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A twin study of DSM‐III‐R anxiety disorders

Skre, I., Onstad, S., Torgersen, S., Lygren, S., Kringlen, E.·1993·Acta Psychiatrica Scandinavica

Abstract

The prevalence of anxiety disorders was studied in a sample of 20 monozygotic (MZ) and 29 dizygotic (DZ) co‐twins of anxiety disorder probands. A comparison group of co‐twins of 12 MZ and 20 DZ twin probands with other non‐psychotic mental disorders was also studied. All subjects were personally interviewed with the Structured Clinical Interview for DSM‐III‐R Axis I (SCID‐I). Panic disorder was significantly more prevalent in co‐twins of panic probands. Generalized anxiety disorder (GAD) was more prevalent in co‐twins of GAD probands with a history of mood disorder (NS). Post‐traumatic stress disorder was significantly more prevalent in co‐twins of anxiety probands and was more prevalent in MZ than in DZ co‐twins. The prevalences of social and simple phobia were equal in co‐twins of anxiety and comparison probands. For both panic disorder and generalized anxiety disorder the MZ:DZ concordance ratio was more than 2:1. The results support the hypothesis of a genetic contribution in the etiology of panic disorder, generalized anxiety disorder and post‐traumatic stress disorder. The hypothesis that simple and social phobia are mainly caused by environmental experiences was also supported.

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Metadata

Authors
Skre, I., Onstad, S., Torgersen, S., Lygren, S., & Kringlen, E.
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
1993-08
Volume
88
Issue
2
Pages
85-92
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
OpenAlex
W2081568209
Cited by
214
References
2
FWCI
4.80
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: A twin study of DSM‐III‐R anxiety disorders. https://app.cochat.ai/papers/10.1111/j.1600-0447.1993.tb03419.x
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Skre, I., Onstad, S., Torgersen, S., Lygren, S., & Kringlen, E. (1993). A twin study of DSM‐III‐R anxiety disorders. Acta Psychiatrica Scandinavica. https://doi.org/10.1111/j.1600-0447.1993.tb03419.x

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