Minocycline Enhances MPTP Toxicity to Dopaminergic Neurons
Open accessAbstract
Minocycline has been shown previously to have beneficial effects against ischemia in rats as well as neuroprotective properties against excitotoxic damage in vitro, nigral cell loss via 6-hydroxydopamine, and to prolong the life-span of transgenic mouse models of Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). We investigated whether minocycline would protect against toxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a toxin that selectively destroys nigrostriatal dopaminergic (DA) neurons and produces a clinical state similar to Parkinson's disease (PD) in rodents and primates. We found that although minocycline inhibited microglial activation, it significantly exacerbated MPTP-induced damage to DA neurons. We present evidence suggesting that this effect may be due to inhibition of DA and 1-methyl-4-phenylpridium (MPP+) uptake into striatal vesicles.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Minocycline administration to MPTP-treated rodents and primates causes enhanced toxicity and disease exacerbation.
“Indeed, an enhanced toxicity has been reported upon minocycline administration to MPTP-treated rodents and primates, resulting in disease exacerbation [275,276].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [275]
Cites
Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis
Langston, J. W., Ballard, P., Tetrud, J. W., & Irwin, I. (1983) · Science · doi:10.1126/science.6823561 · Cited by 4,914 · see citing works
Nicklas, W. J., Vyas, I. L., & Heikkila, R. E. (1985) · Life Sciences · doi:10.1016/0024-3205(85)90146-8 · Cited by 1,266 · see citing works
Javitch, J. A., D’Amato, R. J., Strittmatter, S. M., & Snyder, S. H. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.7.2173 · Cited by 1,264 · see citing works
Wu, D. C., Jackson-Lewis, V., Vila, M., Tieu, K., Teismann, P., Vadseth, C., Choi, D.-K., Ischiropoulos, H., & Przedborski, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-05-01763.2002 · Cited by 1,183 · see citing works
Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase
Chiba, K., Trevor, A. J., & Castagnoli, N. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)91293-2 · Cited by 1,098 · see citing works
Zhu, S., Stavrovskaya, I. G., Drozda, M., Kim, B. Y. S., Ona, V. O., Li, M., Sarang, S. S., Liu, A. S., Hartley, D. M., Wu, D. C., et al. (2002) · Nature · doi:10.1038/417074a · Cited by 1,071 · see citing works
Chen, M., Ona, V. O., Li, M., Ferrante, R. J., Fink, K., Zhu, S., Bian, J., Guo, L., Farrell, L. A., Hersch, S. M., et al. (2000) · Nature Medicine · doi:10.1038/77528 · Cited by 1,056 · see citing works
Liberatore, G. T., Jackson-Lewis, V., Vukosavic, S., Mandir, A. S., Vila, M., McAuliffe, W. G., Dawson, V. L., Dawson, T. M., & Przedborski, S. (1999) · Nature Medicine · doi:10.1038/70978 · Cited by 1,046 · cited 2× · see citing works
“…with the observation that tyrosinehydroxylase (TH)-immunoreactive SNpc cell bodies in mice lacking the iNOS gene are relatively resistant to MPTP toxicity (Liberatore et al., 1999), suggest that glial activation and the subsequent release of nitric oxide (NO) may contribute to MPTP toxicity.”
