The DOI matches its Crossref record; 139 of the 139 references it cites were found in a registry or an index.
Activation and regulation of store‐operated calcium entry
Open accessAbstract
Introduction I CRAC Orais STIM1 STIM2 STIM1, STIM2 and Ca 2+ oscillations TRPCs and SOCE Conclusions The process of store‐operated Ca 2+ entry (SOCE), whereby Ca 2+ influx across the plasma membrane is activated in response to depletion of intracellular Ca 2+ stores in the endoplasmic reticulum (ER), has been under investigation for greater than 25 years; however, only in the past 5 years have we come to understand this mechanism at the molecular level. A surge of recent experimentation indicates that STIM molecules function as Ca 2+ sensors within the ER that, upon Ca 2+ store depletion, rearrange to sites very near to the plasma membrane. At these plasma membrane‐ER junctions, STIM interacts with and activates SOCE channels of the Orai family. The molecular and biophysical data that have led to these findings are discussed in this review, as are several controversies within this rapidly expanding field.
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Cites
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Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1
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Metadata
- Authors
- Smyth, J. T., Hwang, S., Tomita, T., DeHaven, W. I., Mercer, J. C., & Putney, J. W.
- Venue
- Journal of Cellular and Molecular Medicine
- Publisher
- Wiley
- Published
- 2010-10
- Volume
- 14
- Issue
- 10
- Pages
- 2337-2349
- ISSN
- 1582-1838 (ISSN-L)
- 1582-4934
- OpenAlex
- W2091352240
- Cited by
- 288
- References
- 139
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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