Changes in mental condition, hyperkinesias and biochemical parameters after withdrawal of chronic neuroleptic treatment
Abstract
Neuroleptics were withdrawn abruptly from 14 hospitalized chronic schizophrenics. For 12 weeks the patients were observed from the aspect of psychic change and the development of withdrawal dyskinesia. Serum prolactin level, plasma dopamine-beta-hydroxylase activity, cerebrospinal fluid homovanillic acid and norepinephrine levels were measured on the day prior to withdrawal and on day 14 of the study. Psychic deterioration showed no association with any of the tested biochemical parameters. The decrease in the CSF HVA and NE levels of the patients displaying symptoms of withdrawal dyskinesia was significantly smaller than in those displaying no dyskinesia.
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Motor withdrawal symptoms have a reported incidence of 31%-50% after abrupt FGA withdrawal, following long-term treatment.
“Motor withdrawal symptoms have a reported incidence of 31%–50% after abrupt FGA withdrawal, following long-term treatment.29–31”
From A Method for Tapering Antipsychotic Treatment That May Minimize the Risk of Relapse (2021) · cites this paper as [31]
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A Method for Tapering Antipsychotic Treatment That May Minimize the Risk of Relapse
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Self-citation
- Authors
- Perényi, A., Frecska, E., Bagdy, G., & Révai, K.
- Corresponding author
- Perényi, A.
- ORCID
- Venue
- Acta Psychiatrica Scandinavica
- Publisher
- Wiley
- Published
- 1985-11
- Volume
- 72
- Issue
- 5
- Pages
- 430-435
- ISSN
- 0001-690X (ISSN-L)
- 1600-0447
- OpenAlex
- W2015374224
- Cited by
- 11
- References
- 27
- Citations by year
- 2021: 2 · 2018: 1 · 2017: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Psychiatrica Scandinavica (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- neuroleptic withdrawal, chronic schizophrenia, hyperkinesia, prolactin, dopamine beta-hydroxylase, homovanillic acid, norepinephrine, cerebrospinal fluid, serum prolactin
- MeSH terms
- Adult, Mental Disorders, Dopamine beta-Hydroxylase, Dyskinesia, Drug-Induced, Female, Homovanillic Acid, Humans, Male, Norepinephrine, Prolactin, Psychiatric Status Rating Scales, Schizophrenia, Substance Withdrawal Syndrome, Antipsychotic Agents
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