BackgroundYrjänheikki, J., Kauppinen, T. M., Keinänen, R., Goldsteins, G., Chan, P. H., & Koıstınaho, J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13496 · Cited by 1,040 · see citing works
Dopaminergic Neurotoxicity of 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine in Mice
Heikkila, R. E., Hess, A., & Duvoisin, R. C. (1984) · Science · doi:10.1126/science.6610213 · Cited by 1,010 · see citing works
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
Yrjänheikki, J., Keinänen, R., Pellikka, M., Hökfelt, T., & Koistinaho, J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15769 · Cited by 1,006 · see citing works
Tikka, T., Fiebich, B. L., Goldsteins, G., Keinänen, R., & Koistinaho, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02580.2001 · Cited by 958 · see citing works
Du, Y., Ma, Z., Lin, S., Dodel, R. C., Gao, F., Bales, K. R., Triarhou, L. C., Chernet, E., Perry, K. W., Nelson, D. L. G., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251341998 · Cited by 789 · see citing works
Xu, J., Kao, S., Lee, F. J. S., Song, W., Jin, L., & Yankner, B. A. (2002) · Nature Medicine · doi:10.1038/nm0602-600 · Cited by 757 · see citing works
Volles, M. J., Lee, S., Rochet, J., Shtilerman, M. D., Ding, T. T., Kessler, J. C., & Lansbury, P. T. (2001) · Biochemistry · doi:10.1021/bi0102398 · Cited by 682 · see citing works
Berman, S. B., & Hastings, T. G. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731127.x · Cited by 664 · see citing works
A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter
Liu, Y. (1992) · Cell · doi:10.1016/0092-8674(92)90425-c · Cited by 589 · see citing works
Chen, D., Endres, R. L., Erickson, C. A., Weis, K. F., McGregor, M. W., Kawaoka, Y., & Payne, L. G. (2000) · Nature Medicine · doi:10.1038/80538 · Cited by 547 · see citing works
A consideration of neural counting methods
Coggeshall, R. E. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90339-a · Cited by 540 · see citing works
Changes in cytokines and neurotrophins in Parkinson’s disease
Nagatsu, T., Mogi, M., Ichinose, H., & Togari, A. (2000) · Springer eBooks · doi:10.1007/978-3-7091-6301-6_19 · Cited by 507 · see citing works
Microglia in degenerative neurological disease
McGeer, P. L., Kawamata, T., Walker, D. G., Akiyama, H., Tooyama, I., & McGeer, E. G. (1993) · Glia · doi:10.1002/glia.440070114 · Cited by 500 · see citing works
A novel mechanism of action of tetracyclines: Effects on nitric oxide synthases
Amin, A. R., Attur, M. G., Thakker, G. D., Patel, P. D., Vyas, P., Patel, R. N., Patel, I. R., & Abramson, S. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.14014 · Cited by 474 · see citing works
Takahashi, N., Miner, L. L., Sora, I., Ujike, H., Revay, R. S., Kostić, V., Jackson-Lewis, V. R., Przedborski, S., & Uhl, G. R. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9938 · Cited by 429 · see citing works
Kurkowska‐Jastrzębska, I., Wrońska, A., Kohutnicka, M., Członkowski, A., & Członkowska, A. (1999) · Experimental Neurology · doi:10.1006/exnr.1998.6993 · Cited by 379 · see citing works
Creatine and Cyclocreatine Attenuate MPTP Neurotoxicity
Matthews, R. T., Ferrante, R. J., Klivènyi, P., Yang, L., Klein, A., Mueller, G., Kaddurah-Daouk, R. F., & Beal, M. F. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7049 · Cited by 374 · see citing works
He, Y., Appel, S. H., & Le, W. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02681-6 · Cited by 350 · see citing works
Midbrain dopaminergic neurons (nuclei A8, A9, and A10): Three‐dimensional reconstruction in the rat
German, D. C., & Manaye, K. F. (1993) · The Journal of Comparative Neurology · doi:10.1002/cne.903310302 · Cited by 255 · see citing works
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyride Neurotoxicity Is Attenuated in Mice Overexpressing Bcl-2
Yang, L., Matthews, R. T., Schulz, J. B., Klockgether, T., Liao, A., Martinou, J., Penney, J. B., Hyman, B. T., & Beal, M. F. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08145.1998 · Cited by 199 · see citing works
Increased MPTP Neurotoxicity in Vesicular Monoamine Transporter 2 Heterozygote Knockout Mice
Gainetdinov, R. R., Fumagalli, F., Wang, Y., Jones, S. R., Levey, A. I., Miller, G. W., & Caron, M. G. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70051973.x · Cited by 178 · see citing works
Selective dopaminergic vulnerability: 3,4-dihydroxyphenylacetaldehyde targets mitochondria
Kristal, B. S. (2001) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(01)00484-1 · Cited by 134 · see citing works
Staal, R. G. W., & Sonsalla, P. K. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39240-7 · Cited by 98 · see citing works
Increased vulnerability of dopaminergic neurons in MPTP‐lesioned interleukin‐6 deficient mice
Bolin, L., Strycharska-Orczyk, I., Murray, R., Langston, J., & Monte, D. D. D. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01131.x · Cited by 95 · see citing works
Role of TNF-α Receptors in Mice Intoxicated with the Parkinsonian Toxin MPTP
Rousselet, E., Callebert, J., Parain, K., Joubert, C., Hunot, S., Hartmann, A., Jacque, C., Pérez-Díaz, F., Cohen‐Salmon, C., Launay, J., et al. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7960 · Cited by 90 · see citing works
Stereology: the fast lane between neuroanatomy and brain function or still only a tightrope?
