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Cited by 29Schizophrenia research and treatmentNeurotransmitter Receptor Influence on BehaviorMental Health and Psychiatry

Withdrawal-emergent dyskinesia in patients with schizophrenia during antipsychotic discontinuation

Schultz, Susan K., Miller, Del D., Arndt, Stephan, Ziebell, Steve, Gupta, Sanjay, Andreasen, Nancy C.·1995·Biological Psychiatry
DOI 10.1016/0006-3223(95)00082-8
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Abstract

We examined whether patients exhibiting withdrawal-emergent dyskinesia (WE-D) represent a group vulnerable to subsequent development of tardive dyskinesia (TD). WE-D was defined as moderate abnormal movements during antipsychotic withdrawal in persons without persistent TD. We assessed patients with schizophrenia-spectrum illness participating in withdrawal from antipsychotic medication. Patients with WE-D were compared to those without dyskinesia and to those with persistent TD. Clinical measures included duration of illness and antipsychotic exposure, negative symptoms, and neurologic soft signs. We hypothesized that WE-D patients would not differ from persistent-TD patients across the above variables, but would differ from non-TD patients. Patients without TD significantly differed from persistent TD in duration of illness, medication exposure and neurologic soft signs. WE-D did not differ from TD across these measures. No-TD patients also showed less duration of medication exposure and neurologic soft signs than those with WE-D.

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Crossref · 10.1016/0006-3223(95)00082-8

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  • Motor withdrawal symptoms have a reported incidence of 31%-50% after abrupt FGA withdrawal, following long-term treatment.

    “Motor withdrawal symptoms have a reported incidence of 31%–50% after abrupt FGA withdrawal, following long-term treatment.29–31”

    From A Method for Tapering Antipsychotic Treatment That May Minimize the Risk of Relapse (2021) · cites this paper as [29]

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Authors
Schultz, S. K., Miller, D. D., Arndt, S., Ziebell, S., Gupta, S., & Andreasen, N. C.
Affiliations
University of Iowa (US)
Corresponding author
Schultz, Susan K.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1995-12
Volume
38
Issue
11
Pages
713-719
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/0006-3223(95)00082-8
OpenAlex
W2155742044
Cited by
29
References
26
Citations by year
2023: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 2 · 2015: 1 · 2013: 2
FWCI
0.63
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH 40856, MH-31593, MH-43271, R01MH040856)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
tardive dyskinesia, antipsychotic discontinuation, schizophrenia, antipsychotic withdrawal, negative symptoms, disease duration
MeSH terms
Adolescent, Adult, Dyskinesia, Drug-Induced, Female, Humans, Male, Middle Aged, Movement, Schizophrenia, Schizophrenic Psychology, Substance Withdrawal Syndrome, Antipsychotic Agents

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