Cited by 158Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration MechanismsNuclear Receptors and Signaling

Minocycline Enhances MPTP Toxicity to Dopaminergic Neurons

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Yang, Lichuan, Sugama, Shuei, Chirichigno, Jason W., Gregorio, Jason, Lorenzl, Stefan, Shin, Dong H., Browne, Susan E., Shimizu, Yoshinori +3 more·2003·Journal of Neuroscience Research

Abstract

Minocycline has been shown previously to have beneficial effects against ischemia in rats as well as neuroprotective properties against excitotoxic damage in vitro, nigral cell loss via 6-hydroxydopamine, and to prolong the life-span of transgenic mouse models of Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS). We investigated whether minocycline would protect against toxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a toxin that selectively destroys nigrostriatal dopaminergic (DA) neurons and produces a clinical state similar to Parkinson's disease (PD) in rodents and primates. We found that although minocycline inhibited microglial activation, it significantly exacerbated MPTP-induced damage to DA neurons. We present evidence suggesting that this effect may be due to inhibition of DA and 1-methyl-4-phenylpridium (MPP+) uptake into striatal vesicles.

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Crossref · 10.1002/jnr.10709

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Authors
Yang, L., Sugama, S., Chirichigno, J. W., Gregorio, J., Lorenzl, S., Shin, D. H., Browne, S. E., Shimizu, Y., Joh, T. H., Beal, M. F., & Albers, D. S.
Affiliations
Cornell University (US)
Corresponding author
Beal, M. Flint
Venue
Journal of Neuroscience Research
Publisher
Wiley
Published
2003-08-26
Volume
74
Issue
2
Pages
278-285
ISSN
  • 0360-4012 (ISSN-L)
  • 1097-4547
OpenAlex
W1974800756
Cited by
158
References
43
Citations by year
2026: 3 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 10 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 7 · 2017: 8 · 2016: 7 · 2015: 4 · 2014: 6 · 2013: 12 · 2012: 8
FWCI
8.83
Type
journal article
Language
en
Locations
  • Journal of Neuroscience Research (publishedVersion)
  • PubMed (publishedVersion)
  • KUMeL Repository (Keimyung University) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
minocycline, MPTP-induced neurotoxicity, dopaminergic neurons, Parkinson's disease, neuroprotection, microglial activation, MPP+ uptake, neurotoxicity, neuroinflammation
MeSH terms
Animals, Dopamine, Dose-Response Relationship, Drug, Doxycycline, Drug Administration Schedule, Drug Synergism, Gliosis, Male, Mice, Inbred C57BL, Minocycline, Neurons, Substantia Nigra, Synaptic Vesicles, Tetracycline, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 1-Methyl-4-phenylpyridinium, Neostriatum, Microglia, Neuroprotective Agents, Parkinsonian Disorders, Mice

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