Gundersen, H. J. G. (1992) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1992.tb05032.x · Cited by 81 · see citing works
Volpe, B. T., Wildmann, J., & Altar, C. A. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00424-7 · Cited by 70 · see citing works
Selective MPP+ uptake into synaptic dopamine vesicles: possible involvement in MPTP neurotoxicity
Zompo, M. D., Piccardi, M. P., Ruiu, S., Quartu, M., GESSA, G. L., & Vaccari, A. (1993) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1993.tb13584.x · Cited by 69 · see citing works
Staal, R. G. W., Hogan, K. A., Liang, C., German, D. C., & Sonsalla, P. K. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39239-0 · Cited by 65 · see citing works
Histological and temporal characteristics of nigral transneuronal degeneration after striatal injury
DeGiorgio, L. A., Dibinis, C., Milner, T. A., Saji, M., & Volpe, B. T. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00247-9 · Cited by 42 · see citing works
German, D. C., Liang, C., Manaye, K. F., Lane, K. B., & Sonsalla, P. K. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00385-7 · Cited by 41 · see citing works
Characteristics of Dopaminergic Neurotoxicity Produced by MPTP and Methamphetaminea
Sonsalla, P. K., Giovanni, A., Sieber, B.-A., Donne, K. T. D., & Manzino, L. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb24542.x · Cited by 38 · see citing works
Weiser, M. J., Baker, H. A., Wessel, T., & Joh, T. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-08-03472.1993 · Cited by 36 · see citing works
Albers, D. S., Zeevalk, G. D., & Sonsalla, P. K. (1996) · Brain Research · doi:10.1016/0006-8993(96)00135-7 · Cited by 35 · see citing works
Volpe, B. T., Blau, A. D., Wessel, T. C., & Saji, M. (1995) · Neurobiology of Disease · doi:10.1006/nbdi.1995.0012 · Cited by 28 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease
Turner, M. D., Nedjai, B., Hurst, T. P., & Pennington, D. J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.05.014 · Cited by 2,186 · see citing works
Neuroinflammation in Parkinson’s disease: A target for neuroprotection?
Hirsch, E. C., & Hunot, S. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70062-6 · Cited by 1,984 · see citing works
Oxidative stress in neurodegeneration: Cause or consequence?
Andersen, J. K. (2004) · Nature Medicine · doi:10.1038/nrn1434 · Cited by 1,869 · see citing works
Tansey, M. G., & Goldberg, M. S. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.11.004 · Cited by 1,045 · see citing works
Minocycline: Far beyond an Antibiotic
Garrido‐Mesa, N., Zarzuelo, A., & Gálvez, J. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12139 · Cited by 935 · see citing works
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
Gordon, P. H., Moore, D. H., Miller, R. G., Florence, J. M., Verheijde, J. L., Doorish, C., Hilton, J. F., Spitalny, G. M., MacArthur, R. B., Mitsumoto, H., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70270-3 · Cited by 649 · see citing works
MPTP Mouse Models of Parkinson’s Disease: An Update
Meredith, G. E., & Rademacher, D. J. (2011) · Journal of Parkinson's Disease · doi:10.3233/jpd-2011-11023 · Cited by 471 · see citing works
The Promise of Minocycline in Neurology
Yong, V. W., Wells, J., Giuliani, F., Casha, S., Power, C., & Metz, L. M. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00937-8 · Cited by 518 · see citing works
The NINDS NET-PD Investigators (2006) · Neurology · doi:10.1212/01.wnl.0000201252.57661.e1 · Cited by 453 · see citing works
Involvement of Interferon-γ in Microglial-Mediated Loss of Dopaminergic Neurons
