The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
12‐Month comorbidity patterns and associated factors in Europe: results from the European Study of the Epidemiology of Mental Disorders (ESEMeD) project
Abstract
Objective: Comorbidity patterns of 12‐month mood, anxiety and alcohol disorders and socio‐demographic factors associated with comorbidity were studied among the general population of six European countries. Method: Data were derived from the European Study of the Epidemiology of Mental Disorders (ESEMeD), a cross‐sectional psychiatric epidemiological study in a representative sample of adults aged 18 years or older in Belgium, France, Germany, Italy, the Netherlands and Spain. The diagnostic instrument used was the Composite International Diagnostic Interview (WMH‐CIDI). Data are based on 21 425 completed interviews. Results: In general, high associations were found within the separate anxiety disorders and between mood and anxiety disorders. Lowest comorbidity associations were found for specific phobia and alcohol abuse—the disorders with the least functional disabilities. Comorbidity patterns were consistent cross‐nationally. Associated factors for comorbidity of mood and anxiety disorders were female gender, younger age, lower educational level, higher degree of urbanicity, not living with a partner and unemployment. Only younger people were at greater risk for comorbidity of alcohol disorder with mood, anxiety disorders or both. Conclusion: High levels of comorbidity are found in the general population. Comorbidity is more common in specific groups. To reduce psychiatric burden, early intervention in populations with a primary disorder is important to prevent comorbidity.
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“Conversely, among individuals with a lifetime drug use disorder, 28.3% also had an anxiety disorder, 26.4% had a mood disorder, and 6.8% had schizophrenia.”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [125]
In the citing paper
“and that in persons with panic disorder was 35.8% (OR=2.9) 125 .”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [125]
In the citing paper
“Analogous findings have been docu mented in other US large epidemiological studies, including the National Comorbidity Survey 126 and the National Epidemiologic Survey on Alcohol and Related Conditions 126,127 , as well as in stud ies from other countries 125- 128 .”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [125]
In the citing paper
“that in people with schizophrenia or schizophreniform disorder was 47.0% (OR=4.6)”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [125]
In the citing paper
“prevalence of SUDs in individuals with a lifetime diagnosis of bi polar disorder was 56.1% (odds ratio, OR=6.6)”
From Substance use disorders: a comprehensive update of classification, epidemiology, neurobiology, clinical aspects, treatment and prevention (2023) · cites this paper as [125]
Citations
Cites
Kessler, R. C. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950010008002 · Cited by 12,370
Self-citationWittchen, H.-U. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90036-1 · Cited by 2,348
Kessler, R. C. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830160031005 · Cited by 2,085
Self-citationThe Structure of Common Mental Disorders
Krueger, R. F. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.10.921 · Cited by 1,881
The ESEMeD/MHEDEA 2000 Investigators, Alonso, J., Angermeyer, M. C., Bernert, S., Bruffaerts, R., Brugha, T. S., Bryson, H., de Girolamo, G., de Graaf, R., Demyttenaere, K., et al. (2004) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0047.2004.00327.x · Cited by 1,825
Self-citation(1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.7.979 · Cited by 1,485 · cited 1×
“Comorbid disorders have different risk-factor profiles compared with pure disorders (12, 13).”
BackgroundSelf-citationWittchen, H.-U., Robins, L. N., Cottler, L. B., Sartorius, N., Burke, J. D., Regier, D., & Trials, P. I. T. M. W. F. (1991) · British Journal of Psychiatry · doi:10.1192/bjp.159.5.645 · Cited by 833
Comorbidity of substance use disorders with mood and anxiety disorders
Merikangas, K. R., Mehta, R. L., Molnar, B. E., Walters, E. E., Swendsen, J. D., Aguilar‐Gaxiola, S., Bijl, R. V., Borges, G. L. G., Caraveo-Anduaga, J. J., DeWit, D. J., et al. (1998) · Addictive Behaviors · doi:10.1016/s0306-4603(98)00076-8 · Cited by 747
Self-citationRoy-Byrne, P. P., Stang, P., Wittchen, H.-U., Ustun, B., Walters, E. E., & Kessler, R. C. (2000) · British Journal of Psychiatry · doi:10.1192/bjp.176.3.229 · Cited by 446
Self-citationde Graaf, R., Bijl, R. V., Smit, F., Vollebergh, W., & Spijker, J. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.620 · Cited by 391
Self-citationBijl, R. V., & Ravelli, A. (2000) · American Journal of Public Health · doi:10.2105/ajph.90.4.602 · Cited by 366
de Graaf, R., Bijl, R. V., Smit, F., Ravelli, A., & Vollebergh, W. (2000) · American Journal of Epidemiology · doi:10.1093/aje/152.11.1039 · Cited by 355
Self-citationMerikangas, K. R., Angst, J., Eaton, W., Canino, G., Rubio-Stipec, M., Wacker, H., Wittchen, H.-U., Andrade, L., Essau, C., Whitaker, A., et al. (1996) · British Journal of Psychiatry · doi:10.1192/s0007125000298425 · Cited by 293 · cited 1×
“Patterns of comorbidity can differ dramatically by gender (15), therefore most results will be stratified by gender.”
