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Cited by 202Treatment of Major DepressionCancer survivorship and careTryptophan and brain disorders

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Efficacy and safety of mianserin in the treatment of depression of women with cancer

Costa, D., Mogos, I., Toma, T.·1985·Acta Psychiatrica Scandinavica
DOI 10.1111/j.1600-0447.1985.tb08081.x
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Abstract

ABSTRACTS: Depression is a major complication of cancer. The efficacy and safety of mianserin were evaluated in a randomized placebo‐controlled trial of 73 depressed women with cancer. According to RDC diagnosis, all patients showed situational major depression. Both groups were well matched for cancer localization, clinical stages, Karnofsky scores, duration of depression, baseline values on the Hamilton Depression Rating Scale (HDRS), Zung Self‐Rating Depression Scale (ZSRDS), and Clinical Global Impression of Illness Severity (CGI‐S), and for type of depression, whether dominantly depressive or depressive‐anxious. Between days 7–21, there were significantly fewer dropouts with mianserin (7) than with placebo (15). When compared with placebo, there were significant improvements for mianserin for HDRS on days 7, 21 and 28, for ZSRDS on days 7 and 28, and for CGI‐S on days 7, 14, 21 and 28. According to Clinical Global Impression of Illness Improvement (CGI‐I) there were significantly more responders with mianserin (28) than with placebo (18). The efficacy index for mianserin was significantly greater than for placebo on days 21 and 28. At the end of the trial the scores for HDRS sleep disturbance factor and HDRS anxiety‐somatization factor were significantly reduced for mianserin than for placebo. There were no significant differences in side‐effects between treatment groups. It is concluded that mianserin is superior to placebo in reducing the severity and duration of depression which is present especially in patients with advanced cancer. The fact that side‐effects were not a problem with mianserin and that mianserin treatment was safe when used in association with other anticancer drugs suggests that mianserin can be prescribed routinely for alleviating depression in cancer patients.

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Citations

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Research works printed but not linked: 40

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Metadata

Authors
Costa, D., Mogos, I., & Toma, T.
Affiliations
  • Institutul Oncologic Bucuresti (RO)
  • Institutul Clinic Fundeni (RO)
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
1985-05
Volume
72
Issue
s320
Pages
85-92
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
DOI
10.1111/j.1600-0447.1985.tb08081.x
OpenAlex
W2070095833
Cited by
202
References
2
Citations by year
2026: 2 · 2025: 5 · 2023: 1 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 7 · 2012: 8
FWCI
3.55
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 8149 d)
Locations
  • Acta Psychiatrica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
mianserin, depression, cancer, women, antidepressant efficacy, drug safety, sleep disorders, somatization, treatment discontinuation, advanced cancer
MeSH terms
Adult, Aged, Clinical Trials as Topic, Depression, Dibenzazepines, Female, Humans, Mianserin, Middle Aged, Neoplasms

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