Mount, M. P., Lira, A., Grimes, D., Smith, P. D., Faucher, S., Slack, R. S., Anisman, H., Hayley, S. P., & Park, D. S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.5321-06.2007 · Cited by 316 · see citing works
Neuroinflammation and oxidative stress: Co-conspirators in the pathology of Parkinson’s disease
Taylor, J. M., Main, B. S., & Crack, P. J. (2013) · Neurochemistry International · doi:10.1016/j.neuint.2012.12.016 · Cited by 303 · see citing works
Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease
Collins, L. M., Toulouse, A., Connor, T. J., & Nolan, Y. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.01.028 · Cited by 275 · see citing works
The influence of microglia on the pathogenesis of Parkinson's disease
Long-Smith, C. M., Sullivan, A. M., & Nolan, Y. M. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.08.001 · Cited by 296 · see citing works
Prospects for Minocycline Neuroprotection
Plane, J. M., Shen, Y., Pleasure, D., & Deng, W. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.191 · Cited by 276 · see citing works
Sriram, K., Miller, D. B., & O'Callaghan, J. P. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03566.x · Cited by 242 · see citing works
Bye, N., Habgood, M. D., Callaway, J. K., Malakooti, N., Potter, A., Kossmann, T., & Morganti-Kossmann, M. C. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.10.013 · Cited by 239 · see citing works
Sánchez-Guajardo, V., Barnum, C. J., Tansey, M. G., & Romero‐Ramos, M. (2013) · ASN NEURO · doi:10.1042/an20120066 · Cited by 237 · see citing works
Gut microbiota: Implications in Parkinson's disease
Parashar, A., & Malairaman, U. (2017) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2017.02.002 · Cited by 231 · see citing works
Sriram, K., Matheson, J. M., Benkovic, S. A., Miller, D. B., Luster, M. I., & O'Callaghan, J. P. (2006) · The FASEB Journal · doi:10.1096/fj.05-5106com · Cited by 224 · see citing works
Experimental therapeutics in transgenic mouse models of Huntington's disease
Beal, M. F., & Ferrante, R. J. (2004) · Nature reviews. Neuroscience · doi:10.1038/nrn1386 · Cited by 224 · see citing works
Neuroprotection by tetracyclines
Domercq, M., & Matute, C. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.10.001 · Cited by 205 · see citing works
Critical data‐based re‐evaluation of minocycline as a putative specific microglia inhibitor
Möller, T., Bard, F., Bhattacharya, A., Biber, K. P. H., Campbell, B., Dale, E., Eder, C., Gan, L., Garden, G. A., Hughes, Z. A., et al. (2016) · Glia · doi:10.1002/glia.23007 · Cited by 192 · see citing works
Deleterious Effects of Minocycline in Animal Models of Parkinson’s Disease and Huntington’s Disease
Diguet, E., Fernagut, P., Wei, X., Du, Y., Rouland, R., Gross, C., Bezard, E., & Tison, F. (2004) · European Journal of Neuroscience · doi:10.1111/j.0953-816x.2004.03372.x · Cited by 189 · see citing works
Minocycline worsens hypoxic-ischemic brain injury in a neonatal mouse model
Tsuji, M., Wilson, M. A., Lange, M. S., & Johnston, M. V. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.01.011 · Cited by 181 · see citing works
Nikodémová, M., Duncan, I. D., & Watters, J. J. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03520.x · Cited by 176 · see citing works
A Pilot Clinical Trial of Creatine and Minocycline in Early Parkinson Disease
Ninds Net-Pd Investigators (2008) · Clinical Neuropharmacology · doi:10.1097/wnf.0b013e3181342f32 · Cited by 174 · see citing works
Yang, L., Zhao, K., Calingasan, N. Y., Luo, G., Szeto, H. H., & Beal, M. F. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2445 · Cited by 169 · see citing works
