel, M., Neef, S., Katsirntaki, K., Maier, L. S., Nguemo, F., Menke, S., Haustein, M., Hescheler, J., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.778795 · Cited by 490
Formation of Human Myocardium in the Rat Heart from Human Embryonic Stem Cells
Laflamme, M. A., Gold, J., Xu, C., Hassanipour, M., Rosler, E. S., Police, S., Muskheli, V., & Murry, C. E. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62041-x · Cited by 448
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Yang, X., Pabon, L., & Murry, C. E. (2014) · Circulation Research · doi:10.1161/circresaha.114.300558 · Cited by 939
Ma, J., Guo, L., Fiene, S., Anson, B. D., Thomson, J. A., Kamp, T. J., Kolaja, K. L., Swanson, B. J., & January, C. T. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00694.2011 · Cited by 787
Kawamura, M., Miyagawa, S., Miki, K., Saito, A., Fukushima, S., Higuchi, T., Kawamura, T., Kuratani, T., Daimon, T., Shimizu, T., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.084343 · Cited by 503
Ruan, J.-L., Tulloch, N. L., Razumova, M. V., Saiget, M., Muskheli, V., Pabon, L., Reinecke, H., Regnier, M., & Murry, C. E. (2016) · Circulation · doi:10.1161/circulationaha.114.014998 · Cited by 467
Evolution of strategies to improve preclinical cardiac safety testing
Gintant, G., Sager, P. T., & Stockbridge, N. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.34 · Cited by 407
Concise Review: Maturation Phases of Human Pluripotent Stem Cell-Derived Cardiomyocytes
Robertson, C., Tran, D., & George, S. C. (2013) · Stem Cells · doi:10.1002/stem.1331 · Cited by 372
Kamakura, T., Makiyama, T., Sasaki, K., Yoshida, Y., Wuriyanghai, Y., Chen, J., Hattori, T., Ohno, S., Kita, T., Horie, M., et al. (2013) · Circulation Journal · doi:10.1253/circj.cj-12-0987 · Cited by 295
Immaturity of Human Stem-Cell-Derived Cardiomyocytes in Culture: Fatal Flaw or Soluble Problem?
Veerman, C. C., Kosmidis, G., Mummery, C. L., Casini, S., Verkerk, A. O., & Bellin, M. (2015) · Stem Cells and Development · doi:10.1089/scd.2014.0533 · Cited by 284
Induced Pluripotent Stem Cells 10 Years Later
Yoshida, Y., & Yamanaka, S. (2017) · Circulation Research · doi:10.1161/circresaha.117.311080 · Cited by 282
Maturing human pluripotent stem cell-derived cardiomyocytes in human engineered cardiac tissues
Feric, N. T., & Radisic, M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.04.019 · Cited by 247
A tissue-engineered scale model of the heart ventricle
MacQueen, L. A., Sheehy, S. P., Chantre, C. O., Zimmerman, J. F., Pasqualini, F. S., Liu, X., Goss, J. A., Campbell, P. H., Gonzalez, G. M., Park, S.-J., et al. (2018) · Nature Biomedical Engineering · doi:10.1038/s41551-018-0271-5 · Cited by 227
Dar, A., Domev, H., Ben-Yosef, O., Tzukerman, M., Zeevi‐Levin, N., Novak, A., Germanguz, I., Amit, M., & Itskovitz‐Eldor, J. (2011) · Circulation · doi:10.1161/circulationaha.111.048264 · Cited by 214
Self-citationChurko, J. M., Garg, P., Treutlein, B., Venkatasubramanian, M., Wu, H., Lee, J., Wessells, Q. N., Chen, S.-Y., Chen, W.-Y., Chetal, K., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07333-4 · Cited by 207
Karakikes, I., Stillitano, F., Nonnenmacher, M. E., Tzimas, C., Sanoudou, D., Termglinchan, V., Kong, C., Rushing, S. N., Hansen, J., Ceholski, D. K., et al. (2015) · Nature Communications · doi:10.1038/ncomms7955 · Cited by 206
In vitro Modeling of Ryanodine Receptor 2 Dysfunction Using Human Induced Pluripotent Stem Cells
Fatima, A., Xu, G., Shao, K., Papadopoulos, S., Lehmann, M., Arnáiz‐Cot, J. J., Rosa, A. O., Nguemo, F., Matzkies, M., Dittmann, S., et al. (2011) · Cellular Physiology and Biochemistry · doi:10.1159/000335753 · Cited by 204
Human engineered heart tissue as a model system for drug testing
