Abrupt lithium discontinuation in manic‐depressive patients
Abstract
Prophylactic lithium was abruptly discontinued (under double‐blind conditions and using placebo) in 18 manic‐depressive patients for 15 days. Following lithium withdrawal tremor of hands, polyuria, general muscular weakness, polydipsia and dryness of mouth were significantly reduced. No withdrawal symptoms were noted. Three patients relapsed within 4 days of lithium discontinuation. The questions arising from these findings are discussed and the possibility of a rebound phenomenon produced by lithium is considered.
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Antipsychotics that are rapidly eliminated or rapidly dissociated from D2 receptors (e.g., clozapine, quetiapine) have greater risks of rebound when medication is decreased, switched, or discontinued.
“Antipsychotics rapidly eliminated or rapidly dissociated from the D2 receptors (i.e., clozapine, quetiapine) [161, 162] are known to have greater risks of rebound when medication is decreased, switched, or discontinued [13, 154, 156, 157, 163].”
From Acute and Persistent Withdrawal Syndromes Following Discontinuation of Psychotropic Medications (2020) · cites this paper as [154]
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- Authors
- Christodoulou, G. N., & Lykouras, E. P.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Christodoulou, G. N.
- ORCID
- Christodoulou, G. N.
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 1982-05
- Volume
- 65
- Issue
- 5
- Pages
- 310-314
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2064398453
- Cited by
- 56
- References
- 10
- Citations by year
- 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- lithium, abrupt discontinuation, bipolar disorder, relapse
- MeSH terms
- Adolescent, Adult, Aged, Bipolar Disorder, Double-Blind Method, Female, Humans, Lithium, Male, Middle Aged, Recurrence, Substance Withdrawal Syndrome, Lithium Carbonate
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