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Cited by 209Schizophrenia research and treatmentGenetic Associations and EpidemiologyGlobal Cancer Incidence and Screening

The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.

Cancer incidence in patients with schizophrenia and their first‐degree relatives – a meta‐analysis

Catts, V. S., Catts, S. V., O’Toole, B. I., Frost, A. D. J.·2008·Acta Psychiatrica Scandinavica
DOI 10.1111/j.1600-0447.2008.01163.x
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Abstract

Objective: Controversy concerning cancer incidence in schizophrenia exists because of heterogeneous study findings. Method: A meta‐analysis was performed on standardized incidence ratios (SIR) of cancer in patients with schizophrenia and first‐degree relatives and compared with general population samples. Results: The pooled overall cancer incidence in patients was not significantly increased (SIR = 1.05, CI 0.95–1.15). Lung cancer incidence was slightly increased (SIR = 1.31, CI 1.01–1.71), but was reduced after adjusting for smoking prevalence. The incidence of several cancers unrelated to smoking was reduced in patients. Breast cancer rates were significantly increased in female patients. The pooled overall cancer incidence in siblings (SIR = 0.89, CI 0.84–0.94) and parents (SIR = 0.90, CI 0.88–0.93) was significantly reduced. A meta‐regression detected a significant relationship between cancer risk in the general population and relative risk in patients. Conclusion: The meta‐analysis aided exploration of inconsistent study findings. There is a discrepancy between cancer risk exposure and cancer incidence in schizophrenia consistent with a protective effect.

Overview

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Crossref · 10.1111/j.1600-0447.2008.01163.x

Cites

62 of 62 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 63 references

Research works printed but not linked: 7

  1. Cochrane Collaboration, 2006, Review manager (RevMan) [Computer program]
  2. Nakane Y, 1986, Psychiatric case registers in public health, 240
  3. Dupont A, 1986, Psychiatric case registers in public health, 229
  4. Mackay J, 2006, The cancer atlas
  5. Higgins JPT, 2006, Skewed data 8.5.2.11, in Cochrane handbook for systematic reviews of interventions 4.2.6 [Updated September 2006]
  6. Catts VS, 2007, No in vitro anti‐cancer effect of antipsychotic drugs at doses used in the psychiatric clinic, Schizophr Bull, 33, 230
  7. Mortensen PB, 1987, Cancerdiagnostic og autopsifrekvens blandt schizofrene patienter, Ugeskr Laeger, 149, 1973

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Metadata

Authors
Catts, V. S., Catts, S. V., O’Toole, B. I., & Frost, A. D. J.
Affiliations
  • The University of Queensland (AU)
  • The University of Sydney (AU)
  • Royal Brisbane and Women's Hospital (AU)
Corresponding author
  • Catts, V. S.
  • Catts, S. V.
ORCID
Venue
Acta Psychiatrica Scandinavica
Publisher
Wiley
Published
2008-03-10
Volume
117
Issue
5
Pages
323-336
ISSN
  • 0001-690X (ISSN-L)
  • 1600-0447
DOI
10.1111/j.1600-0447.2008.01163.x
OpenAlex
W1965388866
Cited by
209
References
63
Citations by year
2026: 2 · 2025: 7 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 11 · 2020: 11 · 2019: 8 · 2018: 15 · 2017: 14 · 2016: 12 · 2015: 12 · 2014: 18 · 2013: 15 · 2012: 13
FWCI
2.19
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Acta Psychiatrica Scandinavica (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Health Sciences › Medicine › Oncology › Global Cancer Incidence and Screening
Keywords
schizophrenia, cancer incidence, lung cancer, breast cancer, first-degree relatives, siblings, parents, smoking, standardized incidence ratio, cancer risk
MeSH terms
Aged, Urinary Bladder Neoplasms, Humans, Lung Neoplasms, Neoplasms, Risk Factors, Schizophrenia, Incidence, Prevalence

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