Eder, A., Vollert, I., Hansen, A., & Eschenhagen, T. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.05.010 · Cited by 190
Calcium Handling in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes
Itzhaki, I., Rapoport, S., Huber, I., Mizrahi, I., Zwi‐Dantsis, L., Arbel, G., Schiller, J., & Gepstein, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018037 · Cited by 195
Novak, A., Barad, L., Zeevi‐Levin, N., Shick, R., Shtrichman, R., Lorber, A., Itskovitz‐Eldor, J., & Binah, O. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01476.x · Cited by 182
Self-citationKoivumäki, J. T., Naumenko, N. V., Tuomainen, T., Takalo, J., Oksanen, M., Puttonen, K. A., Lehtonen, Š., Kuusisto, J., Laakso, M., Koıstınaho, J., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00080 · Cited by 172
Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories
Hwang, H. S., Kryshtal, D. O., Feaster, T. K., Sánchez-Freire, V., Zhang, J., Kamp, T. J., Hong, C. C., Wu, J. C., & Knollmann, B. C. (2015) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2015.05.003 · Cited by 182
Yücel, G., Zhao, Z., El‐Battrawy, I., Lan, H., Lang, S., Li, X., Buljubasic, F., Zimmermann, W., Cyganek, L., Utikal, J. S., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-03147-4 · Cited by 166
Gherghiceanu, M., Barad, L., Novak, A., Reiter, I., Itskovitz‐Eldor, J., Binah, O., & Popescu, L. M. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01417.x · Cited by 163
Self-citationHuman induced pluripotent stem cells and their use in drug discovery for toxicity testing
Scott, C. W., Peters, M. F., & Dragan, Y. P. (2013) · Toxicology Letters · doi:10.1016/j.toxlet.2013.02.020 · Cited by 157
Dynamic suspension culture for scalable expansion of undifferentiated human pluripotent stem cells
Amit, M., Laevsky, I., Miropolski, Y., Shariki, K., Peri, M., & Itskovitz‐Eldor, J. (2011) · Nature Protocols · doi:10.1038/nprot.2011.325 · Cited by 143
Self-citationMandel, Y., Weissman, A., Schick, R., Barad, L., Novak, A., Meiry, G., Goldberg, S., Lorber, A., Rosen, M. R., Itskovitz‐Eldor, J., et al. (2012) · Circulation · doi:10.1161/circulationaha.111.045146 · Cited by 127
Self-citationMagdy, T., Schuldt, A. J. T., Wu, J. C., Bernstein, D., & Burridge, P. W. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-053110 · Cited by 117
Scott, C. W., Zhang, X., Abi‐Gerges, N., Lamore, S. D., Abassi, Y. A., & Peters, M. F. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu186 · Cited by 106
Current status of drug screening and disease modelling in human pluripotent stem cells
Rajamohan, D., Matsa, E., Kalra, S., Crutchley, J., Patel, A. K., George, V. T., & Denning, C. N. (2012) · BioEssays · doi:10.1002/bies.201200053 · Cited by 104
Novak, A., Barad, L., Lorber, A., Gherghiceanu, M., Reiter, I., Eisen, B., Eldor, L., Itskovitz‐Eldor, J., Eldar, M., Arad, M., et al. (2015) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12581 · Cited by 101
Self-citationPeters, M. F., Lamore, S. D., Guo, L., Scott, C. W., & Kolaja, K. L. (2014) · Cardiovascular Toxicology · doi:10.1007/s12012-014-9268-9 · Cited by 91
Gupta, M. K., Illich, D. J., Gaarz, A., Matzkies, M., Nguemo, F., Pfannkuche, K., Liang, H., Claßen, S., Reppel, M., Schultze, J. L., et al. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-98 · Cited by 91
The long and winding road of cardiomyocyte maturation
Maroli, G., & Braun, T. W. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa159 · Cited by 89
Electro-mechanical conditioning of human iPSC-derived cardiomyocytes for translational research
Kroll, K. T., Chabria, M., Wang, K., Häusermann, F., Schuler, F., & Polonchuk, L. (2017) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2017.07.003 · Cited by 89