BackgroundBIJL, R. V., & RAVELLI, A. (2000) · Psychological Medicine · doi:10.1017/s0033291799001841 · Cited by 265
Wittchen, H.-U. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810050051009 · Cited by 219
Primary prevention of secondary disorders: A proposal and agenda
Kessler, R. C., & Price, R. (1993) · American Journal of Community Psychology · doi:10.1007/bf00942174 · Cited by 217
Self-citationSampling and methods of the European Study of the Epidemiology of Mental Disorders (ESEMeD) project
The ESEMeD/MHEDEA 2000 investigators, Alonso, J., Angermeyer, M. C., Bernert, S., Bruffaerts, R., Brugha, T. S., Bryson, H., de Girolamo, G., de Graaf, R., Demyttenaere, K., et al. (2004) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0047.2004.00326 · Cited by 215
Self-citationThe CIDI-Core Substance Abuse and Dependence Questions: Cross-cultural and Nosological Issues
Cottler, L. B., Robins, L. N., Grant, B. F., BLAINE, J. D., Towle, L. H., Wïttchen, H., Sartorius, N., & Trial, P. I. T. W. F. (1991) · The British Journal of Psychiatry · doi:10.1192/bjp.159.5.653 · Cited by 215
Andrews, G., Slade, T. N., & Issakidis, C. (2002) · The British Journal of Psychiatry · doi:10.1192/bjp.181.4.306 · Cited by 212
Psychopathology and Attirition in the Epidemiologic Catchment Area Surveys
Eaton, W. W., Anthony, J. C., Tepper, S., & Dryman, A. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116399 · Cited by 211
de Graaf, R., Bijl, R. V., Spijker, J., Beekman, A. T. F., & Vollebergh, W. (2003) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/s00127-003-0597-4 · Cited by 203
Self-citationTextbook in psychiatric epidemiology
Dunn, J. R. (1996) · Health & Place · doi:10.1016/1353-8292(96)86838-9 · Cited by 182
Critical Issues in the Evaluation of Comorbidity of Psychiatric Disorders
Wïttchen, H. (1996) · The British Journal of Psychiatry · doi:10.1192/s000712500029836x · Cited by 172
Anxiety Disorders: Similarities and Differences of Comorbidity in Treated and Untreated Groups
Wïttchen, H., Essau, C. A., & Krieg, J.-C. (1991) · The British Journal of Psychiatry · doi:10.1192/s0007125000296219 · Cited by 117
FARMER, A. E. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800240038006 · Cited by 111
Alonso, J., Ferrer, M., Romera, B., Vilagut, G., Angermeyer, M. C., Bernert, S., Brugha, T. S., Taub, N. A., Mccolgen, Z., de Girolamo, G., et al. (2002) · International Journal of Methods in Psychiatric Research · doi:10.1002/mpr.123 · Cited by 111
Self-citationOutcome of panic and depression in a seven‐year follow‐up: results of the Zurich study
Volirath, M., & Angst, J. (1989) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1989.tb03031.x · Cited by 109
Kessler, R. C. (1999) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1999.tb05378.x · Cited by 106
Self-citationLifetime Comorbidity of Panic Attacks and Major Depression in a Population-Based Study
Andrade, L. H., Eaton, W. W., & Chilcoat, H. D. (1994) · The British Journal of Psychiatry · doi:10.1192/bjp.165.3.363 · Cited by 89
de Graaf, R., Bijl, R. V., ten Have, M., Beekman, A., & Vollebergh, W. (2004) · Acta Psychiatrica Scandinavica · doi:10.1046/j.0001-690x.2003.00222.x · Cited by 82
Self-citationAnxiety and depression in a community sample: The influence of comorbidity on social functioning
Hecht, H., Zerssen, D. V., & Wïttchen, H. (1990) · Journal of Affective Disorders · doi:10.1016/0165-0327(90)90070-o · Cited by 71
Critical issues in the evaluation of comorbidity
Wïttchen, H. (1996) · Max Planck Institute for Plasma Physics · Cited by 53
Lépine, J., Wïttchen, H., & Essau, C. A. (1993) · Max Planck Institute for Plasma Physics · Cited by 44
Self-citationThe Structure and Stability of Common Mental Disorders: The NEMESIS Study
