Antidepressants for the treatment of depression in people with cancer
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Antidepressants for the treatment of depression in people with cancer (Review)
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Evidence of enduring effects of conventional psycho- or pharmacotherapy is limited or ambiguous.
“Evidence of enduring effects of conventional psycho-or pharmacotherapy is limited or ambiguous (Akechi et al., 2008;Ostuzzi et al., 2018).”
From Psychedelics for the treatment of depression, anxiety, and existential distress in patients with a terminal illness: a systematic review (2022) · cites this paper as Ostuzzi et al., 2018
The Discussion (page unavailable) says no trials assessed antidepressant follow-up response beyond 12 weeks, supporting limited evidence for enduring effects of pharmacotherapy. The review concerns people with cancer, so it does not establish the broader, unqualified claim about conventional therapy; it does not assess psychotherapy. (LLM, conf=0.85)
Experimental — accuracy not yet measuredThe Cochrane review concluded that the evidence for medications compared with placebo was of low certainty based on the limited number and low quality of studies.
“The Cochrane review concluded that the evidence for medications compared with placebo was of low certainty based on the limited number and low quality of studies.”
From Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update (2023) · cites this paper as [57]
The Quality of the evidence section attributes uncertainty to poor study quality, high risk of bias, and small trials, supporting the stated reasons. But it rates confidence in all main outcomes as “very low,” not “low”; the Certainty of the evidence section also uses “very low.” (LLM, conf=0.88)
Experimental — accuracy not yet measuredA 2018 Cochrane review of antidepressant use in cancer patients with MDD found no difference between antidepressants (as a class) and placebo on symptoms of depression at 6-12 weeks.
“Pharmacologic management was investigated in a 2018 Cochrane review of antidepressant use in cancer patients with MDD and no difference between antidepressants (as a class) and placebo on symptoms of depression at 6-12 weeks was found.57”
From Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update (2023) · cites this paper as [57]
The Main results report no difference between antidepressants as a class and placebo on depressive symptoms at 6–12 weeks, based on very-low-certainty evidence. But the Types of participants section includes people with adjustment disorder, dysthymia, or depressive symptoms without a formal major-depression diagnosis, as well as those with MDD. The cited result therefore is not specific to cancer patients with MDD. (LLM, conf=0.88)
Experimental — accuracy not yet measuredHead-to-head comparisons of selective serotonin reuptake inhibitors versus tricyclic antidepressants showed no difference.
“Also, head-to-head comparisons of selective serotonin reuptake inhibitors versus tricyclic antidepressants showed no difference.57”
From Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update (2023) · cites this paper as [57]
The 2018 Cochrane review found null findings for antidepressant use for MDD in patients with cancer at 6-12 weeks.
“a conclusion informed by the 2018 Cochrane review of null findings for antidepressant use for MDD in patients with cancer at 6-12 weeks, a sufficient interval in pharmacologic trials for effects to be detected.57”
From Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update (2023) · cites this paper as [57]
Psychotherapy is the treatment of choice for depression ahead of pharmacological treatment in these patients due to poor tolerability and drug interactions of antidepressants, similar results between medication and placebo in cancer, and patient preference.
“es el tratamiento de elección en depresión por delante del tratamiento farmacológico, por la mala tolerabilidad e interacciones farmacológicas de los antidepresivos en estos pacientes (27 ,28) , porque se han encontrado resultados similares entre la medicación y el placebo en personas con cáncer (29) , y porque los pacientes, tanto oncológicos como no oncológicos, suelen preferirla a la medicación”
From AVANZACT: protocolo e intervención psicoterapéutica en cáncer avanzado basados en Terapia de Aceptación y Compromiso. (2025) · cites this paper as [30]
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Psychedelics for Psychological and Existential Distress in Palliative and Cancer Care
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IDO1 Is a Therapeutic Target for Pancreatic Cancer–Associated Depression
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Association of Second-generation Antiandrogens With Depression Among Patients With Prostate Cancer
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Acupuncture and acupressure with improved cancer-related depression of retrospective studies
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Research progress on the psychological burden and intervention measures in cancer patients
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Depression in the Medically Ill
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Antidepressant Use and Lung Cancer Risk and Survival: A Meta-analysis of Observational Studies
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A systematic review of pharmacologic treatment efficacy for depression in older patients with cancer
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“In the last two decades, the number of oncological patients treated with antidepressants has increased remarkably, since these patients suffer from depression and psychological stress [5].”
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Psychological Survivorship in Head and Neck Cancer
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Can depressed patients make a decision to request voluntary assisted dying?
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The Interplay of Chronic Stress and Cancer: Pathophysiology and Implications for Integrated Care
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“15 Thus, alternative treatment approaches are needed.”
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- Authors
- Ostuzzi, G., Matcham, F., Dauchy, S., Barbui, C., & Hotopf, M.
- Affiliations
- University of Verona (IT)
- King's College London (GB)
- Institut Gustave Roussy (FR)
- Venue
- Cochrane Database of Systematic Reviews
- Publisher
- Wiley
- Published
- 2018-04-23
- Volume
- 2018
- Issue
- 4
- ISSN
- 1361-6137 (ISSN-L)
- 1465-1858
- OpenAlex
- W2940589604
- Cited by
- 158
- References
- 157
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 44 · 2023: 21 · 2022: 29 · 2021: 18 · 2020: 8 · 2019: 9 · 2018: 2 · 2017: 1 · 2015: 1
- FWCI
- 0.96
- Type
- journal article
- Language
- en
- Update notices
- new_version (2023-03-31)
- Open access
- bronze
- doi.org
- Locations
- Cochrane Database of Systematic Reviews (publishedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0515-10102)
- King's College London
- Evidence Synthesis Programme
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- antidepressants, depression, cancer, cancer-related depression, antidepressant efficacy, antidepressant safety
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