Keung, W., Boheler, K. R., & Li, R. A. (2014) · Stem Cell Research & Therapy · doi:10.1186/scrt406 · Cited by 87
Bekhite, M. M., Delgado, A. G., Hübner, S., Haxhikadrija, P., Kretzschmar, T., Müller, T., Wu, J. M. F., Bekfani, T., Franz, M., Wartenberg, M., et al. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.02.016 · Cited by 83
van den Heuvel, N. H. L., van Veen, T. A. B., Lim, B., & Jonsson, M. K. B. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.12.011 · Cited by 88
Zhao, Z., Lan, H., El‐Battrawy, I., Li, X., Buljubasic, F., Sattler, K., Yücel, G., Lang, S., Tiburcy, M., Zimmermann, W., et al. (2018) · Stem Cells International · doi:10.1155/2018/6067096 · Cited by 81
Blazeski, A., Zhu, R., Hunter, D. W., Weinberg, S. H., Boheler, K. R., Zambidis, E. T., & Tung, L. (2012) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2012.07.012 · Cited by 82
Excitation–contraction coupling of human induced pluripotent stem cell-derived cardiomyocytes
Kane, C., Couch, L. S., & Terracciano, C. M. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00059 · Cited by 84
Induced Pluripotent Stem Cell–Derived Cardiomyocytes Provide In Vivo Biological Pacemaker Function
Chauveau, S., Anyukhovsky, E. P., Ben-Ari, M., Naor, S., Jiang, Y., Danilo, P., Rahim, T., Burke, S., Qiu, X., Potapova, I. A., et al. (2017) · Circulation Arrhythmia and Electrophysiology · doi:10.1161/circep.116.004508 · Cited by 73
Self-citationHuman iPSC modeling of heart disease for drug development
Hnatiuk, A. P., Briganti, F., Staudt, D., & Mercola, M. A. (2021) · Cell chemical biology · doi:10.1016/j.chembiol.2021.02.016 · Cited by 81
Blazeski, A., Zhu, R., Hunter, D. W., Weinberg, S. H., Zambidis, E. T., & Tung, L. (2012) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2012.07.013 · Cited by 66
Jung, G., Fajardo, G., Ribeiro, A. J. S., Kooiker, K. B., Coronado, M. J., Zhao, M., Hu, D., Reddy, S., Kodo, K., Sriram, K., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-280982 · Cited by 66
Baldassarre, A. D., Cimetta, E., Bollini, S., Gaggi, G., & Ghinassi, B. (2018) · Cells · doi:10.3390/cells7060048 · Cited by 69
The case for induced pluripotent stem cell‐derived cardiomyocytes in pharmacological screening
Khan, J. M., Lyon, A. R., & Harding, S. E. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02118.x · Cited by 66
Martins, A. M., Vunjak‐Novakovic, G., & Reis, R. L. (2014) · Stem Cell Reviews and Reports · doi:10.1007/s12015-013-9487-7 · Cited by 60
Cardiomyocytes derived from human pluripotent stem cells for drug screening
Zeevi‐Levin, N., Itskovitz‐Eldor, J., & Binah, O. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.01.005 · Cited by 54
Self-citationSugiura, T., Hibino, N., Breuer, C. K., & Shinoka, T. (2016) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-016-0559-z · Cited by 53
Pourrier, M., & Fedida, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020657 · Cited by 53
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Tanaka, A., Yuasa, S., Node, K., & Fukuda, K. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160818894 · Cited by 52
Single-Cell RNA Sequencing of the Cardiovascular System: New Looks for Old Diseases
Chaudhry, F., Isherwood, J., Bawa, T. S., Patel, D. A., Gurdziel, K., Lanfear, D. E., Ruden, D. M., & Levy, P. D. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00173 · Cited by 53
Yang, X., & Papoian, T. (2018) · Journal of Applied Toxicology · doi:10.1002/jat.3611 · Cited by 45
Dekel-Naftali, M., Aviram‐Goldring, A., Litmanovitch, T., Shamash, J., Reznik‐Wolf, H., Laevsky, I., Amit, M., Itskovitz‐Eldor, J., Yung, Y., Hourvitz, A., et al. (2012) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.128 · Cited by 44
Self-citationFunctional microvascularization of human myocardium in vitro