Vollebergh, W. A. M., Iedema, J., Bijl, R. V., de Graaf, R., Smit, F., & Ormel, J. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.6.597 · Cited by 6
Self-citationAlonso, J., Angermeyer, M. C., Brugha, S., de Girolamo, G., de Graaf, R., Demyttenaere, K., Gasquet, N. V., Haro, J. M., Katz, S. J., Kessler, R. C., et al. (2003) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.1002/mpr.153 · Cited by 4
Research works printed but not linked: 2
- Ravelli A, 1998, Comorbiditeit van psychiatrische stoornissen in de Nederlandse bevolking; resultaten van de Nederlandse Mental Health Survey and Incidence Study (NEMESIS), Tijdschr Psychiatrie, 40, 531
- Wacker HR, 1990, Psychiatry: a world perspective
Cited by
Sorted by citations
Prevalence of antenatal and postnatal anxiety: Systematic review and meta-analysis
Dennis, C., Falah‐Hassani, K., & Shiri, R. (2017) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.116.187179 · Cited by 1,692
“68 Despite improvements in treatment, anxiety remains undetected and untreated in the general population 72 and in perinatal women.”
BackgroundLai, H. M. X., Cleary, M., Sitharthan, T., & Hunt, G. E. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.05.031 · Cited by 941
Kessler, R. C., Chiu, W. T., Jin, R., Ruscio, A. M., Shear, K., & Walters, E. E. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.4.415 · Cited by 795
Self-citationTreatment of anxiety disorders
Bandelow, B., Michaelis, S., & Wedekind, D. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.2/bbandelow · Cited by 811
Alonso, J., Angermeyer, M. C., & Lépine, J. P. (2004) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0047.2004.00325.x · Cited by 758
Self-citation
Metadata
- Authors
- The ESEMeD/MHEDEA 2000 investigators, Alonso, J., Angermeyer, M. C., Bernert, S., Bruffaerts, R., Brugha, T. S., Bryson, H., de Girolamo, G., de Graaf, R., Demyttenaere, K., Gasquet, I., Haro, J. M., Katz, S. J., Kessler, R. C., Kovess, V., Lépine, J. P., Ormel, J., Polidori, G., Russo, L. J., Vilagut, G., Almansa, J., Arbabzadeh‐Bouchez, S., Autonell, J., Bernal, M., Buist‐Bouwman, M. A., Codony, M., Domingo‐Salvany, A., Ferrer, M., Joo, S. S., Martínez‐Alonso, M., Matschinger, H., Mazzi, F., Morgan, Z., Morosini, P., Palacín, C., Romera, B., Taub, N., & Vollebergh, W. A. M.
- Affiliations
- University of Leicester (GB)
- Leipzig University (DE)
- KU Leuven (BE)
- GlaxoSmithKline (United Kingdom) (GB)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- Hôpital Paul-Brousse (FR)
- Universitat de Barcelona (ES)
- Harvard University (US)
- Mutuelle Générale de l'Éducation Nationale (FR)
- University of Groningen (NL)
- Istituto Superiore di Sanità (IT)
- Institut Municipal d'Assistència Sanitària (ES)
- Assistance Publique – Hôpitaux de Paris (FR)
- Trimbos Institute (NL)
- University of Modena and Reggio Emilia (IT)
- ORCID
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 2004-06
- Volume
- 109
- Issue
- s420
- Pages
- 28-37
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W1978533844
- Cited by
- 242
- References
- 35
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 8 · 2019: 7 · 2018: 10 · 2017: 15 · 2016: 9 · 2015: 12 · 2014: 23 · 2013: 14 · 2012: 12
- FWCI
- 21.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- GlaxoSmithKline
- European Commission
- Instituto de Salud Carlos III
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- psychiatric comorbidity, mood disorders, anxiety disorders, alcoholism, specific phobia, alcohol abuse, sociodemographic risk factors, cross-national comparison, mental health burden, early intervention
- MeSH terms
- Adolescent, Adult, Aged, Alcoholism, Anxiety, Cross-Sectional Studies, Demography, Europe, Female, Humans, International Cooperation, Male, Middle Aged, Psychology, Comorbidity, Prevalence, Mood Disorders
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