Cited by 11Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorParkinson's Disease Mechanisms and Treatments

Changes in mental condition, hyperkinesias and biochemical parameters after withdrawal of chronic neuroleptic treatment

Perényi, A., Frecska, E., Bagdy, G., Révai, K.·1985·Acta Psychiatrica Scandinavica

Abstract

Neuroleptics were withdrawn abruptly from 14 hospitalized chronic schizophrenics. For 12 weeks the patients were observed from the aspect of psychic change and the development of withdrawal dyskinesia. Serum prolactin level, plasma dopamine-beta-hydroxylase activity, cerebrospinal fluid homovanillic acid and norepinephrine levels were measured on the day prior to withdrawal and on day 14 of the study. Psychic deterioration showed no association with any of the tested biochemical parameters. The decrease in the CSF HVA and NE levels of the patients displaying symptoms of withdrawal dyskinesia was significantly smaller than in those displaying no dyskinesia.

Integrity signals

Registry

Crossref · 10.1111/j.1600-0447.1985.tb02636.x

Cites

25 of 25 references verified0 citation errors · 0 not checkable

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  • Motor withdrawal symptoms have a reported incidence of 31%-50% after abrupt FGA withdrawal, following long-term treatment.

    “Motor withdrawal symptoms have a reported incidence of 31%–50% after abrupt FGA withdrawal, following long-term treatment.29–31”

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Authors
Perényi, A., Frecska, E., Bagdy, G., & Révai, K.
Corresponding author
Perényi, A.
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
1985-11
Volume
72
Issue
5
Pages
430-435
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
OpenAlex
W2015374224
Cited by
11
References
27
Citations by year
2021: 2 · 2018: 1 · 2017: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Acta Psychiatrica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Keywords
neuroleptic withdrawal, chronic schizophrenia, hyperkinesia, prolactin, dopamine beta-hydroxylase, homovanillic acid, norepinephrine, cerebrospinal fluid, serum prolactin
MeSH terms
Adult, Mental Disorders, Dopamine beta-Hydroxylase, Dyskinesia, Drug-Induced, Female, Homovanillic Acid, Humans, Male, Norepinephrine, Prolactin, Psychiatric Status Rating Scales, Schizophrenia, Substance Withdrawal Syndrome, Antipsychotic Agents

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