King, O., Cruz-Moreira, D., Sayed, A., Kermani, F., Kit-Anan, W., Sunyovszki, I., Wang, B. X., Downing, B., Fourre, J., Hachim, D., et al. (2022) · Cell Reports Methods · doi:10.1016/j.crmeth.2022.100280 · Cited by 42
Ben-Ari, M., Schick, R., Barad, L., Novak, A., Ben-Ari, E., Lorber, A., Itskovitz‐Eldor, J., Rosen, M. R., Weissman, A., & Binah, O. (2014) · Heart Rhythm · doi:10.1016/j.hrthm.2014.05.037 · Cited by 41
Self-citationSheng, C. C., Amiri‐Kordestani, L., Palmby, T. R., Force, T. L., Hong, C. C., Wu, J. C., Croce, K., Kim, G., & Moslehi, J. J. (2016) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2016.05.008 · Cited by 40
El‐Battrawy, I., Lang, S., Zhao, Z., Akın, İ., Yücel, G., Meister, S., Patocskai, B., Behnes, M., Rudic, B., Tülümen, E., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166143 · Cited by 38
Human Embryonic Stem Cells vs Human Induced Pluripotent Stem Cells for Cardiac Repair
Barad, L., Schick, R., Zeevi‐Levin, N., Itskovitz‐Eldor, J., & Binah, O. (2014) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2014.06.023 · Cited by 36
Self-citationInduced pluripotent stem cell-derived cardiomyocytes as models for genetic cardiovascular disorders
Josowitz, R., Carvajal‐Vergara, X., Lemischka, I. R., & Gelb, B. D. (2011) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e32834598ad · Cited by 34
The Role of Reactive Oxygen Species in In Vitro Cardiac Maturation
Momtahan, N., Crosby, C. O., & Zoldan, J. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.04.005 · Cited by 33
Hallas, T., Eisen, B., Shemer, Y., Jehuda, R. B., Mekies, L. N., Naor, S., Schick, R., Eliyahu, S., Reiter, I., Vlodavsky, E., et al. (2017) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13392 · Cited by 30
Self-citationNovel Insights into Disease Modeling Using Induced Pluripotent Stem Cells
Egashira, T., Yuasa, S., & Fukuda, K. (2013) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b12-00960 · Cited by 30
A Chemical Biology Approach to Myocardial Regeneration
Willems, E., Lanier, M. C., Forte, E., Lo, F., Cashman, J. R., & Mercola, M. A. (2011) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-011-9270-6 · Cited by 29
Martewicz, S., Serena, E., Zatti, S., Keller, G. M., & Elvassore, N. (2017) · Stem Cell Research · doi:10.1016/j.scr.2017.10.011 · Cited by 30
Erñst, P., Bidwell, P. A., Dora, M., Thomas, D. D., & Kamdar, F. D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.986107 · Cited by 26
Narkar, A., Willard, J. M., & Blinova, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23063199 · Cited by 27
hiPSC Modeling of Inherited Cardiomyopathies
Jung, G., & Bernstein, D. (2014) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-014-0320-7 · Cited by 27
Shinozawa, T., Imahashi, K., Sawada, H., Furukawa, H., & Takami, K. (2012) · SLAS DISCOVERY · doi:10.1177/1087057112449864 · Cited by 25
Endogenous cardiac stem cells for the treatment of heart failure
Fuentes, T., & Kearns‐Jonker, M. (2013) · Stem Cells and Cloning Advances and Applications · doi:10.2147/sccaa.s29221 · Cited by 25
Seki, T., Yuasa, S., Kusumoto, D., Kunitomi, A., Saito, Y., Tohyama, S., Yae, K., Kishino, Y., Okada, M., Hashimoto, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085645 · Cited by 24
Zhi, D., Irvin, M. R., Gu, C. C., Stoddard, A. J., Lorier, R., Matter, A. M., Rao, D. C., Srinivasasainagendra, V., Tiwari, H. K., Turner, A., et al. (2012) · Frontiers in Genetics · doi:10.3389/fgene.2012.00092 · Cited by 24
Zhang, X., & Morad, M. (2015) · Cell Calcium · doi:10.1016/j.ceca.2015.12.002 · Cited by 25
Arrhythmogenic risks of stem cell replacement therapy for cardiovascular diseases
Chen, K., Huang, Y., Singh, R. R., & Wang, Z. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29554 · Cited by 22