Neural and Immune Mechanisms in the Pathogenesis of Parkinson’s Disease
Blandini, F. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9435-y · Cited by 164 · see citing works
Clinical Potential of Minocycline for Neurodegenerative Disorders
BLUM, D., CHTARTO, A., TENENBAUM, L., BROTCHI, J., & LEVIVIER, M. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.07.012 · Cited by 157 · see citing works
Evaluation of animal models of Parkinson's disease for neuroprotective strategies
Emborg, M. E. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.08.004 · Cited by 156 · see citing works
Neuroprotective effect of nicotine on dopaminergic neurons by anti‐inflammatory action
Park, H.-J., Lee, P. H., Ahn, Y. W., Choi, Y. J., Lee, G., Lee, D., Chung, E. S., & Jin, B. K. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05636.x · Cited by 153 · see citing works
Faust, K., Gehrke, S., Yang, Y., Yang, L., Beal, M. F., & Lu, B. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-109 · Cited by 151 · see citing works
Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke
Matsukawa, N., Yasuhara, T., Hara, K., Xu, L., Maki, M., Yu, G., Kaneko, Y., Ojika, K., Hess, D. C., & Borlongan, C. V. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-126 · Cited by 146 · see citing works
The Promise of Neuroprotective Agents in Parkinson?s Disease
Seidl, S. E., & Potashkin, J. A. (2011) · Frontiers in Neurology · doi:10.3389/fneur.2011.00068 · Cited by 141 · see citing works
Croisier, E., & Graeber, M. B. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0119-z · Cited by 130 · see citing works
Bhalala, U. S., Koehler, R. C., & Kannan, S. (2015) · Frontiers in Pediatrics · doi:10.3389/fped.2014.00144 · Cited by 128 · see citing works
Wang, S., Jing, H., Yang, H., Liu, Z., Guo, H. W., Chai, L., & Hu, L. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.01.042 · Cited by 126 · see citing works
The Potential of Minocycline for Neuroprotection in Human Neurologic Disease
Zemke, D., & Majid, A. (2004) · Clinical Neuropharmacology · doi:10.1097/01.wnf.0000150867.98887.3e · Cited by 125 · see citing works
Doxycycline restrains glia and confers neuroprotection in a 6‐OHDA Parkinson model
Lazzarini, M., Martin, S., Mitkovski, M., Raisman‐Vozari, R., Stühmer, W., & Bel, E. D. (2013) · Glia · doi:10.1002/glia.22496 · Cited by 119 · see citing works
Updates on immunity and inflammation in Parkinson disease pathology
Joshi, N., & Singh, S. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24185 · Cited by 118 · see citing works
Optimal delivery of minocycline to the brain: implication for human studies of acute neuroprotection
Fagan, S. C., Edwards, D. J., Borlongan, C. V., Xu, L., Arora, A., Feuerstein, G., & Hess, D. C. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2003.12.006 · Cited by 117 · see citing works
Gonzalez, J., Egea, J., Godino, M. D. C., Fernández-Gómez, F.-J., Sánchez‐Prieto, J., Gandı́a, L., Garcı́a, A. G., Jordán, J., & Hernández-Guijo, J. M. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05873.x · Cited by 111 · see citing works
Doorduin, J., de Vries, E. F. J., Dierckx, R. A. J. O., & Klein, H. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786549443 · Cited by 107 · see citing works
Tetracycline repurposing in neurodegeneration: focus on Parkinson’s disease
Bortolanza, M., Nascimento, G. C., Socías, S. B., Ploper, D., Chehín, R. N., Raisman‐Vozari, R., & Bel, E. A. D. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1913-1 · Cited by 105 · see citing works
Activated microglia targeting dendrimer–minocycline conjugate as therapeutics for neuroinflammation.
