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Cited by 105Endoplasmic Reticulum Stress and DiseaseIon Channels and ReceptorsAcute Ischemic Stroke Management

Mechanism of Endoplasmic Reticulum Stress in Cerebral Ischemia

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Han, Yu, Yuan, Mei, Guo, Yi-Sha, Shen, Xin-Ya, Gao, Zhen-Kun, Bi, Xia·2021·Frontiers in Cellular Neuroscience
DOI 10.3389/fncel.2021.704334PMC PMC8365026
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Abstract

Endoplasmic reticulum (ER) is the main organelle for protein synthesis, trafficking and maintaining intracellular Ca 2+ homeostasis. The stress response of ER results from the disruption of ER homeostasis in neurological disorders. Among these disorders, cerebral ischemia is a prevalent reason of death and disability in the world. ER stress stemed from ischemic injury initiates unfolded protein response (UPR) regarded as a protection mechanism. Important, disruption of Ca 2+ homeostasis resulted from cytosolic Ca 2+ overload and depletion of Ca 2+ in the lumen of the ER could be a trigger of ER stress and the misfolded protein synthesis. Brain cells including neurons, glial cells and endothelial cells are involved in the complex pathophysiology of ischemic stroke. This is generally important for protein underfolding, but even more for cytosolic Ca 2+ overload. Mild ER stress promotes cells to break away from danger signals and enter the adaptive procedure with the activation of pro-survival mechanism to rescue ischemic injury, while chronic ER stress generally serves as a detrimental role on nerve cells via triggering diverse pro-apoptotic mechanism. What’s more, the determination of some proteins in UPR during cerebral ischemia to cell fate may have two diametrically opposed results which involves in a specialized set of inflammatory and apoptotic signaling pathways. A reasonable understanding and exploration of the underlying molecular mechanism related to ER stress and cerebral ischemia is a prerequisite for a major breakthrough in stroke treatment in the future. This review focuses on recent findings of the ER stress as well as the progress research of mechanism in ischemic stroke prognosis provide a new treatment idea for recovery of cerebral ischemia.

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Cited by

Sorted by citations

Authors
Han, Y., Yuan, M., Guo, Y.-S., Shen, X.-Y., Gao, Z.-K., & Bi, X.
Affiliations
  • Shanghai University of Sport (CN)
  • Shanghai University of Traditional Chinese Medicine (CN)
  • Shanghai University of Medicine and Health Sciences (CN)
Corresponding author
Bi, Xia
ORCID
Venue
Frontiers in Cellular Neuroscience
Publisher
Frontiers Media SA
Published
2021-08-02
Volume
15
Pages
704334-704334
ISSN
1662-5102 (ISSN-L)
DOI
10.3389/fncel.2021.704334
PMC
PMC8365026
OpenAlex
W3189034134
Cited by
105
References
4
Citations by year
2026: 22 · 2025: 23 · 2024: 19 · 2023: 19 · 2022: 19 · 2021: 3
FWCI
1.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Cellular Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Shanghai Municipal Health Bureau
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Endoplasmic Reticulum Stress and Disease
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
Keywords
endoplasmic reticulum stress, cerebral ischemia, ischemic stroke, unfolded protein response, calcium homeostasis, intracellular calcium overload, protein misfolding, apoptosis, neuroinflammation, stroke treatment

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