Tsume, Y., Drelich, A. J., Smith, D. E., & Amidon, G. L. (2017) · Molecules · doi:10.3390/molecules22081322 · Cited by 21
Matsuda, Y., Takahashi, K., Kamioka, H., & Naruse, K. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.116 · Cited by 20
Segev, H., Fishman, B., Schulman, R., & Itskovitz‐Eldor, J. (2012) · Stem Cells and Development · doi:10.1089/scd.2011.0682 · Cited by 19
Self-citationVascular Potential of Human Pluripotent Stem Cells
Iacobas, I., Vats, A., & Hirschi, K. K. (2010) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.191601 · Cited by 18
Real-time imaging of cellular forces using optical interference
Meek, A. T., Kronenberg, N. M., Morton, A., Liehm, P., Murawski, J., Dalaka, E., Booth, J. H. H., Powis, S. J., & Gather, M. C. (2021) · Nature Communications · doi:10.1038/s41467-021-23734-4 · Cited by 18
iPSC-cardiomyocytes in the preclinical prediction of candidate pharmaceutical toxicity
Lee, T. Y. T., Coles, J. G., & Maynes, J. T. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1308217 · Cited by 18
Zhang, X., & Morad, M. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102244 · Cited by 18
iPSC Therapy for Myocardial Infarction in Large Animal Models: Land of Hope and Dreams
Martínez‐Falguera, D., Egea, O. I., & Gálvez‐Montón, C. (2021) · Biomedicines · doi:10.3390/biomedicines9121836 · Cited by 19
Liu, Q., & Trudeau, M. C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0123951 · Cited by 22
Irradiation strongly reduces tumorigenesis of human induced pluripotent stem cells
Inui, S., Minami, K., Ito, E., Imaizumi, H., Mori, S., Koizumi, M., Fukushima, S., Miyagawa, S., Sawa, Y., & Matsuura∥, N. (2017) · Journal of Radiation Research · doi:10.1093/jrr/rrw124 · Cited by 17
Satsuka, A., & Kanda, Y. (2019) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201020666190628143345 · Cited by 17
Priori, S. G. (2011) · Circulation Research · doi:10.1161/circresaha.111.253724 · Cited by 17
Nakazato, T., Kawamura, T., Uemura, T., Liu, L., Li, J., Sasai, M., Harada, A., Ito, E., Iseoka, H., Toda, K., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.03.012 · Cited by 17
Krishnamoorthi, M. K., Sarig, U., Baruch, L., Ting, S., Reuveny, S., Oh, S., Goldfracht, I., Gepstein, L., Venkatraman, S. S., Tan, L. P., et al. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00310 · Cited by 16
Germanguz, I., Shtrichman, R., Osenberg, S., Ziskind, A., Novak, A., Domev, H., Laevsky, I., Jacob‐Hirsch, J., Feiler, Y., Rechavi, G., et al. (2013) · Stem Cells and Development · doi:10.1089/scd.2013.0206 · Cited by 16
Self-citationHuman cardiomyogenesis and the need for systems biology analysis
Young, D. A., DeQuach, J. A., & Christman, K. L. (2010) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.141 · Cited by 16
Lin, Y., Ni, X., Zhang, J., Ou, C., He, X., Dai, W., Chen, X., & Chen, M. (2020) · Bioscience Reports · doi:10.1042/bsr20193369 · Cited by 16
Becker, B. V., Seeger, T., Beiert, T., Antwerpen, M. H., Palnek, A., Port, M., & Ullmann, R. (2018) · Health Physics · doi:10.1097/hp.0000000000000817 · Cited by 16
Gene expression changes in human iPSC-derived cardiomyocytes after X-ray irradiation
Becker, B. V., Majewski, M., Abend, M., Palnek, A., Nestler, K., Port, M., & Ullmann, R. (2018) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1516908 · Cited by 15
Wang, H., Xi, Y. T., Zheng, Y., Wang, X., & Cooney, A. J. (2016) · Stem Cell Research · doi:10.1016/j.scr.2016.02.032 · Cited by 15
Matsuzaki, Y., Miyamoto, S., Miyachi, H., Sugiura, T., Reinhardt, J. W., Chang, Y., Zbinden, J. C., Breuer, C. K., & Shinoka, T. (2020) · PLoS ONE · doi:10.1371/journal.pone.0234087 · Cited by 14
Pluripotent Stem Cell Therapy in Ischemic Cardiovascular Disease.
