Cited by 56Bipolar Disorder and TreatmentTreatment of Major DepressionSchizophrenia research and treatment

Abrupt lithium discontinuation in manic‐depressive patients

Christodoulou, G. N., Lykouras, E. P.·1982·Acta Psychiatrica Scandinavica

Abstract

Prophylactic lithium was abruptly discontinued (under double‐blind conditions and using placebo) in 18 manic‐depressive patients for 15 days. Following lithium withdrawal tremor of hands, polyuria, general muscular weakness, polydipsia and dryness of mouth were significantly reduced. No withdrawal symptoms were noted. Three patients relapsed within 4 days of lithium discontinuation. The questions arising from these findings are discussed and the possibility of a rebound phenomenon produced by lithium is considered.

Integrity signals

Registry

Crossref · 10.1111/j.1600-0447.1982.tb00852.x

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10 of 10 references verified0 citation errors · 0 not checkable

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  • Antipsychotics that are rapidly eliminated or rapidly dissociated from D2 receptors (e.g., clozapine, quetiapine) have greater risks of rebound when medication is decreased, switched, or discontinued.

    “Antipsychotics rapidly eliminated or rapidly dissociated from the D2 receptors (i.e., clozapine, quetiapine) [161, 162] are known to have greater risks of rebound when medication is decreased, switched, or discontinued [13, 154, 156, 157, 163].”

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Authors
Christodoulou, G. N., & Lykouras, E. P.
Affiliations
National and Kapodistrian University of Athens (GR)
Corresponding author
Christodoulou, G. N.
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
1982-05
Volume
65
Issue
5
Pages
310-314
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
OpenAlex
W2064398453
Cited by
56
References
10
Citations by year
2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
FWCI
2.80
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Psychiatrica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
lithium, abrupt discontinuation, bipolar disorder, relapse
MeSH terms
Adolescent, Adult, Aged, Bipolar Disorder, Double-Blind Method, Female, Humans, Lithium, Male, Middle Aged, Recurrence, Substance Withdrawal Syndrome, Lithium Carbonate

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