Sharma, R., Kim, S.-Y., Sharma, A., Zhang, Z., Kambhampati, S. P., Kannan, S., & Kannan, R. M. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00569 · Cited by 100 · see citing works
Liu, B. (2006) · The AAPS Journal · doi:10.1208/aapsj080369 · Cited by 100 · see citing works
Rise and fall of minocycline in neuroprotection: need to promote publication of negative results
Diguet, E., Gross, C. E., Tison, F., & Bézard, E. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.016 · Cited by 97 · see citing works
Minocycline in neurodegenerative and psychiatric diseases: An update
Romero‐Miguel, D., Lamanna‐Rama, N., Casquero‐Veiga, M., Gómez‐Rangel, V., Desco, M., & Soto‐Montenegro, M. L. (2020) · European Journal of Neurology · doi:10.1111/ene.14642 · Cited by 95 · see citing works
A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model
Pinzón, A., Marcillo, A. E., Quintana, A., Stamler, S., Bunge, M. B., Bramlett, H. M., & Dietrich, W. D. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.047 · Cited by 95 · see citing works
The Therapeutic Role of Minocycline in Parkinson’s Disease
Cankaya, S., Cankaya, B., Kilic, U., Kilic, E., & Yulug, B. (2019) · Drugs in Context · doi:10.7573/dic.212553 · Cited by 93 · see citing works
Modeling neuroinflammatory pathogenesis of Parkinson’s disease
Barnum, C. J., & Tansey, M. G. (2010) · Progress in brain research · doi:10.1016/s0079-6123(10)84006-3 · Cited by 91 · see citing works
Varesi, A., Campagnoli, L. I. M., Fahmideh, F., Pierella, E., Romeo, M., Ricevuti, G., Nicoletta, M., Chirumbolo, S., & Pascale, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012289 · Cited by 88 · see citing works
Role of microglia in a mouse model of paediatric traumatic brain injury
Chhor, V., Moretti, R., Charpentier, T. L., Sigaut, S., Lebon, S., Schwendimann, L., Oré, M.-V., Zuiani, C., Milan, V., Josserand, J., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.11.001 · Cited by 87 · see citing works
Pathogenesis of α-Synuclein in Parkinson’s Disease: From a Neuron-Glia Crosstalk Perspective
Yi, S., Wang, L.-F., Wang, H., Ho, M., & Zhang, S.-P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314753 · Cited by 66 · see citing works
Meissner, W. G., Hill, M. P., Tison, F., Gross, C. E., & Bézard, E. (2004) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2004.03.003 · Cited by 87 · see citing works
Mitochondrial Inhibition and Oxidative Stress: Reciprocating Players in Neurodegeneration
Zeevalk, G. D., Bernard, L. P., Song, C., Gluck, M. J., & Ehrhart, J. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.1117 · Cited by 87 · see citing works
Interrupting apoptosis in neurodegenerative disease: potential for effective therapy?
Waldmeier, P. C., & Tatton, W. G. (2004) · Drug Discovery Today · doi:10.1016/s1359-6446(03)03000-9 · Cited by 85 · see citing works
Yokoyama, H., Kuroiwa, H., Yano, R., & Araki, T. (2008) · Neurological Sciences · doi:10.1007/s10072-008-0986-2 · Cited by 85 · see citing works
Bogaerts, V., Theuns, J., & Broeckhoven, C. V. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00342.x · Cited by 86 · see citing works
Strategies to Promote Neural Repair and Regeneration After Spinal Cord Injury
Kwon, B. K., Fisher, C. G., Dvorak, M. F., & Tetzlaff, W. (2005) · Spine · doi:10.1097/01.brs.0000175186.17923.87 · Cited by 77 · see citing works
Beier, E. E., Neal, M. P., Alam, G., Edler, M. K., Wu, L., & Richardson, J. R. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.08.009 · Cited by 76 · see citing works
Peripheral Immunity, Immunoaging and Neuroinflammation in Parkinson’s Disease
Kuštrimović, N. Z., Marino, F., & Cosentino, M. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666181009161048 · Cited by 74 · see citing works
Lee, J. H. T., Tigchelaar, S., Liu, J., Stammers, A. T., Streijger, F., Tetzlaff, W., & Kwon, B. K. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.06.018 · Cited by 73 · see citing works
Menalled, L., Patry, M., Ragland, N., Lowden, P. A. S., Goodman, J., Minnich, J., Zahasky, B., Park, L., Leeds, J. M., Howland, D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009793 · Cited by 70 · see citing works
Cronin, A., & Grealy, M. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.10.018 · Cited by 68 · see citing works
Disease modification in Parkinson's disease
Schapira, A. H. V. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00769-0 · Cited by 67 · see citing works
Sugama, S., Wirz, S., Barr, A. M., Conti, B., Bartfai, T., & Shibasaki, T. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.07.020 · Cited by 63 · see citing works
Fernández-Gómez, F.-J., Galindo, M. F., Gómez-Lázaro, M., González-García, C., Ceña, V., Aguirre, N., & Jordán, J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.03.019 · Cited by 59 · see citing works
Remote Neurodegeneration: Multiple Actors for One Play
Viscomi, M. T., & Molinari, M. (2014) · Molecular Neurobiology · doi:10.1007/s12035-013-8629-x · Cited by 57 · see citing works
The matrix metalloproteinase inhibitor IPR-179 has antiseizure and antiepileptogenic effects
Broekaart, D. W. M., Bertran, A., Jia, S., Korotkov, A., Senkov, O., Bongaarts, A., Mills, J. D., Anink, J. J., Seco, J., Baayen, J. C., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138332 · Cited by 59 · see citing works
Neuroinflammation and Parkinson's disease.
