Stereology: the fast lane between neuroanatomy and brain function or still only a tightrope?
Abstract
Precise and unbiased quantitation of the key element of nervous tissue has solved some long-standing problems in neuroscience and the new stereological methods are now very efficient tools for experimental testing of new (and old!) ideas and concepts. Technically, the "zipless" combination of new stereological methods with certain essential principles for observation and recognition is only beginning to be made.
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The sampling scheme was systematically random and based on stereological unbiased techniques.
“Following a systematically random scheme and based on stereological unbiased techniques, five 50-m-thick sections were selected, taken at equally spaced intervals (3 mm) along the entire length of the EC on each brain (Gundersen, 1992;West, 1993).”
From Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease (1996) · cites this paper as Gundersen, 1992
Cites
The efficiency of systematic sampling in stereology and its prediction *
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Self-citationWest, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994 · see citing works
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Self-citationThe unbiased estimation of number and sizes of arbitrary particles using the disector
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Self-citationGundersen, H. J. G. (1986) · PubMed · Cited by 1,659 · see citing works
Self-citationStereology of arbitrary particles*
Gundersen, H. J. G. (1986) · Journal of Microscopy · doi:10.1111/j.1365-2818.1986.tb02764.x · Cited by 1,444 · see citing works
Self-citationUnbiased stereological estimation of the number of neurons in the human hippocampus
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Self-citationBendtsen, T. F., & Nyengaard, J. R. (1989) · Journal of Microscopy · doi:10.1111/j.1365-2818.1989.tb01470.x · Cited by 47 · see citing works
Estimating the total number of lymphatic valves in infant lungs with the fractionator
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The practical use of the fractionator in glomerular counting
Nyengaard, J. R., & Bendtsen, T. F. (1989) · Scopus (Elsevier) · Cited by 4 · see citing works
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West, M. J., Slomianka, L., & Gundersen, H. J. G. (1991) · The Anatomical Record · doi:10.1002/ar.1092310411 · Cited by 2,994 · see citing works
Self-citationProfound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
Gómez-Isla, T., Price, J. L., McKeel Jr., D. W., Morris, J. C., Growdon, J. H., & Hyman, B. T. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-14-04491.1996 · Cited by 1,796 · see citing works
“Following a systematically random scheme and based on stereological unbiased techniques, five 50-mm-thick sections were selected, taken at equally spaced intervals (3 mm) along the entire length of the EC on each brain (Gundersen, 1992; West, 1993).”
MethodMinocycline Enhances MPTP Toxicity to Dopaminergic Neurons
Yang, L., Sugama, S., Chirichigno, J. W., Gregorio, J., Lorenzl, S., Shin, D. H., Browne, S. E., Shimizu, Y., Joh, T. H., Beal, M. F., et al. (2003) · Journal of Neuroscience Research · doi:10.1002/jnr.10709 · Cited by 158 · see citing works
- Authors
- Gundersen, H. J. G.
- Affiliations
- Aarhus University (DK)
- Corresponding author
- Gundersen, H. J. G.
- Venue
- Acta Neurologica Scandinavica
- Publisher
- Hindawi Limited
- Published
- 1992-03
- Volume
- 85
- Issue
- S137
- Pages
- 8-13
- ISSN
- 0001-6314 (ISSN-L)
- 1600-0404
- OpenAlex
- W2083770233
- Cited by
- 81
- References
- 16
- Citations by year
- 2020: 2 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 3 · 2013: 2 · 2012: 1
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Neurologica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Mathematics › Applied Mathematics › Point processes and geometric inequalities
- Health Sciences › Medicine › Anatomy › Medical and Biological Sciences
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
- Keywords
- stereology, quantitative neuroanatomy, brain function, nervous tissue
- MeSH terms
- Central Nervous System, Female, Humans, Male, Neurosciences, Neurotransmitter Agents
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