Chao, T., Chen, I., Tseng, S.-Y., & Li, Y. (2014) · PubMed Central · Cited by 14
Recent advancements of human iPSC derived cardiomyocytes in drug screening and tissue regeneration
Huang, Y., Wang, T., Lopez, M. E. U., Hirano, M., Hasan, A., & Shin, S. R. (2020) · Microphysiological Systems · doi:10.21037/mps-20-3 · Cited by 14
Therapeutic potential of perivascular cells from human pluripotent stem cells
Dar, A., & Itskovitz‐Eldor, J. (2013) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1698 · Cited by 11
Self-citationMolecular Approaches in HFpEF: MicroRNAs and iPSC-Derived Cardiomyocytes
Kriegel, A. J., Gartz, M., Afzal, M. Z., de Lange, W. J., Ralphe, J. C., & Strande, J. L. (2016) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-016-9723-z · Cited by 11
Dvinskikh, L., Sparks, H., Brito, L., MacLeod, K. T., Harding, S. E., & Dunsby, C. W. (2023) · Scientific Reports · doi:10.1038/s41598-023-29419-w · Cited by 11
Šarić, T., Halbach, M., Khalil, M., & Er, F. (2013) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.863275 · Cited by 11
Metadata
- Authors
- Germanguz, I., Sedan, O., Zeevi‐Levin, N., Shtrichman, R., Barak, E., Ziskind, A., Eliyahu, S., Meiry, G., Amit, M., Itskovitz‐Eldor, J., & Binah, O.
- Affiliations
- Technion – Israel Institute of Technology (IL)
- Corresponding author
- Binah, Ofer
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2011-01
- Volume
- 15
- Issue
- 1
- Pages
- 38-51
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- PMC
- PMC3822492
- OpenAlex
- W2051945150
- Semantic Scholar
- 78518cbc7679530967d8ad894e244db8b27a0988
- Cited by
- 160
- References
- 31
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 6 · 2021: 10 · 2020: 12 · 2019: 5 · 2018: 12 · 2017: 10 · 2016: 11 · 2015: 15 · 2014: 14 · 2013: 14 · 2012: 17
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Cellular and Molecular Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Israel Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- induced pluripotent stem cells, excitation-contraction coupling, sarcoplasmic reticulum calcium release, ryanodine receptor, calsequestrin, calcium handling, force-frequency relationship, post-rest potentiation, cardiac differentiation, human foreskin fibroblasts, Oct4, SOX2, KLF4, c-Myc, retroviral reprogramming
- MeSH terms
- Kruppel-Like Factor 4, Animals, Caffeine, Calcium, Calsequestrin, Cell Differentiation, Cells, Cultured, Fibroblasts, Fluorescent Antibody Technique, Humans, Male, Myocardial Contraction, RNA, Messenger, Ryanodine, Sarcoplasmic Reticulum, Teratoma, Gene Expression, Proto-Oncogene Proteins c-myc, Mice, SCID, Ryanodine Receptor Calcium Release Channel, Myocytes, Cardiac, Octamer Transcription Factor-3, Mice, Kruppel-Like Transcription Factors, Foreskin, SOXB1 Transcription Factors, Induced Pluripotent Stem Cells
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