Przedborski, S. (2007) · Handbook of Clinical Neurology · doi:10.1016/s0072-9752(07)83026-0 · Cited by 55 · see citing works
Minocycline and intracerebral hemorrhage: influence of injury severity and delay to treatment
Szymanska, A., Biernaskie, J. A., Laidley, D. T., Granter‐Button, S., & Corbett, D. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2005.09.011 · Cited by 56 · see citing works
Baptiste, D. C., Hartwick, A. T. E., Jollimore, C. A. B., Baldridge, W. H., Seigel, G. M., & Kelly, M. E. M. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.001081 · Cited by 55 · see citing works
Minocycline in phenotypic models of Huntington's disease
Bantubungi, K., Jacquard, C., Greco, A., Pintor, A., Chtarto, A., Taï, K., Galas, M., Tenenbaum, L., Déglon, N., Popoli, P., et al. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.017 · Cited by 53 · see citing works
Role of reactive nitrogen and reactive oxygen species against MPTP neurotoxicity in mice
Yokoyama, H., Takagi, S., Watanabe, Y., Kato, H., & Araki, T. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0019-6 · Cited by 52 · see citing works
Kalonia, H., Mishra, J., & Kumar, A. (2012) · Neurotoxicity Research · doi:10.1007/s12640-012-9315-x · Cited by 51 · see citing works
Hamill, C. E., Caudle, W. M., Richardson, J. R., Yuan, H., Pennell, K. D., Greene, J. G., Miller, G. W., & Traynelis, S. F. (2007) · Molecular Pharmacology · doi:10.1124/mol.107.038158 · Cited by 51 · see citing works
Dailah, H. G. (2022) · Molecules · doi:10.3390/molecules27217207 · Cited by 50 · see citing works
Impact of minocycline on neurodegenerative diseases in rodents: a meta-analysis
Li, C., Yuan, K., & Schluesener, H. J. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0040 · Cited by 50 · see citing works
Månsson, R., Hansson, M. J., Morota, S., Uchino, H., Ekdahl, C. T., & Elmér, E. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.09.008 · Cited by 46 · see citing works
Therapy with Minocycline Aggravates Experimental Rabies in Mice
Jackson, A. C., Scott, C. A., Owen, J., Weli, S. C., & Rossiter, J. P. (2007) · Journal of Virology · doi:10.1128/jvi.00323-07 · Cited by 44 · see citing works
Rahmani, M., Negro, S., & Barcia, E. (2022) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2022.106237 · Cited by 42 · see citing works
Paradoxical effects of minocycline in the developing mouse somatosensory cortex
Arnoux, I., Hoshiko, M., Diez, A. S., & Audinat, É. (2013) · Glia · doi:10.1002/glia.22612 · Cited by 39 · see citing works
Kosloski, L. M., Ha, D. M., Hutter-Saunders, J. A. L., Stone, D. K., Pichler, M. R., Reynolds, A. D., Gendelman, H. E., & Mosley, R. L. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06834.x · Cited by 40 · see citing works
Kawasaki, T., Ishihara, K., Ago, Y., Nakamura, S., Itoh, S., Baba, A., & Matsuda, T. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.05.012 · Cited by 40 · see citing works
Therapeutic Strategies for Immune Transformation in Parkinson’s Disease
Saleh, M., Marković, M., Olson, K. E., Gendelman, H. E., & Mosley, R. L. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-223278 · Cited by 40 · see citing works
Challenges of Repurposing Tetracyclines for the Treatment of Alzheimer’s and Parkinson’s Disease
Markulin, I., Matasin, M., Turk, V. E., & Salković-Petrisic, M. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-021-02457-2 · Cited by 36 · see citing works
Pinkernelle, J., Fansa, H., Ebmeyer, U., & Keilhoff, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073422 · Cited by 35 · see citing works
Multiple system atrophy: an update and emerging directions of biomarkers and clinical trials
Liu, M., Wang, Z., & Shang, H. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12269-5 · Cited by 34 · see citing works
Microglial Ion Channels as Potential Targets for Neuroprotection in Parkinson’s Disease
Richardson, J. R., & Hossain, M. M. (2013) · Neural Plasticity · doi:10.1155/2013/587418 · Cited by 34 · see citing works
Minocycline fails to protect cerebellar granular cell cultures against malonate-induced cell death
Fernández-Gómez, F.-J., Gómez-Lázaro, M., Pastor, M. D., Calvo, S., Aguirre, N., Galindo, M. F., & Jordán, J. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.03.019 · Cited by 32 · see citing works
Ferrer‐Martín, R. M., Martín‐Oliva, D., Sierra, A., Carrasco, M., Martín‐Estebané, M., Calvente, R., Martín‐Guerrero, S. M., Marín‐Teva, J. L., Navascués, J., & Cuadros, M. Á. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135238 · Cited by 32 · see citing works
Morota, S., Månsson, R., Hansson, M. J., Kasuya, K., Shimazu, M., Hasegawa, E., Yanagi, S., Omi, A., Uchino, H., & Elmér, E. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.03.036 · Cited by 30 · see citing works
Stefanova, N., Mitschnigg, M., Ghorayeb, I., Diguet, E., Geser, F., Tison, F., Poewe, W. H., & Wenning, G. K. (2004) · Journal of Neuroscience Research · doi:10.1002/jnr.20233 · Cited by 30 · see citing works
Urinary Tract Infection in Parkinson’s Disease
Hogg, E., Frank, S., Oft, J., Benway, B., Rashid, M. H., & Lahiri, S. (2022) · Journal of Parkinson s Disease · doi:10.3233/jpd-213103 · Cited by 28 · see citing works
Lack of evidence of direct mitochondrial involvement in the neuroprotective effect of minocycline
Cornet, S., Spinnewyn, B., Delaflotte, S., Charnet, C., Roubert, V., Favre, C., Hider, H., Chabrier, P. E., & Auguet, M. (2004) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2004.10.039 · Cited by 28 · see citing works
Minocycline treatment prevents cavitation in rats after a cortical devascularizing lesion
Hua, R., & Walz, W. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.072 · Cited by 27 · see citing works
Bennett, N. K., Chmielowski, R., Abdelhamid, D. S., Faig, J. J., Francis, N. L., Baum, J., Pang, Z. P., Uhrich, K. E., & Moghe, P. V. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.10.001 · Cited by 27 · see citing works
Antineuroinflammation of Minocycline in Stroke
Chen, Y., Cai, Z., & Ke, Z. (2017) · The Neurologist · doi:10.1097/nrl.0000000000000136 · Cited by 27 · see citing works
Delivering Minocycline into Brain Endothelial Cells with Liposome-Based Technology
Xing, C., Levchenko, T. S., Guo, S., Stins, M. F., Torchilin, V. P., & Lo, E. H. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.48 · Cited by 26 · see citing works
- Authors
- Yang, L., Sugama, S., Chirichigno, J. W., Gregorio, J., Lorenzl, S., Shin, D. H., Browne, S. E., Shimizu, Y., Joh, T. H., Beal, M. F., & Albers, D. S.
- Affiliations
- Cornell University (US)
- Corresponding author
- Beal, M. Flint
- Venue
- Journal of Neuroscience Research
- Publisher
- Wiley
- Published
- 2003-08-26
- Volume
- 74
- Issue
- 2
- Pages
- 278-285
- ISSN
- 0360-4012 (ISSN-L)
- 1097-4547
- OpenAlex
- W1974800756
- Cited by
- 158
- References
- 43
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 10 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 4 · 2014: 6 · 2013: 12 · 2012: 8
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Journal of Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- KUMeL Repository (Keimyung University) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- minocycline, MPTP-induced neurotoxicity, dopaminergic neurons, Parkinson's disease, neuroprotection, microglial activation, MPP+ uptake, neurotoxicity, neuroinflammation
- MeSH terms
- Animals, Dopamine, Dose-Response Relationship, Drug, Doxycycline, Drug Administration Schedule, Drug Synergism, Gliosis, Male, Mice, Inbred C57BL, Minocycline, Neurons, Substantia Nigra, Synaptic Vesicles, Tetracycline, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 1-Methyl-4-phenylpyridinium, Neostriatum, Microglia, Neuroprotective Agents, Parkinsonian Disorders, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review